volume 32, issue 1, P101-107 2012
DOI: 10.3233/jad-2012-111508
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Abstract: We have shown that experience of transgenic mice harboring familial Alzheimer’s disease (FAD)-linked AβPPswe/PS1ΔE9 in an enriched environment enhances hippocampal neurogenesis and synaptic plasticity and attenuates neuropathology. Nevertheless, the neuronal pathways activated following environmental enrichment underlying this effect are unknown. Using resting-state functional magnetic resonance imaging, we present preliminary evidence to show that transgenic mice, which had been housed in an enriched environ…

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