A preliminary report of breast cancer screening by positron emission mammography

Yamamoto, Yayoi; Tasaki, Youichiro; Kuwada, Yukiko; Ozawa, Yukihiko; Inoue, Tomio

doi:10.1007/s12149-015-1040-0

Cited by 35 publications

(15 citation statements)

References 26 publications

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“…Also, PET/MRI has already been shown useful in whole-body staging of patients with invasive ductal breast carcinoma and recurrent breast cancer (11,14,32). The potential for highly accurate characterization of breast lesions using PET techniques has been demonstrated by Yamamoto et al (16). In a screening setting with 265 women, those authors were able to show that abnormal 18 F-FDG uptake (detected with PEM) showed a sensitivity of 100% and a specificity of 84.5%.…”

Section: Discussionmentioning

confidence: 97%

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Feasibility of ¹⁸F-FDG Dose Reductions in Breast Cancer PET/MRI

et al. 2018

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The goal of this study was to determine the level of clinically acceptable F-FDG dose reduction in time-of-flight PET/MRI in patients with breast cancer. Twenty-six consecutive women with histologically proven breast cancer were analyzed (median age, 51 y; range, 34-83 y). Simulated dose-reduced PET images were generated by unlisting the list-mode data on PET/MRI. The acquired 20-min PET frame was reconstructed in 5 ways: a reconstruction of the first 2 min with 3 iterations and 28 subsets for reference, and reconstructions simulating 100%, 20%, 10%, and 5% of the original dose. General image quality and artifacts, image sharpness, image noise, and lesion detectability were analyzed using a 4-point scale. Qualitative parameters were compared using the nonparametric Friedman test for multiple samples and the Wilcoxon signed-rank test for paired samples. Different groups of independent samples were compared using the Mann-Whitney test. Overall, 355 lesions (71 lesions with 5 different reconstructions each) were evaluated. The 20-min reconstruction with 100% injected dose showed the best results in all categories. For general image quality and artifacts, image sharpness, and noise, the reconstructions with a simulated dose of 20% and 10% were significantly better than the 2-min reconstructions ( ≤ 0.001). Furthermore, 20%, 10%, and 5% reconstructions did not yield results different from those of the 2-min reconstruction for detectability of the primary lesion. For 10% of the injected dose, a calculated mean dose of 22.6 ± 5.5 MBq (range, 17.9-36.9 MBq) would have been applied, resulting in an estimated whole-body radiation burden of 0.5 ± 0.1 mSv (range, 0.4-0.7 mSv). Ten percent of the standard dose ofF-FDG (reduction of ≤90%) results in clinically acceptable PET image quality in time-of-flight PET/MRI. The calculated radiation exposure would be comparable to the effective dose of a single digital mammogram. A reduction of radiation burden to this level might justify partial-body examinations with PET/MRI for dedicated indications.

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Section: Discussionmentioning

confidence: 97%

“…Nonetheless, like every imaging modality, MRI has its technically inherent limitations. Alternatively, PEM has already been proven to be helpful in characterizing small breast lesions (16). However, PEM scanners are specialized systems that cannot be used for a broader range of imaging, and they are not widely available yet.…”

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confidence: 99%

Feasibility of ¹⁸F-FDG Dose Reductions in Breast Cancer PET/MRI

et al. 2018

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“…With an improved resolution of PEM, some research showed that the detection rate of PEM was 2.3%, which is better than that of PET/CT (Yamamoto et al 2015(Yamamoto et al , 2016. Other research suggested that the sensitivity of PEM is significantly better than that of PET in tumors that are 20 mm or smaller in size (Eo et al 2012).…”

Section: Discussionmentioning

confidence: 99%

Newly-Developed Positron Emission Mammography (PEM) Device for the Detection of Small Breast Cancer

Yanai

Itoh

Higuchi

et al. 2018

Tohoku J. Exp. Med.

