A previously undetected pathology of Zika virus infection

Christian, Kimberly M.; Song, Hongjun; Ming, Guo Li

doi:10.1038/nm.4510

Cited by 2 publications

(3 citation statements)

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“…A recent epidemic with similar consequences is Zika virus infection, which causes microcephaly with cognitive disability. The Zika virus impairs Musashi-1 function in neural progenitors, leading to decreased neurogenesis in both the cortex and the dentate gyrus and therefore an overall decrease in size ( Chavali et al, 2017 ; Christian et al, 2018 ). Moreover, the Zika virus disorganizes the granule cell layer and strata, in addition to predisposes infants to brain calcifications ( Christian et al, 2018 ).…”

Section: Main Textmentioning

confidence: 99%

“…Accompanying these structural deficits to the brain are insults to neural circuit development. The Zika virus promotes gliosis, impairs myelination, disrupts synaptogenesis, and alters the levels of SHH and FGF ( Christian et al, 2018 ; Thawani et al, 2018 ). But, during normal development it should be noted that even before secreted molecules such as SHH, FGF, and REELIN impact cell placement, lineage history and birthdate initiate a spatial and temporal order of cellular invasion of a territory ( Sudarov et al, 2011 ).…”

Section: Main Textmentioning

confidence: 99%

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Shaping Diversity Into the Brain’s Form and Function

Miterko

Lackey

Heck

et al. 2018

Front. Neural Circuits

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The brain contains a large diversity of unique cell types that use specific genetic programs to control development and instruct the intricate wiring of sensory, motor, and cognitive brain regions. In addition to their cellular diversity and specialized connectivity maps, each region’s dedicated function is also expressed in their characteristic gross external morphologies. The folds on the surface of the cerebral cortex and cerebellum are classic examples. But, to what extent does structure relate to function and at what spatial scale? We discuss the mechanisms that sculpt functional brain maps and external morphologies. We also contrast the cryptic structural defects in conditions such as autism spectrum disorders to the overt microcephaly after Zika infections, taking into consideration that both diseases disrupt proper cognitive development. The data indicate that dynamic processes shape all brain areas to fit into jigsaw-like patterns. The patterns in each region reflect circuit connectivity, which ultimately supports local signal processing and accomplishes multi-areal integration of information processing to optimize brain functions.

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Section: Main Textmentioning

confidence: 99%

Section: Main Textmentioning

confidence: 99%

Shaping Diversity Into the Brain’s Form and Function

Miterko

Lackey

Heck

et al. 2018

Front. Neural Circuits

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“…In recent years, advances in multiparameter flow cytometry, high-throughput technologies, and robust imaging techniques have produced an abundance of quantitative data and illuminated the need for new theoretical approaches that can unravel complex biological interactions. In addition, the emergence of new data on multi-pathogen infections (reviewed in [9]), important viral-induced pathologies (e.g., by Zika virus (ZV) [10,11], Ebola virus (EV) [12], or BK virus (BKV) [13]) and better data on virus-induced autoimmunity (e.g., by EBV [4]) has opened the door for novel investigative designs. For over 20 years, mathematical models have been developed to assess infection kinetics during acute or chronic viral infection to better understand virus replication, elucidate mechanisms of viral persistence and control by host immune responses, disentangle pathogen-pathogen interplay, and evaluate the clinical potential of different antiviral therapies [cite].…”

Section: Introductionmentioning

confidence: 99%

Validated models of immune response to virus infection

Smith

2018

Current Opinion in Systems Biology

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Viruses are a main cause of disease worldwide and many are without effective therapeutics or vaccines. A lack of understanding about how host responses work to control viral spread is one factor limiting effective management. How different immune components regulate infection dynamics is beginning to be better understood with the help of mathematical models. These models have been key in discriminating between hypotheses and in identifying rates of virus growth and clearance, dynamical control by different host factors and antivirals, and synergistic interactions during multi-pathogen infections. A recent focus in evaluating model predictions in the laboratory and clinic has illuminate the accuracy of models for a variety of viruses and highlighted the critical nature of theoretical approaches in virology. Here, I discuss recent model-driven exploration of host-pathogen interactions that have illustrated the importance of model validation in establishing the model’s predictive capability and in defining new biology.

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A previously undetected pathology of Zika virus infection

Abstract: In a nonhuman primate model of Zika virus infection, structural and cellular pathology deficits that could have a long-lasting impact on neural development and neurocognitive function are detected in offspring of infected mothers.

Cited by 2 publications

References 12 publications

Shaping Diversity Into the Brain’s Form and Function

Shaping Diversity Into the Brain’s Form and Function

Validated models of immune response to virus infection

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