A preliminary report on the association between maternal serum organophosphate ester concentrations and gestational diabetes mellitus

Jin, Hangbiao; Gao, Yu; Chen, Rongrong; Zhang, Yingying; Qu, Jianli; Bai, Xuefeng; Zhao, Meirong

doi:10.1016/j.heliyon.2023.e14302

Cited by 3 publications

(2 citation statements)

References 47 publications

(68 reference statements)

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“…The median concentrations of serum TDCPP, TOCP, TNBP, TBOEP, TIBP, and TCIPP in GDM were significantly higher than those in the non-GDM group. However, only TBOEP (OR 2.63; 95% CI 1.68, 4.11), TNBP (OR 2.07; 95% CI 1.27, 3.41), and TPHP (OR 1.03; 95% CI 1.05, 1.51) were associated with GDM, in which the authors attributed to a smaller sample size of controls than the GDM group (130 GDM and 67 controls) 27 . Studies have shown that TPHP have reproductive, developmental, endocrine, and metabolic toxicity 45 , 46 .…”

Section: Discussionmentioning

confidence: 96%

“…In this study, urinary tributyl phosphate (TBP), tris (2-butoxyethyl) phosphate (TBEP), tris (2-chloroethyl) phosphate (TCEP), tris (1,3-dichloro-2-propyl) phosphate (TDCPP), tri-m-cresyl phosphate (TMCP), tri-ortho-cresyl phosphate (TOCP), and triphenyl phosphate (TPHP) during early pregnancy were determined based on a nested case–control study. These OPFRs are the major species exposed in the Chinese population 26 , 27 . This study aimed to examine the association between environmental exposure to OPFRs and GDM, using weighted quantile regression (WQS) and Bayesian kernel machine regression (BKMR) analyses.…”

Section: Introductionmentioning

confidence: 99%

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Environmental exposures to organophosphorus flame retardants in early pregnancy and risks of gestational diabetes mellitus: a nested case–control study

Lang,

Sun,

et al. 2024

Sci Rep

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OPFRs are emerging environmental pollutants with reproductive and endocrine toxicity. This study aimed to examine the association between environmental exposure to OPFRs during early pregnancy and GDM. This nested case–control study was based on a birth cohort that was constructed at a maternal and child health hospital, including 74 cases of GDM among 512 pregnant women. The OPFRs, including TBP, TBEP, TCEP, TDCPP, TMCP, TOCP, and TPHP during 10–14 weeks of pregnancy were determined using GC–MS. The association between the OPFRs and GDM was assessed using WQS and BKMR models. The levels of OPFRs were significantly elevated in GDM patients (60) compared with the controls (90). The WQS analysis showed that mixtures of the OPFRs were significantly associated with GDM (OR 1.370, 95% CI 1.036–1.810, P = 0.027), and TBP, TPHP, and TMCP were the major contributors to the mixed exposure effect. In the BKMR model, individual exposure to TBP, TPHP, and TMCP, and the interaction of TMCP with TBP and TPHP were significantly associated with GDM. Environmental exposure to OPFRs is positively associated with GDM. These findings provide evidence for the adverse effects of OPFR exposure on the health of pregnant women.

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%