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Positron emission mammography (PEM) has higher detection sensitivity for breast cancer compared with whole-body positron emission tomography (PET) due to higher spatial resolution. We have developed a new PEM device with high resolution over a wide field of view. This PEM device comprises novel scintillation crystals, praseodymium-doped lutetium aluminum garnet (Pr:LuAG). In the present study, the clinical use of the newly developed PEM for the detection of small breast cancer was compared with that of the conventional PET-computed tomography (PET/CT). Eighty-two patients with breast cancer less than 20 mm (UICC T1) participated in this study, including 23 patients with T1a or T1b breast cancer (less than 10 mm). Histologically-proved lesions were examined by PET/CT and PEM on the same day after injection of [F]fluoro-2-deoxy-2-fluoro-D-glucose ([F]FDG), a marker of glycolytic activity. The newly developed PEM showed better sensitivity of cancer detection compared with PET/CT especially in case of the small T1a or T1b lesions. Moreover, when the conventional PET/CT and new PEM were combined, the detection sensitivity with [F]FDG molecular imaging for T1 (N = 82) and T1a plus T1b breast cancer (N = 23) were 90% and 70%, respectively. The uptake of [F]FDG was proportional to the histological malignancy of breast cancer. Using the newly-developed PEM with [F]FDG, we are able to identify and characterize exactly the small breast tumors less than 10 mm in combination with the conventional PET/CT. These data indicate that PEM and PET/CT are synergic and complementary for the detection of small breast cancer.

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“…SPECT radiation dose is about 1.1 mSv less than PEM. Furthermore, PEM is an expensive method as its cost is approximately 3.7 times higher than SPECT [40].…”

Section: Nuclear Medicine Imagingmentioning

confidence: 99%

A review of various modalities in breast imaging: technical aspects and clinical outcomes

Iranmakani

Mortezazadeh

Sajadian

et al. 2020

Egypt J Radiol Nucl Med

119

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Background: Nowadays, breast cancer is the second cause of death after cardiovascular diseases. In general, about one out of eight women (about 12%) suffer from this disease during their life in the USA and European countries. If breast cancer is detected at an early stage, its survival rate will be very high. Several methods have been introduced to diagnose breast cancer with their clinical advantages and disadvantages. Main text: In this review, various methods of breast imaging have been introduced. Furthermore, the sensitivity and specificity of each of these methods have been investigated. For each of the imaging methods, articles that were relevant to the past 10 years were selected through electronic search engines, and then the most relevant papers were selected. Finally, about 40 articles were studied and their results were categorized and presented in the form of a report as follows. Various breast cancer imaging techniques were extracted as follows: mammography, contrast-enhanced mammography, digital tomosynthesis, sonography, sonoelastography, magnetic resonance imaging, magnetic elastography, diffusion-weighted imaging, magnetic spectroscopy, nuclear medicine, optical imaging, and microwave imaging. Conclusion: The choice of these methods depends on the patient's state and stage, the age of the individual and the density of the breast tissue. Hybrid imaging techniques appear to be an acceptable way to improve detection of breast cancer. This review article can be useful in choosing the right method for imaging in people suspected of breast cancer.

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A preliminary report of breast cancer screening by positron emission mammography

Abstract: PEM screening appears to have potential for breast cancer screening.

Cited by 35 publications

References 26 publications

Feasibility of ¹⁸F-FDG Dose Reductions in Breast Cancer PET/MRI

Feasibility of ¹⁸F-FDG Dose Reductions in Breast Cancer PET/MRI

Newly-Developed Positron Emission Mammography (PEM) Device for the Detection of Small Breast Cancer

A review of various modalities in breast imaging: technical aspects and clinical outcomes

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A preliminary report of breast cancer screening by positron emission mammography

Abstract: PEM screening appears to have potential for breast cancer screening.

Cited by 35 publications

References 26 publications

Feasibility of 18F-FDG Dose Reductions in Breast Cancer PET/MRI

Feasibility of 18F-FDG Dose Reductions in Breast Cancer PET/MRI

Newly-Developed Positron Emission Mammography (PEM) Device for the Detection of Small Breast Cancer

A review of various modalities in breast imaging: technical aspects and clinical outcomes

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Product

Resources

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Feasibility of ¹⁸F-FDG Dose Reductions in Breast Cancer PET/MRI

Feasibility of ¹⁸F-FDG Dose Reductions in Breast Cancer PET/MRI