A preliminary report on oocyte donation extending reproductive potential to women over 40

Sauer, M.V.; Paulson, RJ; Ra, Lobo

doi:10.1016/0020-7292(91)90302-l

Cited by 10 publications

(11 citation statements)

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“…It is likely that an inadequate ovarian response, and suboptimal endometrial priming, is more specifically related to reduced endometrial receptivity than age alone. Advancing maternal age predisposes to an inadequate ovarian response to IVF stimulation (3, 23), but this inadequate response is not the prerogative of older patients (2,19). It thus follows that donor oocyte or embryo regimes cannot be used to enhance the endometrial receptivity of older patients unless a previous inadequate response to IVF treatment has been demonstrated.…”

Section: Discussionmentioning

confidence: 99%

The selection criteria on an IVF program can remove the association between maternal age and implantation

Arthur

Anthony

Masson

et al. 1994

Acta Obstet Gynecol Scand

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Section: Discussionmentioning

confidence: 99%

The selection criteria on an IVF program can remove the association between maternal age and implantation

Arthur

Anthony

Masson

et al. 1994

Acta Obstet Gynecol Scand

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“…51 The main factor affecting the outcome, is the age of the donor woman. 7,39,53,56,[58][59][60][61][62][63][64] Hence, if oocytes are donated by young women to older women, both embryo implantation and pregnancy rates are restored to normal levels in the recipients, irrespective of their age. Egg donation seems to be the most reliable option of the perimenopausal woman, since the cumulative birth rates after four treatment cycles is >80%.…”

Section: Oocyte Donationmentioning

confidence: 99%

“…Egg donation seems to be the most reliable option of the perimenopausal woman, since the cumulative birth rates after four treatment cycles is >80%. 7,8,39,56,64 Moreover, the best results have been demonstrated after fresh embryo transfer 56 (FIG. 4).…”

Section: Oocyte Donationmentioning

confidence: 99%

Perimenopausal Conception

Tarlatzis

Zepiridis

2003

Annals of the New York Academy of Sciences

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Fertility, defined as the ability to achieve a pregnancy, declines gradually over the woman's lifespan. Although this decline seems to begin from the age of 30 years, it is more obvious between 35 and 40 and increases dramatically thereafter. The age of 41 is considered to be the point when fertility stops and sterility starts. The actual menopause occurs approximately 10 years after the substantial loss of conception potential. Thus, the biological rather than the chronological age of the woman can predict more accurately her fertility potential. This decline in female reproductive potential correlates with ovarian factors, although a slight contribution from the uterus itself and from the neuroendocrine axis cannot be excluded. The ovarian reserve decreases with advancing age, while a parallel decrease in the quality of the oocytes is present, as indicated by the increased incidence of oocyte aneuploidy. The endocrine function of the ovary also declines with age, the later becoming unable to sustain its normal function in the neuroendocrine axis. Additionally, the role of the various endometrial factors remains controversial. On the other hand, exposure to toxic factors and the increased prevalence of infertility-related diseases like endometriosis and PID, may also contribute. Spontaneous conception rates are minimal in perimenopausal women, mainly due to a qualitative and quantitative loss of female gametes. In the rare case of spontaneous conception achievement, complications are more likely. The application of classic ovulation induction and IVF may serve some selected cases, where the woman's ovarian biological age does not correspond to her chronological one. However, the implantation, clinical pregnancy, and live birth rates in women of advanced age undergoing IVF treatment, show very poor results. On the other hand, preimplantation genetic diagnosis is an accurate diagnostic tool for exclusion of genetically deficient embryos prior to embryo transfer. Oocyte donation seems to be the most reliable option of the perimenopausal woman, since the cumulative birth rates after four treatment cycles is approximately 80%. Cryopreservation of ovarian tissue may be an alternative in nulliparas women <40 years of age who want to have children in the future or women with the same desire who, unfortunately, have had pelvic radiotherapy, chemotherapy, oophorectomy, or premature menopause. This technique has given encouraging results in animals, but has not achieved pregnancies in humans. In the future, the use of drugs to block oocyte depletion as well as recent techniques, such as cytoplasmic or germinal vesicle transfer, will be more widely tested and may offer an option to the perimenopausal woman who wishes to conceive.

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“…The claim that a woman's age seriously affects the success rate of donor egg IVF is false. IVF has a very low success rate in itself (Corea and de Wit 1989); with the use of hormones to enrich a post-menopausal woman's uterus and the donation of oocytes to increase her chances of embryo implantation and gestation, her chances of live birth rival that of her younger counterpart (Sauer, Paulson, and Lobo 1990). Indeed, some IVF centers have had relatively successful results in achieving pregnancy among post-menopausal women.…”

Section: Scarcity Of Resourcesmentioning

confidence: 99%

On the Use of IVF by Post-menopausal Women

Parks¹

1999

Hypatia

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Nonfeminist accounts of postmenopausal IVF reject the practice on four main grounds: 1) scarcity of resources; 2) fairness; 3 ) the "inappropriateness" of postmenopausal motherhood; and 4) concerns for orphaned children. I argue that these grounds are insufficient for denying post-menopausal women IVF access. I then suggest that a feminist evaluation of the practice is more compelling; ultimately, however, we have no strong grounds for a policy denying postmenopausal women clccess to this technology.

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A preliminary report on oocyte donation extending reproductive potential to women over 40

Cited by 10 publications

References 0 publications

The selection criteria on an IVF program can remove the association between maternal age and implantation

The selection criteria on an IVF program can remove the association between maternal age and implantation

Perimenopausal Conception

On the Use of IVF by Post-menopausal Women

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