A preliminary study of dietary aluminium intake and risk of Alzheimer's disease

Rogers, Mary A.M.; Simon, Donald

doi:10.1093/ageing/28.2.205

Cited by 119 publications

(56 citation statements)

References 24 publications

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“…In other studies, the difficulty regarding the detection of the relationship between Al concentration and AD in epidemiological studies is highlighted. It is also reported that the potential of Al existence found in some foods and in medicines, as well as in drinking water, could be a confusing factor (Rogers and Simon 1999). In 2001, Flatten performed an analysis of the studies investigating the relationship between Al levels found in the drinking water versus AD and dementia diseases seen in the local people.…”

Section: Discussionmentioning

confidence: 99%

Effect of High Aluminum Concentration in Water Resources on Human Health, Case Study: Biga Peninsula, Northwest Part of Turkey

Bakar

Karaman

Baba

et al. 2009

Arch Environ Contam Toxicol

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Widespread and intense zones of silicified, propylitic, and argillic alteration exist as outcrop around the Biga Peninsula, NW Turkey. Most of the springs in the study area surface out from these altered volcanic rocks. The concentrations of aluminum (Al) in these springs ranged from 13.17 to 15.70 ppm in this region. These high levels of Al were found to exceed the maximum allowable limits (0.2 ppm) depicted in national and international standards of drinking water quality. Therefore, the effect of high Al in water resources on human health was evaluated in this research. A total of 273 people aged above 18 years and living in the Kirazli region (whose water supply is from springs emerging from these alteration zones) and in the Ciplak-Halileli region (whose water supply is provided from an alluvium aquifer) were selected as the research group. For this group, a questionnaire was completed that contained questions on descriptive characteristics of humans and a Mini-Mental State Examination (MMSE) was administered by the authors using the face-to-face interview technique. A neurological examination was then performed by the neurology specialist as a second-stage investigation. Finally, 10 ml of venous blood samples were obtained from these people as a third-stage analysis to determine the serum Al levels together with vitamin B 12 , folic acid, and thyroidstimulating hormone parameters. The result typically revealed that the MMSE score was less in 31.9% and there was no statistically significant difference between the two regions. However, the result also showed that neuropathy in the history (including a careful past medical history) was significantly higher in the Kirazli region.

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Section: Discussionmentioning

confidence: 99%

Effect of High Aluminum Concentration in Water Resources on Human Health, Case Study: Biga Peninsula, Northwest Part of Turkey

Bakar

Karaman

Baba

et al. 2009

Arch Environ Contam Toxicol

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“…It was demonstrated in an epidemiological study that individuals who used to ingest food with high Al contents presented a two times higher risk of developing AD (14) .…”

Section: Inmentioning

confidence: 99%

Aluminum as a risk factor for Alzheimer's disease

Ferreira

Piai

Takayanagui

et al. 2008

Rev. Latino-Am. Enfermagem

168

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“…Increased aluminium concentrations were found in the brains of deceased Alzheimer's patients. Other studies, however, have been unable to find definite indications supporting the hypothesis that aluminium plays a causative role in Alzheimer's disease or causes pathological alterations in vivo in the species studied [14][15][16][17][18][19][20].…”

Section: Introduction and Objectivementioning

confidence: 99%

Aluminium content of selected foods and food products

Taschan²,

2011

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For many years aluminium was not considered harmful to human health because of its relatively low bioavailability. In 1965, however, animal experiments suggested a possible connection between aluminium and Alzheimer's disease. Oral intake of foodstuffs would appear to be the most important source of aluminium. Consequently, the joint FAO/WHO Expert Committee on Food Additives reduced the provisional tolerable weekly intake value for aluminium from 7 mg kg -1 body weight/week to 1 mg kg -1 body weight/week. Analysis of aluminium content of a number of foods and food products was therefore undertaken in order to evaluate the nutritional intake of aluminium. A total of 1,431 samples were analysed within the scope of this study. The data obtained allow a preliminary but current depiction of the aluminium content of selected non-animal foods, food products and beverages.

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A preliminary study of dietary aluminium intake and risk of Alzheimer's disease

Cited by 119 publications

References 24 publications

Effect of High Aluminum Concentration in Water Resources on Human Health, Case Study: Biga Peninsula, Northwest Part of Turkey

Effect of High Aluminum Concentration in Water Resources on Human Health, Case Study: Biga Peninsula, Northwest Part of Turkey

Aluminum as a risk factor for Alzheimer's disease

Aluminium content of selected foods and food products

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