A prevalência da Esofagite Eosinofílica no Brasil – uma revisão de literatura

Queirós, M.C.; Bandeira, Lucas Alves; Souza, Ana Elisa de Freitas; Paiva, Samuel Rezende; Alcántara, Valeria; Mouro, Maria Fernanda; Santos, Ignacio J. Amat; Alves, H.; Marinheiro, Nicolle Pires Bastos; Perissê, Rafaella Afonso Tormin

doi:10.34117/bjdv9n5-157

Cited by 2 publications

(1 citation statement)

References 11 publications

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“…Currently, the prevalence of the disease has been increasing worldwide ( 2 , 3 ). In Brazil, this number varies from 10 to 50/100.000 people, based on adult and pediatric population ( 4 ). The incidence is constantly rising and is estimated to be 10/100.000 cases per year in the country ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

High prevalence of response to PPI treatment in children and adolescents with eosinophilic esophagitis in southern Brazil

Nader,

Epifanio,

Coelho

et al. 2024

Front. Allergy

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IntroductionEosinophilic esophagitis is a newly recognized entity, in which there is significant evidence available that clearly demonstrates the positive impact of PPIs on reducing esophageal eosinophilia in individuals across different age groups, including children, adolescents, and adults. Multiple mechanisms have been proposed to explain how this treatment effect occurs. In Brazil, there seems to be a lack of studies that have prospectively assessed the clinical and therapeutic response rate in pediatric patients with EoE. The objective of this study was to prospectively evaluate the clinical and therapeutic response of pediatric patients with EoE in a medical center located in southern Brazil, by investigating the effectiveness of PPI treatment.MethodsThis study is a clinical, prospective, open trial that took place in a pediatric hospital located in southern Brazil. The focus of the study was on patients diagnosed with Eosinophilic Esophagitis (EoE) who were given treatment using omeprazole/esomeprazole at a dosage of 1 mg.kg per dose, twice daily, for a period of 8–12 weeks. Following the treatment period, the patients underwent another endoscopy. Patients who exhibited 15 or less eosinophils in the biopsy conducted after the treatment were considered as responders.ResultsA total of 27 patients was evaluated (74.1% boys). The average age (± standard deviation) was 8 years (±4). Nineteen patients (70.3%) were considered as responders to PPI treatment: 6 patients—22.2%—exhibited a complete response (defined as having 5 or fewer eosinophil per high power field. Additionally, 13 patients—48.1%—demonstrated a partial response, characterized by eosinophil counts exceeding 5 but less than 15 eos/hpf. When comparing the responder and non-responder groups at presentation, a statistical difference was observed in the prevalence of food refusal as a presenting symptom. Food refusal was found to be more prevalent in the non-responder group (87.5% vs. 26.3%, P = 0.008). No differences were observed in terms of atopy history and endoscopic scores. Upon comparing the histological findings from the post-treatment endoscopy of the two groups, it was observed that PPI responders exhibited a greater tendency to decrease basal cell hyperplasia (P = 0.06) and intercellular edema (P = 0.08).ConclusionIn this group of pediatric patients with EoE in Southern Brazil most patients showed a high prevalence of histological, endoscopic, and clinical response to PPI treatment. PPIs showed efficacy in Brazilian patients with EoE, most of whom would probably not be able to adequately undergo other treatments. Clinical Trial Registrationhttps://ensaiosclinicos.gov.br/rg/RBR-2ntbth9, identifier (U1111-1301-1842).

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Section: Introductionmentioning

confidence: 99%

High prevalence of response to PPI treatment in children and adolescents with eosinophilic esophagitis in southern Brazil

Nader,

Epifanio,

Coelho

et al. 2024

Front. Allergy

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The Interrelation Between Esophagitis and Hydrogen Sulfide: A Literature Review

Melo,

Barroso,

Sousa

et al. 2024

Rev. Foco

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Esophagitis is characterized by irritation and inflammation of the esophagus, caused by several factors, such as gastroesophageal reflux, radiation, infections, medications and eosinophilic esophagitis. Its symptoms include chest pain, odynophagia, dysphagia, nausea, vomiting, throat clearing, heartburn, dry cough and manifestations related to gastroesophageal reflux. And its pathophysiology involves lesions in the esophageal mucosa due to the abnormal and frequent increase in gastric acid. With regard to hydrogen sulfide (H2S), it is a toxic gaseous compound with an odor similar to rotten eggs, it performs essential physiological functions, stabilizing mucus, preventing injuries and strengthening gastrointestinal defense mechanisms by stimulating the secretion of bicarbonate in the duodenum. . The purpose of this article is to analyze the relationship between hydrogen sulfide and esophagitis. Therefore, this integrative review covered original articles in Portuguese and English, published from 2003 to 2022, in the VHL, SciELO and PUBMED databases. Using descriptors such as “esophagitis,” “gastrointestinal,” and “hydrogen sulfide,” the research followed strict inclusion criteria to provide a comprehensive analysis of the relationship between esophagitis, gastrointestinal health, and hydrogen sulfide. As for the results and discussions, they highlight the relationship between H2S and esophagitis, exploring its antioxidant and anti-inflammatory function by protecting cells from oxidative stress by increasing glutathione (GSH) and contributing to quenching reactive oxygen species and promoting the resolution of inflammation. mainly how it interferes with the production of pro-inflammatory cytokines, such as IL-1, IL-2, IL-8 and TNFα, in addition to maintaining or increasing the production of IL-10. Through the results obtained, it can be concluded that esophagitis has an intimate relationship with the modulation of hydrogen sulfide levels in the human body, particularly in the context of the H2S/CSE/HIF-2α axis and that they should be better studied in order to promote the development of H2S-based drugs to treat inflammatory processes, including esophagitis, which have the potential to significantly improve the well-being and quality of life of the population.

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A prevalência da Esofagite Eosinofílica no Brasil – uma revisão de literatura

Cited by 2 publications

References 11 publications

High prevalence of response to PPI treatment in children and adolescents with eosinophilic esophagitis in southern Brazil

High prevalence of response to PPI treatment in children and adolescents with eosinophilic esophagitis in southern Brazil

The Interrelation Between Esophagitis and Hydrogen Sulfide: A Literature Review

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