“…Twelve studies used a non-concurrent cohort study design. 16,19,[21][22][23]26,27,29,31,34,40,41 A before-andafter design was used in 4 studies, 32,38,42,43 and a crosssectional design was used in 3 studies, 25,28,37 as well as a controlled before-and-after study, 24 a non-comparative design, 39 and a retrospective cohort study. 18 Given the focus of this study on cost savings, it was not surprising that the most frequently studied topic related to mechanical ventilation management/liberation protocols.…”