A Preliminary Report on Cleft Deformities of the Face and associated Anomalies in Abha, Saudi Arabia

Togoo, Rafi Ahmad; Yaseen, Syed Mohammad; Zakirulla, M; AlMohy, Ahmad; Alqahtani, Jaber S; Yadav, Neelam

doi:10.5005/jp-journals-10026-1039

Cited by 6 publications

(6 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other studies showed incidence of 24% of cleft lip and palate, 60% of cleft palate, and 16% of cleft lip. 10 Out of 510 children, the majority, 446 (87.5%) were nonsyndromic and 64 (12.5%) were syndromic. In comparison, the study done by Murthy et al showed that 70% of children were non-syndromic and 30% children were syndromic.…”

Section: Discussionmentioning

confidence: 99%

A cross-sectional study of cardiac anomalies among children with orofacial cleft - role of echocardiography

Priyadharshini

James

Rathinasamy

et al. 2017

Int J Contemp Pediatr

View full text Add to dashboard Cite

Background: Orofacial cleft is one of the most common congenital facial abnormalities. Congenital heart disease (CHD) has been reported in up to 15% of the patients with orofacial clefts. Clinical cardiac examinations may sometime miss cardiac anomalies in children with orofacial clefts. The aim of our study is to find out CHD by echocardiography and to correlate this with clinical examination findings in children with orofacial clefts.Methods: In this cross-sectional study, 510 patients with orofacial clefts aged 1 month to 18 years were enrolled. History and clinical examination were performed and data entered in a pre-validated proforma. The type of orofacial cleft and syndromic features was specifically noted. Echocardiography was performed for all patients by a paediatric cardiologist and the clinical cardiovascular findings were correlated with the echocardiogram.Results: The commonest deformity was cleft lip and palate (69%), followed by isolated cleft palate (20.4%), and isolated cleft lip (10.6%). In our study population, 87.5% were non-syndromic and 12.5% were syndromic; 21.9% had cardiac anomaly, of which in 7.8% no cardiac defect was detected during systemic cardiovascular examination but their echocardiogram showed cardiac abnormality. This was statistically significant (p<0.000). Atrial Septal Defect was the commonest anomaly in both the groups. Pierre Robin Syndrome was found to be the commonest syndrome.Conclusions: The high prevalence of CHD among children with orofacial clefts in this study justifies the need for screening echocardiography because many times cardiac anomalies might not be detected in routine systemic examination.

show abstract

Section: Discussionmentioning

confidence: 99%

A cross-sectional study of cardiac anomalies among children with orofacial cleft - role of echocardiography

Priyadharshini

James

Rathinasamy

et al. 2017

Int J Contemp Pediatr

View full text Add to dashboard Cite

show abstract

“…1 Regionally, our findings, 0.75-2.55 per 1000 live births, are closely comparable to data from the region, such as findings from Saudi Arabia and Iran, which reached 2.19 and 2.4, respectively. 3,[18][19][20][21][22][23][24] In the Kingdom of Saudi Arabia, the prevalence rate ranged from 0.3 to 2.4 per 1000 live births. 3,[18][19][20][21] In Oman, 10 health institutes and national registry data were retrospectively reviewed, and the prevalence was found to be 1.5 per 1000 live births.…”

Section: Discussionmentioning

confidence: 99%

“…Previously published evidence from Kuwait, based on the data from a single center study, reported a mean birth prevalence with a wide range of 0.57-1.56 per 1000 live birth. 3,4 Although genetic, epigenetic, and environmental factors have been investigated, welldesigned studies in Kuwait are minimal.…”

Section: Introductionmentioning

confidence: 99%

Seasonal, Geographic, and Ethnic Influence on the Prevalence of Orofacial Clefts in Kuwait: A Nationwide Study

