A Preliminary Study of Adjunctive Nonconvulsive Electrotherapy for Treatment-Refractory Depression

Zheng, Wei; Jiang, Miaoling; He, Hongbo; Li, Ripeng; Li, Qilong; Zhang, Chunping; Zhou, Sumiao; Yan, Su; Ning, Yuping; Xiong, Hui

doi:10.1007/s11126-020-09798-3

Cited by 8 publications

(11 citation statements)

References 38 publications

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“…The main purpose of investigating iTBS is to monitor its neurocognitive effects, which has been achieved via multiple neurotherapeutic strategies including magnetic seizure therapy (MST), transcranial direct current stimulation (tDCS) and nonconvulsive electrotherapy (NET) [ 32 ]. Several studies have found that NET appears to be effective as an adjunct treatment in schizophrenia [ 32 ] and treatment-refractory unipolar and bipolar depression [ 33 , 34 , 35 ] without serious associated neurocognitive impairments. However, the findings of the two RCTs [ 23 , 24 ] included in this systematic review on the neurocognitive effects of adjunctive iTBS for older adults with schizophrenia were inconsistent.…”

Section: Discussionmentioning

confidence: 99%

A Systematic Review of Intermittent Theta Burst Stimulation for Neurocognitive Dysfunction in Older Adults with Schizophrenia

Zhang

Yang

Shi

et al. 2023

JPM

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Objective: Neurocognitive dysfunction is thought to be one of the core clinical features of schizophrenia, and older adults with schizophrenia exhibited greater overall cognitive deficits than younger adults. The aim of this systematic review was to examine the neurocognitive effects of intermittent theta burst stimulation (iTBS) as an adjunctive treatment for older adults suffering from schizophrenia. Methods: Randomized double-blinded controlled trials (RCTs) investigating the neurocognitive effects of adjunctive active iTBS versus sham iTBS in older adults with schizophrenia were systematically identified by independent investigators searching Chinese and English databases. Results: Two double-blinded RCTs (n = 132) compared the neurocognitive effects of adjunctive active iTBS (n = 66) versus sham iTBS (n = 66) in patients that fulfilled the inclusion criteria of this systematic review and were analyzed. One RCT found significant superiority of active iTBS over sham iTBS in improving neurocognitive performance in older adults with schizophrenia. In the other RCT, the findings on the neurocognitive effects of iTBS as measured by three different measurement tools were inconsistent. The dropout rate was reported in the two RCTs, ranging from 3.8% (3/80) to 7.7% (4/52). Conclusion: There is preliminary evidence that adjunctive iTBS may have some beneficial effects in the treatment of neurocognitive function in older patients with schizophrenia. Future RCTs with larger sample sizes focusing on the neurocognitive effects of adjunctive iTBS in older adults with schizophrenia are warranted to verify these findings.

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Section: Discussionmentioning

confidence: 99%

A Systematic Review of Intermittent Theta Burst Stimulation for Neurocognitive Dysfunction in Older Adults with Schizophrenia

Zhang

Yang

Shi

et al. 2023

JPM

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“…Thus, more studies need to be performed to determine the neurocognitive effects of MST in schizophrenia. Interestingly, several clinical trials have shown non-convulsive electrotherapy to be effective for individuals suffering from schizophrenia ( 15 ) and TRD ( 48 , 49 ) without associated adverse neurocognitive effects. However, no head-to-head studies have been published that compare the efficacy and safety of MST and non-convulsive electrotherapy in treating schizophrenia.…”

Section: Discussionmentioning

confidence: 99%

Adjunctive Magnetic Seizure Therapy for Schizophrenia: A Systematic Review

et al. 2022

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Objective: The efficacy and safety of adjunctive magnetic seizure therapy (MST) for patients with schizophrenia are unclear. This systematic review was conducted to examine the efficacy and safety of adjunctive MST for schizophrenia.Methods: Chinese (WanFang and Chinese Journal Net) and English (PubMed, EMBASE, PsycINFO, and the Cochrane Library) databases were systematically searched.Results: Two open-label self-controlled studies (n = 16) were included and analyzed in this review. In these studies, the Positive and Negative Syndrome Scale (PANSS) total scores and Brief Psychiatric Rating Scale (BPRS) total scores significantly decreased from baseline to post-MST (all Ps < 0.05), without serious adverse neurocognitive effects. Mixed findings on the neurocognitive effects of adjunctive MST for schizophrenia were reported in the two studies. A discontinuation rate of treatment of up to 50% (4/8) was reported in both studies. The rate of adverse drug reactions (ADRs) was evaluated in only one study, where the most common ADRs were found to be dizziness (25%, 2/8) and subjective memory loss (12.5%, 1/8).Conclusion: There is inconsistent evidence for MST-related adverse neurocognitive effects and preliminary evidence for the alleviation of psychotic symptoms in schizophrenia.

