A Preliminary Study on the Use of Ultrasound for Obtaining Pulsatile Release

Abstract

Plasma concentrations of drug depend on the frequency of administration. In conventional drug release, the blood concentration of the drug increases, reaches a peak and falls after the drug administration. For these reasons, we plan to work responsive systems in our study. We have examined the response of different drug content of the polymeric tablets to the ultrasound. Polymeric controlled drug delivery systems were used to obtain controlled drug delivery. In this study, the relationship between the release rate constants, ultrasound and drug contents were investigated. It is found that the ultrasound has a very important effect on the release of drug and increases drug release clearly. The intensive works on responsive implantable polymeric drug systems had begun in 1980's. These systems are categorized in two different groups:1. ORIGINAL RESEARCH ABSTRACTIn this study, the controlled release tablet of diltiazem hydrochloride was developed. The controlled release tablets were prepared with ethyl cellulose by changing the ratio of diltiazem hydrochloride and the in vitro release studies were carried out by using an ultrasonic water bath. According to release results, a new equation was developed that can be used to estimate the release of drug as a function of time and drug content in the formulation. In addition, the effect of ultrasound on the release of diltiazem hydrochloride from controlled release dosage forms and relationships between release rate constants and drug contents were investigated. This study showed that the developed equation can successfully be used to estimate the effect of ultrasound on the release of drug from the formulations prepared with different concentrations of diltiazem hydrochloride. It was concluded that ultrasound has a very important effect on the release of drug and increases drug release obviously.