A prenatal prediction model for total nucleated cell count increases the efficacy of umbilical cord blood banking

Manegold-Brauer, Gwendolin; Borner, Barbara; Bucher, Christoph; Hoesli, Irène; Passweg, Jakob; Girsberger, Sabine; Schoetzau, Andreas; Gisin, Stefan; Visca, E.

doi:10.1111/trf.12676

Cited by 11 publications

(32 citation statements)

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“…In India, the present study is the first to characterize both CD34+ and CD90+ cell content in cord blood with respect to some of the major neonatal parameters. Significant impact of birth weight on HSC content of the cord blood has been reported by other studies [15][16][17], which is found to be supportive to the present observation. Results of multivariable analysis showed that with the unit rise in birth weight there was an increment of 0.761% of CD34+ and 0.799% of CD90+ cell counts.…”

Section: Discussionsupporting

confidence: 95%

Association of CD34+ and CD90+ Stem Cells of Cord Blood with Neonatal Factors: A Cross-sectional Study

et al. 2015

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Section: Discussionsupporting

confidence: 95%

Association of CD34+ and CD90+ Stem Cells of Cord Blood with Neonatal Factors: A Cross-sectional Study

et al. 2015

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“…Por otro lado, se encontró, que de las variables neonatales, la longitud del cordón fue la única que se correlacionó con el recuento total de células nucleadas y no hubo ninguna otra correlación entre las demás variables maternas o neonatales analizadas como vía del parto, peso materno, edad gestacional, peso de placenta, peso del bebé datos que contrastan en cuanto a que el peso del neonato al momento del nacimiento es el principal factor neonatal que afecta el Numero de CD34+ y Recuento de células nucleadas (7)(8)(9)(10)22,(26)(27)(28)(29)(30)(31). Llama la atención el hecho que se hubiera encontrado correlación solamente entre la longitud del cordón umbilical y el recuento total de células nucleadas y no también con el recuento de células CD34+, teniendo en cuenta, y según los resultados del presente estudio, la existencia de correlación entre estos dos marcadores de calidad, inquietudes que valen la pena tener en cuenta para próximas investigaciones.…”

Section: Discussionunclassified

Correlación entre características físicas neonatales y maternas con el recuento total de células nucleadas y de células CD34+ por microlitro en sangre de cordón umbilical

et al. 2015

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ResumenIntroducción: La sangre de cordón umbilical (SCU) ha sido reconocida como una fuente de células madre hematopoyéticas. Múltiples estudios han sido realizados con el propósito de determinar variables maternas y neonatales que afecten el volumen, el recuento total de células nucleadas y de células CD34+. El presente estudio correlaciona variables maternas y neonatales con el recuento total de células nucleadas y de CD34+ medidas en µL (microlitro). Materiales y Métodos:Estudio correlacional en el que se analizaron 50 muestras de sangre de cordón umbilical de gestantes atendidas en dos IPS, una de Bogotá y otra de Ubaté, (Cundinamarca), durante un período de 7 meses del año 2013. La selección de estas muestras fue basada en un muestreo no probabilístico. Se calculó el coeficiente de correlación de Pearson con su respectiva significancia estadística entre las variables cuantitativas de la madre y del neonato, y el volumen, el recuento de células CD34+ y el recuento total de células nucleadas por µL. Resultados:Se encontró correlación positiva entre la longitud del cordón y el recuento total de células nucleadas. Así mismo entre el volumen inicial de la muestra y el recuento total de células nucleadas y el recuento de células CD34+ en µL y en mL (mililitro). Discusión:Múltiples estudios se han desarrollado entorno a la búsqueda de variables maternas y neonatales que afectan la calidad de la muestra. En Colombia no se habían descrito las correlaciones encontradas en el presente estudio. Es por ello, que el desarrollo de nuevos estudios con diseños analíticos será enriquecedor. Palabras claves: Células madre, antígeno CD34+, trasplante de células madre de sangre de cordón umbilical (SCU), neonatal, materno, factores de riesgo. CORRELATION BETWEEN NEONATAL AND MATERNAL PHYSICAL CHARACTERISTICS WITH TOTAL NUCLEATED CELL COUNT AND CELL COUNT PER MICROLITER CD34+ IN CORD BLOOD AbstractBackground: The cord blood has been recognized as a source of hematopoietic stem. Multiple studies have been conducted in order to determine maternal and neonatal variables that affect the volume, total nucleated cell count and CD34+ cells. This study correlated maternal and neonatal variables with the total nucleated cell count and CD34+ cells measured by µL. Materials and methods: Correlational study in which 50 samples of umbilical cord blood were analyzed of pregnant women at two health institutions, one at Bogotá and the other one at Ubaté, Cundinamarca, for a period of seven months of 2013. The selection of these samples was based on a non-probability sample. The Pearson correlation coefficient was calculated with their respective statistical significance between quantitative variables of mother and newborn, and the volume, the count of CD34+ cells and the total nucleated cell count measured by µL. Results:Positive correlation between the length of the umbilical cord and the total nucleated cell count was found. Similarly, correlation between total nucleated cell count with the initial volume and count of CD34+ cells in µL and m...

