A Preliminary Study of Left Atrial Function and Left Atrial Stiffness in Type 2 Diabetic Patients with Normotensive Patients Without Symptomatic Cardiovascular Disease

Abstract

Background: The purpose of this study was to investigate the relationship between left atrial function and left atrial stiffness in type 2 diabetic patients.Methods: A total of 41 healthy subjects (controls) and 39 patients with type 2 diabetes mellitus (DM2 patients) were enrolled in this study. The left atrial volume index was measured by biplanar Simpson method. The early and late diastolic velocities (e'and a') were measured by tissue Doppler in lateral and septal boeder of the mitral annulus. Lateral and septal myocardial velocities were averaged. E/eʹ ratio was computed.The peak atrial longitudinal strain (PALS) was analyzed by tow-dimensional speckle tracking imaging (2D-STI) technique.The ratio of E/e ' to PALS was used as an indicator of LASI.Results:The maximum volume (LAVImax), minimum volume (LAVImin) and pre-contraction volume (LAVIpre) of the left atrium in DM2 patients were significantly higher than those in the control groups, and the differences were statistically significant (P<0.05). The difference between PALS decrease and LASI increase was statistically significant (P<0.05).PALS and LASI were statistically correlated with three phase volume index of left atrial and E/e'ratio. LASI was superior to PALS and left atrial volume index in diagnosing diabetic normotensive patients without symptomatic cardiovascular disease.Conclusion: Compared with the controls, PALS decreased and LASI increased in DM2. PALS and LASI were significantly correlated with left atrial volume and E/e’. LASI showed the highest diagnostic efficacy in the diagnosis of diabetes. PALS and LASI can be used as indicators for early evaluation of left atrial function in patients with DM2.Trial registration number:+86-17856931224;date of registration:May 3,2021