A preliminary study of externally and self-ordered task performance in schizophrenia

Ganzevles, Paul G.J.; Haenen, Marie-Anne

doi:10.1016/0920-9964(94)00061-c

Cited by 9 publications

(6 citation statements)

References 26 publications

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“…Furthermore, the B-G connectivity shows higher correlation in controls than patients, which agrees with previous studies since these components are related to mental timekeeping and self-ordered behavior, commonly disturbed in schizophrenia (Ganzevles and Haenen 1995). Two of the 4 connections among components in which patients show higher correlation than controls relate to component E. This is also consistent with previous studies finding abnormal function of basal ganglia regions in schizophrenia minds show dysfunction and decreased activations in the basal ganglia (Gaser, et al2004;Menon, et al 2001).…”

Section: Component B (Insupporting

confidence: 91%

A method for functional network connectivity among spatially independent resting-state components in schizophrenia

et al. 2008

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Functional connectivity of the brain has been studied by analyzing correlation differences in time courses among seed voxels or regions with other voxels of the brain in healthy individuals as well as in patients with brain disorders. The spatial extent of strongly temporally coherent brain regions co-activated during rest has also been examined using independent component analysis (ICA). However, the weaker temporal relationships among ICA component time courses, which we operationally define as a measure of functional network connectivity (FNC), have not yet been studied. In this study, we propose an approach for evaluating FNC and apply it to functional magnetic resonance imaging (fMRI) data collected from persons with schizophrenia and healthy controls. We examined the connectivity and latency among ICA component time courses to test the hypothesis that patients with schizophrenia would show increased functional connectivity and increased lag among resting state networks compared to controls. Resting state fMRI data were collected and the inter-relationships among seven selected resting state networks (identified using group ICA) were evaluated by correlating each subject's ICA time courses with one another. Patients showed higher correlation than controls among most of the dominant resting state networks. Patients also had slightly more variability in functional connectivity than controls. We present a novel approach for quantifying functional connectivity among brain networks identified with spatial ICA. Significant differences between patient and control connectivity in different networks were revealed possibly reflecting deficiencies in cortical processing in patients.

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Section: Component B (Insupporting

confidence: 91%

A method for functional network connectivity among spatially independent resting-state components in schizophrenia

et al. 2008

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“…A number of additional features of the persons with psychiatric morbidity, however, need to be taken into consideration. For example, in persons with schizophrenia, decreased cognitive functioning particularly affects working memory [24]. In addition there is limited normalization of cognitive functioning which may indicate a residual deficit intrinsic to schizophrenia [25].…”

Section: Discussionmentioning

confidence: 99%

Impediments to screening for hazardous alcohol use and dependence in general hospital psychiatric inpatients

Hulse

2001

Aust N Z J Psychiatry

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Failure to screen patients was largely due to short hospital stays. Screening was impeded by the brief window period, commonly 1 or 2 days, between the absence of acute psychiatric sequelae and discharge. This situation contrasts dramatically to the medical or surgical admission where major sequelae are largely resolved in 2-3 days and AUDIT screening can take place over the remaining 3-4 days prior to discharge. To be effective in the general hospital psychiatric setting, alcohol screening needs to be incorporated into the routine ward assessment procedures. The brevity of the AUDIT makes this possible. This would maximize the time available to implement an intervention programme to those found to be consuming alcohol at a hazardous or harmful level.

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“…The current literature on SOPT [ 15 - 17 ] and VCALT [ 18 - 20 ] consistently supports the presence of deficits in schizophrenia patients versus healthy controls. However, these studies frequently involved small samples, utilized broad diagnostic criteria, included patients taking antipsychotic medications, and did not control for symptom domains, severity of the disorder and other putative sources of variation.…”

Section: Introductionmentioning

confidence: 85%

“…Indeed, the sample of patients and controls was sizeable; the selection criteria limited the recruitment a priori to a rather clinically homogeneous group of patients, and a discrete number of possible demographic and clinical confounders had been statistically controlled. Given that important limitations inherent in many pre-existing studies on the same tasks [ 15 - 20 ] have been bypassed, the conclusion that a large preponderance of intellectually normal, non-deteriorated, antipsychotic drug-free schizophrenia spectrum disorder patients with a florid phase of psychosis dominated by positive symptoms have evident SOPT and VCALT deficits seems therefore fully supported.…”

Section: Discussionmentioning

confidence: 99%

Self-ordered pointing and visual conditional associative learning tasks in drug-free schizophrenia spectrum disorder patients

et al. 2008

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Background: There is evidence of a link between schizophrenia and a deficit of working memory, but this has been derived from tasks not specifically developed to probe working memory per se. Our aim was to investigate whether working memory deficits may be detected across different paradigms using the self-ordered pointing task (SOPT) and the visual conditional associative learning task (VCALT) in patients with schizophrenia spectrum disorders and healthy controls. The current literature suggests deficits in schizophrenia spectrum disorder patients versus healthy controls but these studies frequently involved small samples, broad diagnostic criteria, inclusion of patients on antipsychotic medications, and were not controlled for symptom domains, severity of the disorder, etc. To overcome some of these limitations, we investigated the self-monitoring and conditional associative learning abilities of a numerically representative sample of healthy controls and a group of nondeteriorated, drug-free patients hospitalized for a schizophrenia spectrum disorder with florid, mainly positive psychotic symptoms.

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A preliminary study of externally and self-ordered task performance in schizophrenia

Cited by 9 publications

References 26 publications

A method for functional network connectivity among spatially independent resting-state components in schizophrenia

A method for functional network connectivity among spatially independent resting-state components in schizophrenia

Impediments to screening for hazardous alcohol use and dependence in general hospital psychiatric inpatients

Self-ordered pointing and visual conditional associative learning tasks in drug-free schizophrenia spectrum disorder patients

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