A presença de fármacos e cafeína em água superficial e destinada ao consumo humano

Carvalho, Ana Carla Coleone de

doi:10.11606/t.6.2021.tde-27012021-150527

Cited by 1 publication

(1 citation statement)

References 113 publications

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“…The water used in the experimental aquaria came from the public water treatment company of the State of São Paulo, Brazil (SABESP; Companhia de Saneamento Básico do Estado de São Paulo), which provides high quality water to the population. The presence of FLX is considered very rare in untreated water here and absent in treated water [51]. Nevertheless, the water used for our experiments was initially treated with sodium hypochlorite to remove any existing organic molecules, including any potential traces of FLX [52].…”

Section: Experimental Aquariamentioning

confidence: 99%

Acute Effects of Fluoxetine on Stress Responses and Feeding Motivation in Nile Tilapia

Miranda

Isaac

Silva

et al. 2023

Fishes

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The selective serotonin reuptake inhibitor fluoxetine is one of the most commonly administered psychotropic medications; however, it has been recognized as toxic to aquatic life. In this study, we showed that stress responses and feeding motivation in Nile tilapia were affected by acute exposure to fluoxetine. To reach that conclusion, we exposed Nile tilapia to 0, 1 or 10 µg/L (environmentally/biologically relevant doses) of fluoxetine over a 24 h period and then exposed them to a handling stressor. We found that the 10 µg/L dose enhanced cortisol response to stress but caused an earlier decrease in the ventilation boost induced by that stressor. An immediate ventilation boost after stressful stimuli indicates sympathetic activation. Thus, this suggests that fluoxetine decreased sympathetic nervous system activity but augmented hypothalamus–pituitary–interrenal axis activity in the fish. Both feeding latency and ingestion were similar among the tested conditions; however, a multiple logistic regression model revealed that in the presence of a stressor or fluoxetine, the Nile tilapia tended to ingest less food but there was a higher probability of this decrease to be associated with fluoxetine. We concluded that acute exposure to environmentally/biologically relevant fluoxetine concentrations over 24 h acted as a modifying factor for Nile tilapia stress physiology and tended to interfere with feeding motivation. An acute stress response is an emergency reaction that contributes to the recovery of homeostasis. In the presence of fluoxetine, modifications of acute stress responses and the tendency to reduce food intake, which restricts the ability to replace the energy spent on stress responses, could compromise the resumption of homeostasis and an animal’s adjustment to different environmental contexts, such as those associated with aquaculture, in which anthropogenic stressors inevitably occur.

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Section: Experimental Aquariamentioning

confidence: 99%