Alkharafi

Mokhtar

Burezq

et al. 2023

The Cleft Palate Craniofacial Journal

View full text Add to dashboard Cite

Objective Accurate nationwide epidemiological evidence is vital to study the seasonal, geographic, and ethnic influence on the trends of orofacial cleft prevalence in Kuwait. Design Data obtained from the National Center for Health Information and Ministry of Health Hospital digital records were reviewed retrospectively to identify patients with orofacial clefts (OFC) using the ICD-10 diagnostic codes. The Jonckheere-Terpstra test was used to assess the trend of birth prevalence across the different years. The associations of types of OFC with ethnic and geographic influences were tested with chi-square or Fisher's exact tests, while the strength of that association was tested with multi-nominal logistic regression. Results Birth prevalence in Kuwait ranged from 0.75–2.55 per 1000 live births (0.73- 2.73 among Kuwaitis, 0.60–3.27 among non-Kuwaitis), with no statistically significant change observed during the past 28 years. The risk of unilateral cleft lip and palate was eight times higher during summer compared to Autumn, while the risk of cleft lip and palate remained lower during winter. Jahra (OR-7.76, CI- 1.51–39.80), Farwaneya (OR-6.65, CI- 1.34–33.06), and Hawalli (OR-6.72, CI- 1.26–35.98) governorates had higher odds of bilateral cleft lip when compared to Mubarak Alkabeer. Conclusions The study outcome is an indicator to improve patient care and customize healthcare infrastructure in the Ministry of Health. It also provides insight to develop projections of future needs. Future studies should focus on understanding the factors that might be a potential contributor to the seasonal change observed in the prevalence of OFC.

show abstract

“…Other studies found at birth prevalence of CAs was 41.2/1000 live births [6] and 23/1000 live births. [7]. Gastrointestinal malformations were 1.3 per 1000 live births, and neural tube defects were 1.9 per 1000 live births [8,9].…”

Section: Introductionmentioning

confidence: 99%

Examining the Prevalence of Congenital Anomalies in Newborns: A Cross-Sectional Study at a Tertiary Care Maternity Hospital in Saudi Arabia

Narapureddy,

Zahrani,

Alqahtani

et al. 2024

Children

View full text Add to dashboard Cite

Background: Congenital anomalies, representing structural or functional abnormalities present at birth, pose a substantial global health challenge, affecting 8 million newborns annually. With 3.3 million succumbing before age five and 3.2 million facing physical or mental disability, their diverse causes necessitate comprehensive understanding for effective healthcare planning. This study explores the prevalence of congenital anomalies among newborns in the Abha Maternity and Children Hospital (MCH) in Abha, Kingdom of Saudi Arabia. Methodology: A descriptive cross-sectional record-based study was conducted on newborns born between 2018 and 2022. Data were gathered in 4 months from September to December 2023. Purposive sampling was employed to select the case records of newborns with congenital anomalies after careful screening and considering inclusion and exclusion criteria. Data was acquired through a self-designed study tool, and the data were entered into Google Forms. Results: Congenital anomalies’ five-year prevalence was 3.21%, and one year, in 2022, the prevalence was 4.02%. Female neonates exhibited higher anomalies (59.3%), and preterm births accounted for 39.6%, emphasizing their vulnerability. The findings indicate that consanguineous marriages are linked to 63.3% of anomalies, notably neural tube defects (25%) and congenital heart diseases (19.7%). Anomalies are not significantly associated with consanguinity or birth order, but maternal age, education, employment, and antenatal maternal medical issues are associated considerably. Conclusions: These study insights contribute to health planners planning targeted interventions and awareness programs that are crucial to mitigate risks associated with preterm births and consanguineous marriages. The promotion of 100% antenatal screening and prophylactic medication for high-risk women and couples is necessary to prevent inherited deformities. In future the Ministry of Health must plan large-group prospective research to better understand the associated risk factors that will help public health initiatives minimize congenital-associated neonatal mortality and improve pregnancy outcomes.

show abstract

A Preliminary Report on Cleft Deformities of the Face and associated Anomalies in Abha, Saudi Arabia

Cited by 6 publications

References 19 publications

A cross-sectional study of cardiac anomalies among children with orofacial cleft - role of echocardiography

A cross-sectional study of cardiac anomalies among children with orofacial cleft - role of echocardiography

Seasonal, Geographic, and Ethnic Influence on the Prevalence of Orofacial Clefts in Kuwait: A Nationwide Study

Examining the Prevalence of Congenital Anomalies in Newborns: A Cross-Sectional Study at a Tertiary Care Maternity Hospital in Saudi Arabia

Contact Info

Product

Resources

About