A Preliminary Study of Silver Sodium Zirconium Phosphate Polyurethane Foam Wound Dressing on Wounds of the Distal Aspect of the Forelimb in Horses

Abstract

The SPF wound dressing improved some measures of wound healing compared with the control dressing, most significantly during the first 30 days. This suggests that the SPF wound dressing may be useful in the early management of wounds on the equine lower limb. Further studies using the SPF dressing are needed to characterize the temporal and cellular effects on wound healing and evaluate this dressing in a clinical environment.

Comparison of the effects of topical application of UMF20 and UMF5 manuka honey with a generic multifloral honey on wound healing variables in an uncontaminated surgical equine distal limb wound model

“…Most experimental studies of equine distal limb wound healing using surgical models have been performed on forelimbs. [1][2][3][4][5][6][7][28][29][30][39][40][41][42] However, the prolonged healing times in this study are consistent with the results of the only other study to investigate distal limb wound healing in equine hindlimbs. 43 That study showed that hindlimb wounds healed significantly slower than forelimb wounds, but the pattern of healing is similar, with wounds initially retracting, followed by a period of consistent and steady contraction.…”

Effects of various wound dressings on microbial growth in perfused equine musculocutaneous flaps

“…Multiple dressings have been developed for human wound care, 4 and several studies [5][6][7][22][23][24] have evaluated their effects on wound healing and influences on microbial growth in clinical settings or in vivo experiments. However, comparative studies 25,26 performed to evaluate multiple dressings under the same circumstances are limited, and the choice of a specific wound dressing is often based on personal preference.…”

“…A silver-containing semiocclusive foam dressing was found to have beneficial effects on wound healing in horses, especially during the first 30 days of treatment, although the complete wound healing time did not differ from that for a control dressing. 7 One clinical study 9 on the use of various topically applied treatments for bandaged wounds in horses found that application of silver sulfadiazine cream resulted in more exuberant granulation tissue formation, compared with a control (no topical treatment). In our study, a more recent nanoparticle silver formulation was used because it is reported to have faster and more prolonged antibacterial activity than silver sulfadiazine, 16,23 but the latter property could not be confirmed in the present study.…”

“…For several available wound dressings and other compounds, the influence on microbial growth in contaminated wounds of horses has been evaluated either in a clinical situation or an experimental setting. [5][6][7][8][9] However, large studies comparing the influence of multiple dressings or compounds on microbial growth are scarce. This type of evaluation can be performed with an in vivo experimental design, but such studies are often expensive and ethical issues may arise.…”

Enhancement of chronic wound healing with maltodextrin/ascorbic acid gel: a clinical evaluation of distal limb wounds in horses

“…Various topical wound therapies have been tested in horses' distal limb models to enhance second-intention wounds, with varying degrees of success [13,15]. Furthermore, several medications had inconclusive outcomes for improving wound healing when compared to the control group [16][17][18][19][20][21]. Thus, equine veterinarians should be aware that positive findings from these research studies have not been replicated consistently when evaluated in vivo on horse wounds [22].…”