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“…To date, satisfactory results have been achieved in clinical applications[ 5 ]. Nonconvulsive electrotherapy (NET) is a novel method to improve nonconvulsive electroconvulsive therapy that aims to stimulate brain neurons without causing systemic convulsions[ 6 ]. The stimulation intensity of NET is between those of nonconvulsive electroconvulsive therapy and transcranial magnetic stimulation, and the side effects of the treatment are greatly reduced.…”

Section: Introductionmentioning

confidence: 99%

Clinical effects of nonconvulsive electrotherapy combined with mindfulness-based stress reduction and changes of serum inflammatory factors in depression

Gu,

Zhang,

Chen

et al. 2024

World J Psychiatry

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BACKGROUND Depression is a common and serious psychological condition, which seriously affects individual well-being and functional ability. Traditional treatment methods include drug therapy and psychological counseling; however, these methods have different degrees of side effects and limitations. In recent years, nonconvulsive electrotherapy (NET) has attracted increasing attention as a noninvasive treatment method. However, the clinical efficacy and potential mechanism of NET on depression are still unclear. We hypothesized that NET has a positive clinical effect in the treatment of depression, and may have a regulatory effect on serum inflammatory factors during treatment. AIM To assess the effects of NET on depression and analyze changes in serum inflammatory factors. METHODS This retrospective study enrolled 140 patients undergoing treatment for depression between May 2017 and June 2022, the observation group that received a combination of mindfulness-based stress reduction (MBSR) and NET treatment (n = 70) and the control group that only received MBSR therapy (n = 70). The clinical effectiveness of the treatment was evaluated by assessing various factors, including the Hamilton Depression Scale (HAMD)-17, self-rating idea of suicide scale (SSIOS), Pittsburgh Sleep Quality Index (PSQI), and levels of serum inflammatory factors before and after 8 wk of treatment. The quality of life scores between the two groups were compared. Comparisons were made using t and χ2 tests. RESULTS After 8 wk of treatment, the observation group exhibited a 91.43% overall effectiveness rate which was higher than that of the control group which was 74.29% (64 vs 52, χ2 = 7.241; P < 0.05). The HAMD, SSIOS, and PSQI scores showed a significant decrease in both groups. Moreover, the observation group had lower scores than the control group (10.37 ± 2.04 vs 14.02 ± 2.16, t = 10.280; 1.67 ±0.28 vs 0.87 ± 0.12, t = 21.970; 5.29 ± 1.33 vs 7.94 ± 1.35, t = 11.700; P both < 0.001). Additionally, there was a notable decrease in the IL-2, IL-1β, and IL-6 in both groups after treatment. Furthermore, the observation group exhibited superior serum inflammatory factors compared to the control group (70.12 ± 10.32 vs 102.24 ± 20.21, t = 11.840; 19.35 ± 2.46 vs 22.27 ± 2.13, t = 7.508; 32.25 ± 4.6 vs 39.42 ± 4.23, t = 9.565; P both < 0.001). Moreover, the observation group exhibited significantly improved quality of life scores compared to the control group (Social function: 19.25 ± 2.76 vs 16.23 ± 2.34; Emotions: 18.54 ± 2.83 vs 12.28 ± 2.16; Environment: 18.49 ± 2.48 vs 16.56 ± 3.44; Physical health: 19.53 ± 2.39 vs 16.62 ± 3.46; P both < 0.001) after treatment. CONCLUSION MBSR combined with NET effectively alleviates depression, lowers inflammation (IL-2, IL-1β, and IL-6), reduces suicidal thoughts, enhances sleep, and improves the quality of life of individuals with depression.

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A Preliminary Study of Adjunctive Nonconvulsive Electrotherapy for Treatment-Refractory Depression

Cited by 8 publications

References 38 publications

A Systematic Review of Intermittent Theta Burst Stimulation for Neurocognitive Dysfunction in Older Adults with Schizophrenia

A Systematic Review of Intermittent Theta Burst Stimulation for Neurocognitive Dysfunction in Older Adults with Schizophrenia

Adjunctive Magnetic Seizure Therapy for Schizophrenia: A Systematic Review

Clinical effects of nonconvulsive electrotherapy combined with mindfulness-based stress reduction and changes of serum inflammatory factors in depression

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