A primary care cross-sectional study of undiagnosed adult coeliac disease

Sanders, David S.; Patel, Dina; Stephenson, T.J.; Ward, A. Milford; McCloskey, Eugène; Hadjivassiliou, Marios; Lobo, Alan

doi:10.1097/00042737-200304000-00012

Cited by 230 publications

(165 citation statements)

References 29 publications

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“…[1][2][3] However, despite increased awareness, celiac disease remains under-diagnosed. A recent UK study demonstrated that only 1 in 4 patients with celiac disease are currently diagnosed.…”

Section: Introductionmentioning

confidence: 99%

Clinical and Immunologic Features of Ultra-Short Celiac Disease

et al. 2016

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Section: Introductionmentioning

confidence: 99%

Clinical and Immunologic Features of Ultra-Short Celiac Disease

et al. 2016

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“…In the United Kingdom in 1950 the incidence of CD was reported as 1 in 8,000 ( 32 ). However, we and others including US investigators have reported in the last decade that CD aff ects up to 1 % of all adults ( 5,10 ).…”

Section: What Effect Has Gluten or Wheat Had On Mankind?mentioning

confidence: 70%

“…What is intriguing is that within this study Cash et al ( 23 )found that in their cohort of IBS patients, despite only 0.41 % being found to have CD, just over 7 % had CD-associated antibodies, predominantly IgG antigliadin antibodies (AGA) (4.88 % ) and IgA AGA (1.63 % ). Our group has previously reported that AGA were present in ~ 12 % of the general population and ~ 17 % in IBS (both in the presence of a normal small bowel biopsy) ( 10,14 ). Furthermore, Kaukinen et al ( 24 ) noted that the majority of patients with cereal induced (to gluten) on small bowel aspirate to defi ne an IBS subgroup ( n = 26).…”

Section: What Is the Relationship Between Ibs And Celiac Disease?mentioning

confidence: 90%

Editorial: Non-Celiac Wheat Sensitivity: Separating the Wheat from the Chat!

Sanders

Aziz

2012

American Journal of Gastroenterology

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Historically, it has been reported that patients with undetected celiac disease (CD) may present with irritable bowel syndrome (IBS) type symptoms. This has led to the recommendation by the American College of Gastroenterology Task force that patients presenting with diarrhea predominant IBS type symptoms should be serologically tested for CD. Concurrently speculative media data suggest that the US general public have increased their uptake of a gluten-free diet (GFD) far in excess of the known prevalence of CD. This may suggest that individuals with gastrointestinal symptoms are deriving benefi t from a GFD even if they do not have CD. This has led to the scientifi c community considering the evidence for an emerging concept of non-celiac wheat sensitivity. There is a signifi cant disparity in our views about what this phenomenon may be. There is also confusion about the nomenclature for this entity and indeed whether patients are suffering due to symptoms related to gluten or perhaps other components of wheat, for example fructans. In this month ' s edition of the American Journal of Gastroenterology , we see evidence to support the clinical concept of wheat sensitivity or intolerance. Irrespective of the nomenclature Carroccio provides a clinically applicable approach that may be adopted internationally by clinicians. This offers a new option in our armamentarium when seeing patients with IBS type symptoms.

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“…The etiology is not known, but environmental, immunological and genetic factors are held responsible for the condition. Celiac disease has been estimated to occur in up to 1% of the general population, and although was traditionally considered a childhood disease it may appear at any age, including the elderly (1)(2)(3)(4). Clinical presentations of the disease are highly variable.…”

mentioning

confidence: 99%

“…Though diarrhea and weight loss are usually present, in some patients manifestations of the disease may be protean. Moreover, some cases may present with only extra-intestinal symptoms without any obvious gastrointestinal changes (1,2). Neurological disorders, including peripheral neuropathy, ataxia, seizures and cognitive dysfunction have been reported in patients suffering from celiac disease; in some these disorders may be the initial manifestation of the disease, leading to its recognition (3-7).…”

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confidence: 99%

Celiac Disease Presenting with Motor Weakness

Demirci¹,

Cengizhan²,

Karahan³

2012

J Turgut Ozal Med Cent

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Many systemic diseases may present with neurological signs and symptoms. In this case report, it is aimed to emphasize some takehome lessons in regard with disease that may masquerade Guillain-Barre syndrome. A 23 years-old woman presented with acute ascending motor weakness and areflexia for which she was presumed to have a Guillain-Barre syndrome. On neurological examination she had a muscle power of 2/5 according to MRC with areflexia. She had severe hypokalemia which is thought to result from the diarrhea she had. With potassium replacement her motor power resolved to normal. Detailed differential work-up led to a diagnosis of celiac disease with positive anti-gliadin antibodies serology and duodenal biopsy. Differential of acute, bilateral muscle weakness requires consideration of a few neurological conditions. However, the physicians should be aware of that many other systemic diseases may also manifest with signs and symptoms mimicking these neurological conditions.

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A primary care cross-sectional study of undiagnosed adult coeliac disease

Cited by 230 publications

References 29 publications

Clinical and Immunologic Features of Ultra-Short Celiac Disease

Clinical and Immunologic Features of Ultra-Short Celiac Disease

Editorial: Non-Celiac Wheat Sensitivity: Separating the Wheat from the Chat!

Celiac Disease Presenting with Motor Weakness

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