A preliminary study on using reverberant shear wave fields in optical coherence elastography to examine mice brain ex vivo

Ge, Gary R.; Zvietcovich, Fernando; Rolland, Jannick P.; Mestre, Humberto; Giannetto, Michael; Parker, Kevin J.

doi:10.1117/12.2516039

Cited by 4 publications

(4 citation statements)

References 30 publications

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“…The application of wave-based OCE has also been instrumental in the study of other ex vivo tissues, including skin elastography using air-pulse [103] and laser-based [113] stimulation; the study of cardiac tissues under normal conditions [104] and myocardial infarction [105,106], heart valves [189], uterus [190], liver [52,123], brain [76,191], cartilage [107], soft tumors [93], skeletal muscle [61], diaphragm muscle [24], and breast [192] tissues. Besides the study of ocular tissues, skin elastography has been of major interest in wave-based OCE since the imaging resolution of OCT implementations is capable of resolving tissue layers such as epidermis, dermis, and hypodermis with great detail compared to other imaging modalities.…”

Section: Other Tissuesmentioning

confidence: 99%

Wave-based optical coherence elastography: the 10-year perspective

Zvietcovich

Larin

2022

Prog. Biomed. Eng.

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After ten years of progress and innovation, optical coherence elastography (OCE) based on the propagation of mechanical waves has become one of the major and, perhaps, one of the most studied OCE branches, producing a fundamental impact in the quantitative and nondestructive biomechanical characterization of tissues. Preceding previous progress made in ultrasound and magnetic resonance elastography; wave-based OCE has pushed to the limit the advance of three major pillars: (1) implementation of novel wave excitation methods in tissues, (2) understanding new types of mechanical waves in complex boundary conditions by proposing advance analytical and numerical models, and (3) the development of novel estimators capable of retrieving quantitative 2D/3D biomechanical information of tissues. This remarkable progress promoted a major advance in answering basic science questions and improving medical disease diagnosis and treatment monitoring in several types of tissues leading, ultimately, to the first attempts of clinical trials and translational research. This paper summarizes the fundamental up-to-date principles and categories of wave-based OCE, revises the timeline and the state-of-the-art techniques and applications lying in those categories, and concludes with a discussion of current challenges and future directions, including clinical translation research.

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Section: Other Tissuesmentioning

confidence: 99%

Wave-based optical coherence elastography: the 10-year perspective

Zvietcovich

Larin

2022

Prog. Biomed. Eng.

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“…Several applications have been reported using OCE, including non-contact mechanical stimulation (Huang et al 2009, Ambrozinski et al 2016. The main applications are found in cornea (Ford et (Guan et al 2013), and ex vivo mouse brain (Ge et al 2019). Figure 16 shows the application of OCE in ex vivo porcine cornea using the reverberant SWE approach (Zvietcovich et al 2019b).…”

Section: Optical Elastographymentioning

confidence: 99%

Elastography imaging: the 30 year perspective

Ormachea

Parker

2020

Phys. Med. Biol.

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From the development of x-ray imaging in the late 19th century, the field of medical imaging developed an impressive array of modalities. These can measure and image a variety of physical parameters from absorption coefficients to spin–spin relaxations. However, throughout most of the 20th century, the intrinsic biomechanical properties of tissues remained hidden from conventional radiology. This changed around 1990 when it was demonstrated that medical ultrasound systems with their fast pulse repetition rate and high sensitivity to motion could create images related to the stiffness of tissues and their shear wave properties. From there, vigorous development efforts towards imaging the elastic properties of tissues were launched across different modalities. These progressed from the research phase, through implementation on clinical scanners, through extensive clinical trials of selected diagnostic tasks, to government approvals, payer approvals, international standards statements, and into routine clinical practice around the globe. This review covers highlights of some major topics of the technical and clinical developments over the last 30 years with brief pointers to some of the remaining issues for the next decade of development.

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“…Several posters were devoted to further refinement of OCE and exploring its new applications. For example, Dr. Kevin Parker's group at the University of Rochester 44 presented their preliminary studies of reverberant shear wave fields to characterize brain tissue elasticity of mice in OCE. Those experiments were performed on mice brains ex vivo with a portion of the skull replaced by glass windows to allow for optical imaging and demonstrated promising potential of OCE for quantitative brain imaging.…”

Section: Poster Sessionmentioning

confidence: 99%

Optical elastography and tissue biomechanics

2019

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Mechanical forces play an important role in the behavior and development of biological systems and disease at all spatial scales, from cells and their constituents to tissues and organs. Such forces have a profound influence on the health, structural integrity, and normal function of cells and organs. Accurate knowledge of cell and tissue biomechanical properties is essential to map the distribution of forces and mechanical cues in biological systems. Cell and tissue biomechanical properties are also known to be important on their own as indicators of health or disease states. Hence, optical elastography and biomechanics methods can aid in the understanding and clinical diagnosis of a wide variety of diseases. We provide a brief overview and highlight of the Optical Elastography and Tissue Biomechanics VI conference, which took place in San Francisco, February 2 and 3, 2019, as a part of Photonics West symposium.

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A preliminary study on using reverberant shear wave fields in optical coherence elastography to examine mice brain ex vivo

Cited by 4 publications

References 30 publications

Wave-based optical coherence elastography: the 10-year perspective

Wave-based optical coherence elastography: the 10-year perspective

Elastography imaging: the 30 year perspective

Optical elastography and tissue biomechanics

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