A preliminary screening of genetic lineage of Nigerian local chickens based on blood protein polymorphisms

Adeleke, Matthew Adekunle; Peters, Sunday O.; Ozoje, M. O.; Ikeobi, C. O. N.; Adebambo, A.O.; Olowofeso, O.; Bamgbose, A. M.; Adebambo, O. A.

doi:10.1017/s2078633610000962

Cited by 17 publications

(8 citation statements)

References 10 publications

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“…In other words, the Normal feather and Frizzle feather populations were probably closely related to each other than the Naked Neck population which was found in a separate sub-clade. Interestingly, this result supported reports from previous studies that used different microsatellite markers (Ohwojakpor et al, 2012) and biochemical markers (Adeleke et al, 2011).…”

Section: Discussionsupporting

confidence: 91%

Genetic variation of the major histocompatibilty complex-B haplotypes in Nigerian local chicken populations

Olufowobi

Ilori

Olowofeso

et al. 2020

Agricultura Tropica Et Subtropica

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To understand the genetic basis and mechanism underlying the differences in the level of immunity among and within chicken populations in Nigeria, it is important to start from the Major Histocompability Complex (MHC) region particularly as it serves as a reservoir for genes of the immune system. The B-complex of chicken major histocompatibility complex, located on microchromosome 16, consists of gene classes responsible for immunity through antigen presentation to T cells. A highly polymorphic tandem repeat marker (LEI0258) located within the B-complex has been a marker of choice for genotyping to identify major histocompatibility complex-B haplotypes and to study the genetic diversity of chicken populations. This study was carried out to determine the genetic variations, at the LEI0258 locus, in three Nigerian local chicken populations; Normal feather, Frizzle feather and Naked neck. The allelic and genotypic profiles of each representative from each population were determined through polymerase chain reaction amplification of the repeat region. The genetic diversity parameters, analysis of molecular variance and evolutionary relationship were determined using GenAlex, FSTAT, Arlequin and POPTREEW, respectively. 76 % of the entire population was heterozygous at the LEI0258 locus. Analysis of molecular variance revealed that large proportion of the total variations across populations was due to variation between individuals (79 %), whereas variations among the populations and among individuals within populations only accounted for less than 1 % and 21 %, respectively. Using Anak Titan as an exotic outgroup, the evolutionary relationship among the Nigerian local chicken populations was studied and a Nei-based dendrogram showed two major clades separating the exotic population from the Nigerian local chicken populations. The identified diversity at the locus could be exploited for usage in further breeding programmes especially for disease resistance and fitness in locally adapted chicken populations in Nigerian.

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Section: Discussionsupporting

confidence: 91%

Genetic variation of the major histocompatibilty complex-B haplotypes in Nigerian local chicken populations

Olufowobi

Ilori

Olowofeso

et al. 2020

Agricultura Tropica Et Subtropica

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“…The lines belonging to the Pirbright Institute are inbred chickens that have been housed in sterile conditions only for laboratory use (Additional file 1: Table S1). The Nigerian and Ethiopian samples are indigenous chickens from small villages and grown in captivity [9]. The Nigerian indigenous chickens are left to roam in the village, feed from picking earthworms, insects, herbage, household refuse, crop residues, seeds from the ground or in farms and return in the evening to their enclosures.…”

Section: Methodsmentioning

confidence: 99%

Comparative analysis of the chicken IFITM locus by targeted genome sequencing reveals evolution of the locus and positive selection in IFITM1 and IFITM3

et al. 2019

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Background The interferon-induced transmembrane (IFITM) protein family comprises a class of restriction factors widely characterised in humans for their potent antiviral activity. Their biological activity is well documented in several animal species, but their genetic variation and biological mechanism is less well understood, particularly in avian species. Results Here we report the complete sequence of the domestic chicken Gallus gallus IFITM locus from a wide variety of chicken breeds to examine the detailed pattern of genetic variation of the locus on chromosome 5 , including the flanking genes ATHL1 and B4GALNT4 . We have generated chIFITM sequences from commercial breeds (supermarket-derived chicken breasts), indigenous chickens from Nigeria (Nsukka) and Ethiopia, European breeds and inbred chicken lines from the Pirbright Institute, totalling of 206 chickens. Through mapping of genetic variants to the latest chIFITM consensus sequence our data reveal that the chIFITM locus does not show structural variation in the locus across the populations analysed, despite spanning diverse breeds from different geographic locations. However, single nucleotide variants (SNVs) in functionally important regions of the proteins within certain groups of chickens were detected, in particular the European breeds and indigenous birds from Ethiopia and Nigeria. In addition, we also found that two out of four SNVs located in the chIFITM1 (Ser36 and Arg77) and chIFITM3 (Val103) proteins were simultaneously under positive selection. Conclusions Together these data suggest that IFITM genetic variation may contribute to the capacities of different chicken populations to resist virus infection. Electronic supplementary material The online version of this article (10.1186/s12864-019-5621-5) contains supplementary material, which is available to authorized users.

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“…The authors also inferred that the YE IC populations were still under natural selection. Adeleke et al [104] had reported mean genetic similarity index of 55% between normal feathered, frizzle feathered and naked neck IC genotypes using blood protein polymorphisms and inferred clearly separated genotypes with naked neck genotype being the most diverged.…”

Section: Genetic Diversity and Distance Within And Between Ecotypes And Genotypesmentioning

confidence: 99%

Utilization and Conservation of Landrace Chickens of Nigeria: Physical and Performance Characteristics, Issues and Concerns

Ogbu¹

2021

Landraces - Traditional Variety and Natural Breed

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The Nigerian indigenous chickens (NICs) are a critical component of the global animal genetic resources. They are distributed in rural areas, kept by the majority of the rural poor. They constitute different strains, or ecotypes local to tribes, regions, or ecological zones and are valued for their disease resistance, adaptation, and yield of valuable products and income on marginal inputs making them a low risk species. They are hence a unique and vital genetic resource and gene pool for present and long-term genetic improvement and human need for food and sustenance. The NIC is however; threatened by extinction owing to neglect, negative selection, breed substitution, and genetic introgression. There is need to draw research and policy attention to the conservation of NICs in accord with the global effort for the conservation of indigenous chickens which is probably the most neglected among farm animal species. The present review therefore, focuses on the physical and performance characteristics, genetic diversity and improvement, utilization and conservation of NIC genetic resources.

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A preliminary screening of genetic lineage of Nigerian local chickens based on blood protein polymorphisms

Cited by 17 publications

References 10 publications

Genetic variation of the major histocompatibilty complex-B haplotypes in Nigerian local chicken populations

Genetic variation of the major histocompatibilty complex-B haplotypes in Nigerian local chicken populations

Comparative analysis of the chicken IFITM locus by targeted genome sequencing reveals evolution of the locus and positive selection in IFITM1 and IFITM3

Utilization and Conservation of Landrace Chickens of Nigeria: Physical and Performance Characteristics, Issues and Concerns

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