A preliminary study of the Six-Item Screener in detecting cognitive impairment

Abstract

Objective The present retrospective study was to explore the clinical value of Six-Item Screener (SIS), which is constituted by 6 items from mini-mental status examination (MMSE), to identify cognitive impairment. Methods A total number of 1976 patients aged over 50 years, from the Memory Clinic of Huashan Hospital were employed in a battery of neuropsychological tests including MMSE. Subjects with severe conditions, unable to cooperate, or having been previously enrolled, were excluded from this study. The employed subjects were divided into 3 groups: subjective memory complaints (SMCs) (475 cases), patients with mild cognitive impairment (MCI) (440 cases), and patients with Alzheimer's disease (AD) (1061 cases, including 555 mild, 339 moderate, and 167 severe). A total score of MMSE and a score of SIS composed of date, month, year, three-word delayed recall from MMSE were calculated. Data were analyzed based on educational background. ResultsThe cut-off of SIS score was ≤ 2 for illiterate, ≤ 3 for elementary, and ≤ 4 for junior high school or above. The sensitivity and specificity of SIS for detecting mild AD were 88.5% and 78.3%, respectively, with an overall accuracy of 83.8%, while for detecting MCI, the sensitivity and specificity were 34.3% and 90.1%, respectively, with an overall accuracy of 63.2%.Conclusion SIS is an effective and reliable instrument for dementia detection in outpatient department. However, it has limited value for MCI identification.

Telephone-based cognitive screening for stroke patients in china

“…Third, we did not evaluate the test-retest reliability of the instruments, as both tests had wellestablished face-to-face versions (Chen et al, 2010;Wong et al, 2013). First, most patients (66/89, 74.2%) suffered a relatively mild stroke, and those with more severe stroke might encounter difficulty when taking tests.…”

Cross-Cultural Comparison of Successful Aging Definitions Between Chinese and Hmong Elders in the United States

“…The questions in the screener include a three-object recall (apple, table, penny) and three-item temporal orientation (day of the week, month, year). The screener has been shown to be have 83.8% diagnostic accuracy for Alzheimer’s Disease in a Chinese population (Chen, Guo, Cao, Hong, & Liu, 2010). A resource sheet with a list of dementia diagnostic clinics in the region was prepared to be given to the elder if the need arose.…”

Screening a heterogeneous elderly South African population for cognitive impairment: the utility and performance of the Mini-Mental State Examination, Six Item Screener, Subjective Memory Rating Scale and Deterioration Cognitive Observee

“…32 Subsequent studies have been divided on its efficacy with one study yielding lower sensitivities 41 and another finding it a reliable and effective tool for dementia but not MCI detection. 42 In view of the large difference in case identification between the MMSE and the SIS, the relative merits of using the MMSE or the SIS locally is best determined once the validity of the MMSE is established against the gold standard of a clinical diagnosis of cognitive impairment.…”