A prevalence study of primary dystonia in eight European countries

Warner, Thomas T.; Camfield, Laura; Marsden, C. D.; Németh, Andrea H.; Hyman, N; Harley, Dave; Wissel, Jörg; Poewe, Werner; Marttila, Reijo J.; Erjanti, Hanna; Burbaud, Pierre; Lagueny, A; Kamm, Christoph; Gasser, Thomas; Franz, Peter; Castelon-Konkiewitz, E.; Trender, I.; Ceballos-Baumann, Andrés; Nebe, Angelika; Fruedenberg, B.; Bentivoglio, Anna Rita; Cassetta, Emanuele; Albanese, Alessio; Currà, Antonio; Vacca, Laura; Berardelli, Alfredo; Ferreira, Joaquim J.; Sampaio, Cristina; Passao, V.; Marti, Fritz; Tolosa, Eduard; Clavería, L. E.; Duarte, Juliana Ávila; Ben-Shlomo, Yoav; Newton, A.

doi:10.1007/s004150070094

Cited by 315 publications

(99 citation statements)

References 15 publications

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“…Jedynak et al [6], in their prospective study of 65 patients of WC in European population also reported that the mean age of onset of WC was 36.3 ± 12. The Epidemiological Study of Dystonia in Europe (ESDE) Collaborative Group in their prevalence study of dystonia in Europe, reported WC to be more prominent in the 50-59 years age group [8]. However, this report did not mention the duration of WC in this population, which precludes any information on the age of onset of WC.…”

Section: Discussionmentioning

confidence: 56%

“…Demographic and clinical characteristics of WC have been previously reported either by studies exclusively reporting on WC [5,6] or by studies highlighting the characteristics of the focal task-specific hand dystonias where some patients had WC [7,8] (table 2). In this study on Indian population, we report the clinical characteristics of a large cohort of patients with WC.…”

Section: Discussionmentioning

confidence: 99%

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A Clinical Profile of 125 Patients with Writer's Cramp

Jhunjhunwala

Lenka

Pal³

2015

Eur Neurol

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Background: The characteristics of writer's cramp (WC) may vary according to native languages and scripts. We report the clinical profile of a large cohort of patients with WC from India. Methods: A chart review of 125 patients (F:M = 16:109) with WC seen over 10 years at the National Institute of Mental Health and Neurosciences (NIMHANS), India. Results: The mean age of patients was 36.8 ± 14.3, the mean age at onset (AAO) of symptoms was 31.5 ± 2.7 and the mean duration of difficulty in writing was 5.3 ± 6.3. The most common presenting complaint while writing was pain in the forearm (56%), followed by tremulousness of hand (28.8%) and abnormal posturing of hand (15.2%). Along with writing difficulty, 5.6% had difficulty in typing. The mean AAO of writing difficulty was significantly earlier in women than in men (22.8 ± 3.5 vs. 32.8 ± 4.2 years, p < 0.001). While writing, excessive extension (41.6%) of wrist was the most common abnormality, followed by excessive flexion (37.6%) and extension (19.2%) of index finger. Conclusions: Women with WC have a significantly earlier age of onset than men. Excessive extension of wrist with flexion of thumb and index finger were the most common abnormalities noted in WC.

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Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 99%

A Clinical Profile of 125 Patients with Writer's Cramp

Jhunjhunwala

Lenka

Pal³

2015

Eur Neurol

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“…The prevalence of CD in the general population is estimated to vary from 0.006% from a clinic-based study in eight European countries to 0.4% in the US", based on a consumer database survey [3,4].…”

Section: Introductionmentioning

confidence: 99%

“…CD remains the most common of the focal dystonias [3,5]. Classiications of CD include torticollis (turning or rotation of the head towards one side); laterocollis (tilting of the head towards one side); anterocollis (head and neck lexion); and retrocollis (head and neck extension) or a combination of these movements [1,2].…”

Section: Introductionmentioning

confidence: 99%

How Effective and Safe is Botulinum Toxin Therapy in Cervical Dystonia: The Current Stand

Jamora¹,

Piano²

2016

Botulinum Toxin Therapy Manual for Dystonia and Spasticity

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Cervical dystonia (CD) is the most common focal dystonia that is characterized by involuntary contraction of cervical muscles causing abnormal head movements and postures. The treatment for CD was previously limited to oral medications, however, with consequent systemic side efects. In recent years, botulinum toxin ("oNT) has demonstrated eicacy in several studies and thus has received level " recommendation from both the "merican "cademy of Neurology and the European Federation of Neurological Sciences in the treatment of dystonia. In many countries, it is the irst-line treatment for CD. There are four types of toxin approved for the use in CD, three type " [Onabotulinumtoxin" (Ona"oNT"), "bobotulinumtoxin" ("bo"oNT"), and Incobotulinumtoxin " (Inco"oNT")] and one type " [Rimabotulinumtoxin" (Rima-"oNT")]. Proper selection of afected muscles and dose of toxin are important parameters in successfully providing symptomatic treatment. Good response rate is deined as improvement of more than 25 % from baseline using the Toronto Western Torticollis Rating Scale. The most common side efect of chemodenervation with "oNT for CD is dysphagia.

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“…27 Outside of the United States, the prevalence of individuals with pri-mary focal dystonia who presented to outpatient clinics ranges between 61 and 137 per million persons. 9,11,16,26,31 Whereas primary focal dystonia is relatively rare, task-specific lower extremity dystonia is even less prevalent. Within a specialized movement-disorder clinic, only 4 (0.7%) of 579 individuals with primary focal dystonia had lower extremity dystonia, 21 and none of these individuals presented with the specific movement pattern described in this case.…”

mentioning

confidence: 99%