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“…At different gestational ages, the volumes of UCBs obtained and the proportions of UCB‐SCs are different. Higher gestational ages are related to larger volumes of UCB and greater total nucleated cell (TNC) counts, whereas lower gestational ages are associated with greater numbers of hematopoietic stem cells and greater numbers of colony‐forming units (CFUs) of UCBCs (Manegoldbrauer et al, ). In preterm UCB, there are fewer nucleated cell counts, probably due in part to decreased placental weight and size.…”

Section: Sources Of Ucb‐scs In Preterm Infantsmentioning

confidence: 99%

“…The quality and quantity of UCB‐SCs can be influenced by many kinds of perinatal factors. Studies have shown that maternal body mass index is positively correlated with TNC counts (Alsweedan, Musalam, & Obeidat, ; Manegoldbrauer et al, ). However, parity is negatively correlated with CFUs and TNC counts (Manegoldbrauer et al, ), and there is a 17% decrease in hematopoietic stem cell counts with every additional birth (Ballen et al, ).…”

Section: Sources Of Ucb‐scs In Preterm Infantsmentioning

confidence: 99%

“…Studies have shown that maternal body mass index is positively correlated with TNC counts (Alsweedan, Musalam, & Obeidat, ; Manegoldbrauer et al, ). However, parity is negatively correlated with CFUs and TNC counts (Manegoldbrauer et al, ), and there is a 17% decrease in hematopoietic stem cell counts with every additional birth (Ballen et al, ). Maternal age is also related to UCB‐SC counts; for example, mothers aged 20 years or older have greater proportions of CFUs, TNCs, and hematopoietic stem cells than mothers younger than 20 years of age (Page et al, ).…”

Section: Sources Of Ucb‐scs In Preterm Infantsmentioning

confidence: 99%

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Umbilical cord blood stem cell therapy in premature brain injury: Opportunities and challenges

Peng

Shi

et al. 2019

J of Neuroscience Research

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Preterm birth and associated brain injury are the primary cause of cerebral palsy and developmental disabilities and are among the most serious global health issues that modern society faces. Current therapy for infants suffering from premature brain injury is still mainly supportive, and there are no effective treatments. Thus there is a pressing need for comparative and translational studies on how to reduce brain injury and to increase regeneration and brain repair in preterm infants. There is strong supporting evidence for the use of umbilical cord blood (UCB)‐derived stem cell therapy for treating preterm brain injury and neurological sequelae. UCB‐derived stem cell therapy is effective in many animal models and has been shown to be feasible in clinical trials. Most of these therapies are still experimental, however. In this review, we focus on recent advances on the efficacy of UCB‐derived stem cell therapy in preterm infants with brain injury, and discuss the potential mechanisms behind their therapeutic effects as well as application strategies for future preclinical and clinical trials.

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A prenatal prediction model for total nucleated cell count increases the efficacy of umbilical cord blood banking

Abstract: Our prenatal prediction model increases the efficacy of obtaining informed consent for UCB banking while still allowing relevant numbers of CBUs to be banked.

Cited by 11 publications

References 25 publications

Association of CD34+ and CD90+ Stem Cells of Cord Blood with Neonatal Factors: A Cross-sectional Study

Association of CD34+ and CD90+ Stem Cells of Cord Blood with Neonatal Factors: A Cross-sectional Study

Correlación entre características físicas neonatales y maternas con el recuento total de células nucleadas y de células CD34+ por microlitro en sangre de cordón umbilical

Umbilical cord blood stem cell therapy in premature brain injury: Opportunities and challenges

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