A preliminary study of neck-stomach syndrome

Song, Xinghua; Xu, Xinhua; Ding, Liwen; Cao, Li; Sadel, Alken; Wen, Hao

doi:10.3748/wjg.v13.i18.2575

Cited by 5 publications

(3 citation statements)

References 23 publications

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“…Of interest, cervical spondylosis has been recently proposed to induce FGIDs in an experimental rat model. 44 Heart disease has been studied in relation to upper gastrointestinal symptoms, and FD patients appear to more often suffer from circulatory system disease, myocardial infarction, angina, and chest pain. 45 While some risk factors (smoking, obesity, high blood pressure) are known to be common to FD and heart disease, the explanation for the observed comorbidity has often been sought in the side effects of respective pharmacological treatments.…”

Section: Discussionmentioning

confidence: 99%

“…Increased prevalence of rheumatological disorders has been previously reported in FGIDs, 42,43 while spondylosis has not been studied in FD. Of interest, cervical spondylosis has been recently proposed to induce FGIDs in an experimental rat model 44 . Heart disease has been studied in relation to upper gastrointestinal symptoms, and FD patients appear to more often suffer from circulatory system disease, myocardial infarction, angina, and chest pain 45…”

Section: Discussionmentioning

confidence: 99%

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A survey of functional dyspepsia in 361,360 individuals: Phenotypic and genetic cross‐disease analyses

García-Etxebarria

Carbone

Teder‐Laving

et al. 2021

Neurogastroenterology Motil

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Background Functional dyspepsia (FD) is a common gastrointestinal condition of poorly understood pathophysiology. While symptoms’ overlap with other conditions may indicate common pathogenetic mechanisms, genetic predisposition is suspected but has not been adequately investigated. Methods Using healthcare, questionnaire, and genetic data from three large population‐based biobanks (UK Biobank, EGCUT, and MGI), we surveyed FD comorbidities, heritability, and genetic correlations across a wide spectrum of conditions and traits in 10,078 cases and 351,282 non‐FD controls of European ancestry. Key Results In UK Biobank, 281 diagnoses were detected at increased prevalence in FD, based on healthcare records. Among these, gastrointestinal conditions (OR = 4.0, p < 1.0 × 10−300), anxiety disorders (OR = 2.3, p < 1.4 × 10−27), ischemic heart disease (OR = 2.2, p < 2.3 × 10−76), and infectious and parasitic diseases (OR = 2.1, p = 1.5 × 10−73) showed strongest association with FD. Similar results were obtained in an analysis of self‐reported conditions and use of medications from questionnaire data. Based on a genome‐wide association meta‐analysis of genotypes across all cohorts, FD heritability was estimated close to 5% (hSNP2 = 0.047, p = 0.014). Genetic correlations indicate FD predisposition is shared with several other diseases and traits (rg > 0.344), mostly overlapping with those also enriched in FD patients. Suggestive (p < 5.0 × 10−6) association with FD risk was detected for 13 loci, with 2 showing nominal replication (p < 0.05) in an independent cohort of 192 FD patients. Conclusions & Inferences FD has a weak heritable component that shows commonalities with multiple conditions across a wide spectrum of pathophysiological domains. This new knowledge contributes to a better understanding of FD etiology and may have implications for improving its treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A survey of functional dyspepsia in 361,360 individuals: Phenotypic and genetic cross‐disease analyses

García-Etxebarria

Carbone

Teder‐Laving

et al. 2021

Neurogastroenterology Motil

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“…Indeed, it has been previously shown using the NSQIP database that preoperative anemia is an independent risk factor for complications, the need for perioperative blood transfusion, return to the operating room, and extended length of stay after cervical surgery [12,23]. From a different perspective, it has also been proposed through animal studies that spinal cord compression may result in irregular nervous stimulation of the stomach, a phenomenon termed neck-stomach syndrome [24]. However, this connection remains largely unexplored.…”

Section: Discussionmentioning

confidence: 99%

The Relationship Between Gastrointestinal Comorbidities, Clinical Presentation and Surgical Outcome in Patients with DCM: Analysis of a Global Cohort

Nouri

Badhiwala

Kato

et al. 2020

JCM

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Degenerative cervical myelopathy (DCM) is the most common cause of spinal cord impairment in adults, presenting most frequently in patients 50 years or older. Gastrointestinal comorbidities (GICs) commonly occur in this group; however, their relationship with DCM has not been thoroughly investigated. It is the objective of the present study to investigate the difference between patients with or without GICs who are surgically treated for DCM. A cohort of 757 patients with clinical data and 458 with magnetic resonance imaging (MRI) data from the AOSpine North America and AOSpine International studies on DCM was evaluated. GICs were obtained at presentation and included gastric, intestinal, hepatic, and pancreatic conditions. Patients were dichotomized into 2 groups: those with GICs and those without GICs. Both clinical and MRI presentation, as well as baseline neurological and functional status, were compared. Neurological and functional outcomes at 2-year follow-up were also compared. GICs were present in 121 patients (16%). These patients were less commonly male (48.76% vs. 65.4%, p = 0.001) and were slightly less neurologically impaired based on the Nurick grade (3.05 ± 1.10 vs. 3.28 ± 1.16, p = 0.044) but not based on mJOA (12.74 ± 2.62 vs. 12.48 ± 2.76, p = 0.33). They also had a worse physical health score (32.80 ± 8.79 vs. 34.65 ± 9.38 p = 0.049), worse neck disability (46.31 ± 20.04 vs. 38.23 ± 20.44, p < 0.001), a lower prevalence of upper motor neuron signs (hyperreflexia, 70.2% vs. 78.9%, p = 0.037; Babinski’s sign 24.8% vs. 37.3%, p = 0.008), and a higher rate of psychiatric comorbidities (31.4% vs. 10.4%, p < 0.0001). On MRI, GIC patients less commonly exhibited signal intensity changes (T2 hyperintensity, 49.2% vs. 75.6%, p < 0.001; T1 hypointensity, 9.7% vs. 21.1%, p = 0.036), and had a lower number of T2 hyperintensity levels (0.82 ± 0.98 vs. 1.3 ± 1.11, p = 0.001). There was no difference in surgical outcome between the groups. DCM patients with GICs are more likely to be female and have significantly more general health impairment and neck disability. However, these patients have less clinical and MRI features typical of more severe neurological impairment. This constellation of symptoms is considerably different than those typically observed in DCM, and it is therefore plausible that nutritional factors may contribute to this unique observation.

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