A Preliminary Study on the Potential of Manuka Honey and Platelet-Rich Plasma in Wound Healing

Sell, Scott A.; Wolfe, Patricia S.; Spence, Andrew J.; Rodriguez, Isaac A.; McCool, Jennifer M.; Petrella, Rebecca L.; Garg, Koyal; Ericksen, Jeffery J.; Bowlin, Gary L.

doi:10.1155/2012/313781

Cited by 80 publications

(99 citation statements)

References 57 publications

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“…Enhancement of dermal regeneration potential was evident. 56 The effect of wound healing may be a culmination of both the anti-inflammatory effect, anti-microbial as well as immunostimulatory effect of manuka honey. Immuno-stimulation, in particularly the elevated level of cytokine hormones is merited as one mechanism for wound repair.…”

Section: Anti-ulcer and Wound Healingmentioning

confidence: 99%

Manuka honey: an emerging natural food with medicinal use

Patel

Cichello

2013

Nat. Prod. Bioprospect.

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Abstract:The health value of honey is universally acknowledged from time immemorial. Manuka (Leptospermum scoparium) is a tree, indigenous to New Zealand and South East Australia, and from the myrtle family, Myrtaceae. The honey produced from its flowers is a uni-floral honey largely produced in New Zealand. It is becoming increasingly popular as a functional food, seen in the aisles of health stores as its displays superior nutritional and phytochemistry profile over other varieties of honey. Examining existing research databases revealed its biological properties ranging from anti-oxidant, anti-inflammatory, anti-bacterial, anti-viral, anti-biotic and wound healing to immune-stimulatory properties. Methylglyoxal is the unique compound in the honey responsible for some of its potent anti-microbial properties. Further, propolis another component of honey contains chiefly flavonoids (i.e. galangin, pinocembrin), phenolic acids and their esters that may also contribute to its immuno-stimulant properties. Recent findings of the biological roles have been discussed with emphasis on the underlying mechanisms. The hurdles associated in its development as a functional food and also nutraceutical with future scopes have also been mentioned. Relevant data published in MEDLINE, Cochrane library, and EMBASE in the past decade have been gathered to formulate this review.

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Section: Anti-ulcer and Wound Healingmentioning

confidence: 99%

Manuka honey: an emerging natural food with medicinal use

Patel

Cichello

2013

Nat. Prod. Bioprospect.

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“…This leads to ECM reinforcement, fibroblast proliferation, and the synthesis and accumulation of collagen, all of which are essential for wound healing . For horses, PRP application induces more rapid epithelial differentiation, increasing collagen presence, and collagen matrix contraction, causing dense collagen bundles to be oriented parallel to each other and to the overlying epithelium, which is required for wound healing …”

Section: Newer Treatments For Pressure Ulcersmentioning

confidence: 99%

“…These influences appear to result from platelet release of VEGF, PDGF, and TGF‐β3. 72 The influences of PRP are enhanced when it is combined with manuka honey . This suggests that combining PRP with other techniques may induce more rapid and extensive ulcer healing.…”

Section: Newer Treatments For Pressure Ulcersmentioning

confidence: 99%

Improving the ability to eliminate wounds and pressure ulcers

Kuffler

2015

Wound Repair Regeneration

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Pressure ulcers can be initiated by as little as 2 hours of constant pressure on the ski, that blocks blood circulation causing the skin and underlying tissues to die, leading to an open wound that never heals, but continues to grow in diameter and depth, and frequently jeopardizes patients' lives. Despite the application of many diverse techniques, pressure ulcers remain exceptionally difficult to heal because many ulcer elimination techniques have minimal effects, and although other techniques may appear to be effective, the evidence supporting their efficacy is weak. However, increasing evidence indicates that other techniques, such as the application of platelet-rich plasma, vacuum assisted closure, electrical stimulation, and hyperbaric oxygen therapy are effective and should be substituted for the older techniques. This review describes different standard and novel techniques that have been tested for eliminating pressure ulcers and discusses the relative efficacy of these techniques.

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“…Recent research has indicated that lyophilized PRP (i.e. a preparation rich in growth factors, PRGF) may contain a number of MAC phenotype modifying biomolecules (IL-10, lipoxins) [31][32][33]. It has been suggested that PRP possesses the ability to modify the local inflammatory response and stimulate healing in chronic pressure ulcers.…”

Section: Introductionmentioning

confidence: 99%

Using Electrospun Scaffolds to Promote Macrophage Phenotypic Modulation and Support Wound Healing

Hixon¹,

Dunn²,

Flores³

et al. 2017

Electrospinning

Self Cite

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Abstract:The development of pressure ulcers in spinal cord injury patients is extremely common, often requiring extensive surgical procedures. Macrophages (MACs) play a crucial role in the innate immune system, contributing to wound healing and overall regeneration. MACs have been found to possess the potential to be activated by external factors from their M0 inactive state to an M1 proinflammatory or M2 regenerative state. This study conducted a comprehensive evaluation of MAC phenotype in response to electrospun scaffolds of varying material fiber/pore diameter, fiber stiffness, and +/− inclusion of platelet-rich plasma (PRP). Generally, it was found that the addition of PRP resulted in decreased pore size, where 5 silk fibroin (SF) had the stiffest fibers. Furthermore, PRP scaffolds demonstrated an increased production of VEGF and chemotaxis. The polycaprolactone (PCL) and SF scaffolds had the largest cell infiltration and proliferation. Overall, it was found that 5% SF had both ideal fiber and pore structure, allowing for cell infiltration further enhanced by the presence of PRP. Additionally, this scaffold led to a reasonable production of VEGF while still allowing fibroblast proliferation to occur. These results suggest that such a scaffold could provide an off-the-shelf product capable of modifying the local MAC response.

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A Preliminary Study on the Potential of Manuka Honey and Platelet-Rich Plasma in Wound Healing

Cited by 80 publications

References 57 publications

Manuka honey: an emerging natural food with medicinal use

Manuka honey: an emerging natural food with medicinal use

Improving the ability to eliminate wounds and pressure ulcers

Using Electrospun Scaffolds to Promote Macrophage Phenotypic Modulation and Support Wound Healing

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