A preliminary report: effects of zinc and micronutrient repletion on growth and neuropsychological function of urban Chinese children.

Penland, James G.; Sandstead, Harold H.; Alcock, Nancy W.; Dayal, Hari H.; Chen, X C; Li, J S; Zhao, Faji; Jia, Yang

doi:10.1080/07315724.1997.10718684

Cited by 86 publications

(56 citation statements)

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“…More sensitive techniques such as knee-height measurements might have helped detect any subtle improvement (Himes et al, 1991). Certainly, Penland et al, (1997) reported a significant increase in knee-height after only 10 weeks, in Chinese children aged 6 -9 y of age receiving a daily supplement containing 20 mg Zn plus micronutrients compared to those receiving a daily supplement of 20 mg Zn alone. In rural Malawi where the prevalence of stunting among rural adults is high (Gibson & Huddle, 1998), any growth response is likely to be constrained by a combination of intrauterine growth retardation and inter-generational effects of malnutrition.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of a multi-micronutrient dietary intervention based on haemoglobin, hair zinc concentrations, and selected functional outcomes in rural Malawian children

et al. 2002

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Objective: To investigate the efficacy of enhancing the content and bioavailability of micronutrients in diets of stunted rural Malawian children on their growth and body composition, morbidity, anaemia and hair zinc concentrations. Design: A quasi-experimental design with non-equivalent control group involving 410 intervention and 220 control children aged 30 -90 months. Setting and subjects: Children from two intervention and two control villages in Mangochi District, Southern Malawi participated in a 6 month dietary intervention. Anthropometry, malarial screening, haemoglobin, and hair zinc were measured at baseline and after 12 months, as well as socio-economic status at baseline, and common infections monthly postintervention. Results: Groups were comparable at baseline. Post-intervention children had greater Z-scores for lean body mass (mid-upper arm circumference 70.75 vs 71.05; arm muscle area: 0.63 vs 71.03, P < 0.001) than controls but Z-scores for weight-forheight and height-for-age were similar. After controlling for baseline variables, mean haemoglobin was higher (107 vs 102 g=l, P < 0.01), whereas the incidence of both anaemia (62 vs 80%) and common infections (based on a median overall illness score for fever, diarrhoea, upper and lower respiratory infections) were lower in intervention compared to controls, with no change in hair zinc concentrations or malaria status post-intervention. Conclusion: Improvements in the micronutrient adequacy of diets of post-intervention children were associated with a favourable increase in indices of lean body mass and reductions in the incidence of anaemia and common infections in these rural Malawian stunted children.

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Section: Discussionmentioning

confidence: 99%

Efficacy of a multi-micronutrient dietary intervention based on haemoglobin, hair zinc concentrations, and selected functional outcomes in rural Malawian children

et al. 2002

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“…The mean duration of supplementation was 90 d (Cavan et al, 1993). In contrast, in China, neurocognitive function was better in children aged 6±9 y supplemented with zinc for 10 weeks, or zinc with other micronutrients, compared with children with micronutrients alone (Penland et al, 1997). In one study of very low birth weight infants in Newfoundland, Canada, psychomotor development in the ®rst year of life was examined and was found to improve with 3 months' zinc supplementation (Friel et al, 1993).…”

Section: Discussionmentioning

confidence: 99%

Zinc supplementation, mental development and behaviour in low birth weight term infants in northeast Brazil

et al. 1998

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“…There is a large body of convincing evidence linking zinc deficiency to childhood growth stunting, 32 increased prevalence of common childhood infections such as diarrhea and pneumonia, 33 reduced appetite among children, 34 impaired neurobehavioral function, 35,36 delayed sexual maturation among adolescents, 37 poor pregnancy outcomes including low birth weight, preterm deliveries, maternal delivery complications, 38 and impaired immune function of the neonate, 39 and increased risk of infant mortality among low birth weight infants. 40 Despite these far reaching consequences, much remains to be learned about efficacious methods to prevent zinc deficiency.…”

Section: Zinc Nutritional Statusmentioning

confidence: 99%

Iron, zinc and iodide status in Mexican children under 12 years and women 12-49 years of age: a probabilistic national survey

et al. 2003

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Objective. To describe the epidemiology of iron, zinc and iodide deficiencies in a probabilistic sample of Mexican women and children and explore its association with some dietary and socio-demographic variables. Material and Methods. We carried out in 1999 an epidemiological description of iron (percent transferrin saturation, PTS, <16%), serum zinc (<65ug/dl) and iodide (<50 ug/l urine) deficiencies in a probabilistic sample of 1,363 Mexican children under 12 years and of 731 women of child-bearing age. Serum iron, Total Iron Binding Capacity (TIBC) and zinc were measured by atomic absorption spectrometry, and urinary iodide by a colorimetric method. Logistic regression models explored determinants for such micromineral deficiencies. Results. Iron deficiency was higher (67%) in infants <2 years of age. Prevalence declined (34-39%) at school age. The prevalence for iron deficiency in women was 40%. Zinc deficiency was higher in infants <2 years of age (34%) than in school-age children (19-24%). Prevalence in women was 30%, with no rural/urban difference. In women the likelihood of iron deficiency decreased as SEL improved (p=0.04) and increased with the intake of cereals (p=0.01). The likelihood of low serum zinc levels was greater in women and children of low socioeconomic level (SEL) (p<0.02 and p=0.001) iodide deficiency was negligible in both children and women. Conclusions. The data shows high prevalence of iron deficiencyspecially in infants 12 to 24 months of age. It is suggested that

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A preliminary report: effects of zinc and micronutrient repletion on growth and neuropsychological function of urban Chinese children.

Cited by 86 publications

References 1 publication

Efficacy of a multi-micronutrient dietary intervention based on haemoglobin, hair zinc concentrations, and selected functional outcomes in rural Malawian children

Efficacy of a multi-micronutrient dietary intervention based on haemoglobin, hair zinc concentrations, and selected functional outcomes in rural Malawian children

Zinc supplementation, mental development and behaviour in low birth weight term infants in northeast Brazil

Iron, zinc and iodide status in Mexican children under 12 years and women 12-49 years of age: a probabilistic national survey

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