A preliminary study on polycaprolactone and gelatin-based bilayered tubular scaffolds with hierarchical pore size constructed from nano and microfibers for vascular tissue engineering

Huang, Lin; Guo, Shanzhu; Jiang, Yue; Shen, Quan; Li, Long; Yan, Shi; Xie, Haibo; Tian, Jialiang

doi:10.1080/09205063.2021.1938857

Cited by 8 publications

(4 citation statements)

References 50 publications

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“…Huang et al, in a preliminary study, prepared a bilayered scaffold by electrospinning PCL, polyethylene glycol (PEG), and gelatin. After achieving the optimal material blend for ultrastructure properties, cocultures of SMCs and ECs seeded on the membranes were set up, and the results showed good endothelialization on the surface, cell adhesion, and migration, with the 3D colonization of SMCs on the scaffold [ 116 ]. In 2020, the same research group evaluated, instead, a blend of PCL, PLGA, and gelatin for electrospinning.…”

Section: Natural Biomaterials For Vascular Tissue Engineeringmentioning

confidence: 99%

“…Gelatin was electrospun with PCL and PGE to increase mechanical properties and tailor ultrastructure, achieving cell adhesion and migration in the scaffold and edothelialization. 2017 [116] In vitro Electrospun PCL, PGLA, and gelatin with controlled fiber orientation showing increased guidance for cell orientation and appropriate mechanical properties.…”

Section: [113]mentioning

confidence: 99%

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Biological Materials for Tissue-Engineered Vascular Grafts: Overview of Recent Advancements

Di Francesco,

Pigliafreddo,

Casarella

et al. 2023

Biomolecules

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The clinical demand for tissue-engineered vascular grafts is still rising, and there are many challenges that need to be overcome, in particular, to obtain functional small-diameter grafts. The many advances made in cell culture, biomaterials, manufacturing techniques, and tissue engineering methods have led to various promising solutions for vascular graft production, with available options able to recapitulate both biological and mechanical properties of native blood vessels. Due to the rising interest in materials with bioactive potentials, materials from natural sources have also recently gained more attention for vascular tissue engineering, and new strategies have been developed to solve the disadvantages related to their use. In this review, the progress made in tissue-engineered vascular graft production is discussed. We highlight, in particular, the use of natural materials as scaffolds for vascular tissue engineering.

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Section: Natural Biomaterials For Vascular Tissue Engineeringmentioning

confidence: 99%

Section: [113]mentioning

confidence: 99%

Biological Materials for Tissue-Engineered Vascular Grafts: Overview of Recent Advancements

Di Francesco,

Pigliafreddo,

Casarella

et al. 2023

Biomolecules

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“…Printable hydrogels of a HUVEC‐containing polyrotaxane‐alginate double network were prepared, which showed excellent biocompatibility, especially in terms of survival and proliferation of HUVECs (Y. Liu, Zhang, et al, 2021). A double‐layer scaffold with a layered pore diameter was constructed by electrospinning PCL‐PEG‐PCL and gelatin in sequence, which supported the proliferation of endothelial cells and further endothelialization of the membrane surface (L. Huang, Guo, et al, 2021). The double‐layer scaffold has great potential for vascular remodeling and regeneration.…”

Section: Nanomedicine Approaches In Vascular Diseasesmentioning

confidence: 99%

Nanotechnology translation in vascular diseases: From design to the bench

Zhou,

Yue,

Ding

et al. 2023

WIREs Nanomed Nanobiotechnol

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Atherosclerosis is a systemic pathophysiological condition contributing to the development of majority of polyvascular diseases. Nanomedicine is a novel and rapidly developing science. Due to their small size, nanoparticles are freely transported in vasculature, and have been widely employed as tools in analytical imaging techniques. Furthermore, the application of nanoparticles also allows target intervention, such as drug delivery and tissue engineering regenerative methods, in the management of major vascular diseases. Therefore, by summarizing the physical and chemical characteristics of common nanoparticles used in diagnosis and treatment of vascular diseases, we discuss the details of these applications from cellular, molecular, and in vivo perspectives in this review. Furthermore, we also summarize the status and challenges of the application of nanoparticles in clinical translation.This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Cardiovascular Disease Implantable Materials and Surgical Technologies > Nanomaterials and Implants Therapeutic Approaches and Drug Discovery > Emerging Technologies

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“…While ECs on the luminal surface prevent thrombosis, SMCs on the outer wall of vascular scaffolds support the scaffolds’ activities such as vasoconstriction and vasodilatation [ 53 ]. It is claimed that electrospun scaffolds with fiber diameters of more than 1 μm allow larger pore diameters and encourage cell penetration, whereas smaller fiber diameters of less than 1 μm dramatically restrict diffusion for the majority of cell types, and so the ideal pore diameter necessary for sufficient cellular penetration is greater than 10 μm [ 53 , 54 , 55 ]. Small pore diameters are acceptable for the ECs to accumulate, proliferate, and infiltrate on the graft surface, which encourages ECM regeneration; however, they hinder SMCs’ infiltration and colonization around the neo-vessel [ 53 ].…”

Section: Design Components For Electrospun Vascular Prosthesismentioning

confidence: 99%

An Investigation of the Constructional Design Components Affecting the Mechanical Response and Cellular Activity of Electrospun Vascular Grafts

et al. 2022

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Cardiovascular disease is anticipated to remain the leading cause of death globally. Due to the current problems connected with using autologous arteries for bypass surgery, researchers are developing tissue-engineered vascular grafts (TEVGs). The major goal of vascular tissue engineering is to construct prostheses that closely resemble native blood vessels in terms of morphological, mechanical, and biological features so that these scaffolds can satisfy the functional requirements of the native tissue. In this setting, morphology and cellular investigation are usually prioritized, while mechanical qualities are generally addressed superficially. However, producing grafts with good mechanical properties similar to native vessels is crucial for enhancing the clinical performance of vascular grafts, exposing physiological forces, and preventing graft failure caused by intimal hyperplasia, thrombosis, aneurysm, blood leakage, and occlusion. The scaffold’s design and composition play a significant role in determining its mechanical characteristics, including suturability, compliance, tensile strength, burst pressure, and blood permeability. Electrospun prostheses offer various models that can be customized to resemble the extracellular matrix. This review aims to provide a comprehensive and comparative review of recent studies on the mechanical properties of fibrous vascular grafts, emphasizing the influence of structural parameters on mechanical behavior. Additionally, this review provides an overview of permeability and cell growth in electrospun membranes for vascular grafts. This work intends to shed light on the design parameters required to maintain the mechanical stability of vascular grafts placed in the body to produce a temporary backbone and to be biodegraded when necessary, allowing an autologous vessel to take its place.

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A preliminary study on polycaprolactone and gelatin-based bilayered tubular scaffolds with hierarchical pore size constructed from nano and microfibers for vascular tissue engineering

Cited by 8 publications

References 50 publications

Biological Materials for Tissue-Engineered Vascular Grafts: Overview of Recent Advancements

Biological Materials for Tissue-Engineered Vascular Grafts: Overview of Recent Advancements

Nanotechnology translation in vascular diseases: From design to the bench

An Investigation of the Constructional Design Components Affecting the Mechanical Response and Cellular Activity of Electrospun Vascular Grafts

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