A preliminary randomised controlled study of short-term Antrodia cinnamomea treatment combined with chemotherapy for patients with advanced cancer

Tsai, Ming-Yen; Hung, Yu‐Chiang; Chen, Yen‐Hao; Chen, Yung‐Hsiang; Huang, Yu‐Chuen; Kao, Chao-Wei; Su, Yu‐Li; Chiu, Hsienhsueh Elley; Rau, Kun‐Ming

doi:10.1186/s12906-016-1312-9

Cited by 34 publications

(42 citation statements)

References 37 publications

(40 reference statements)

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“…A large variety of cancer entities, studied sample sizes, outcomes, treatment durations and observation times were seen ( Table 1). The medicinal mushrooms investigated were Agaricus sylvaticus (two trials) (Fortes et al, 2008;Costa Fortes et al, 2010;Costa Fortes and Carvalho Garbi Novaes, 2011;Valadares et al, 2013), Agaricus blazei murill (two trials) (Ahn et al, 2004;Tangen et al, 2015), Antrodia cinnamomea (one trial) (Tsai et al, 2016), Coriolus versicolor (one trial) (Chay et al, 2017) and Ganoderma lucidum (three trials) (Gao et al, 2003a;Oka et al, 2010;Zhao et al, 2012). All mushrooms were administered orally.…”

Section: Resultsmentioning

confidence: 99%

Significance of Medicinal Mushrooms in Integrative Oncology: A Narrative Review

et al. 2020

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Medicinal mushrooms are widely used in East Asia for the treatment of various diseases, especially in complementary cancer care. While there is a growing interest in medicinal mushrooms in Western countries and an increasing number of pre-clinical studies indicate distinct anti-cancer and regenerative properties, little is known about their potential relevance for clinical practice. This review aims to provide an overview of the clinical evidence, significance and potential role of medicinal mushrooms in complementary cancer care. Scientific databases for (randomized) controlled clinical trials evaluating whole spectrum formulations of medicinal mushrooms (mushroom powder and mushroom extracts) in cancer patients during and/or after conventional oncological treatment were searched. Eight studies met our inclusion criteria (eight randomized controlled trials, one controlled clinical trial). The medicinal mushrooms investigated were Agaricus sylvaticus (two trials), Agaricus blazei murill (two trials), Antrodia cinnamomea (one trial), Coriolus versicolor (one trial) and Ganoderma lucidum (three trials); all were compared to placebo and administered orally. A variety of cancer entities, outcomes and treatment durations were observed. Study results suggested beneficial effects of medicinal mushrooms, particularly quality of life and reduction of adverse effects of conventional therapies. Also, positive effects on antitumor activity and immunomodulation were reported, e.g., an increased activity of natural killer cells. In addition, results might suggest a longer survival of cancer patients receiving mushroom preparations, although in most studies this was not significant when compared to placebo. Adverse events of treatment with medicinal mushrooms were poorly reported; gastrointestinal reactions and a decrease in platelet cell count occurred in some cases. The methodological quality of most studies was generally unsatisfying and most results were insufficiently reported in several respects. Medicinal mushrooms may have a therapeutic potential for cancer patients during and after conventional oncological care with regards to quality of life, reduction of adverse effects of conventional care and possibly other surrogate parameters like immune function. There is an urgent need to investigate the safety and possible interactions of medicinal mushrooms. High-quality clinical research is warranted in order to clarify the potential of medicinal mushrooms in cancer therapy.

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Section: Resultsmentioning

confidence: 99%

Significance of Medicinal Mushrooms in Integrative Oncology: A Narrative Review

et al. 2020

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“…Several investigations have already shown the synergistic effects of EEA combined with cisplatin (16), sorafenib (12), and tamoxifen (13). The antitumor effect of EEA has been confirmed in a randomized controlled study, although the synergistic effects of EEA combined with chemotherapy were not observed (26). It has been proposed that cancer stem-like cells were involved in tumor initiation and occurrence of chemoradiotherapy resistance, responsible for compromised clinical outcomes of conventional therapies (2,27,28).…”

Section: Discussionmentioning

confidence: 95%

Effect of ethanol extracts of Antrodia cinnamomea on head and neck squamous cell carcinoma cell line

Liu

Wang

2020

Braz J Med Biol Res

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Head and neck squamous cell carcinoma (HNSCC) is one of the most common malignant tumors. Ethanol extract of Antrodia cinnamomea (EEA) has been widely studied for its health benefits including anticancer effects. The purpose of this study was to assess the effects of EEA on HNSCC. Cell proliferation, transwell, and wound healing assays were performed. The impact of EEA on tumor growth was investigated using a xenograft model. Expressions of migration-related proteins (MMP-2, MMP-9, TIMP-1, and TIMP-2) and apoptosis-related proteins (cleaved caspase-9 and cleaved PARP) were determined using western blot analysis. The results indicated that EEA significantly inhibited the capacities of proliferation, invasion, and migration of HNSCC cells in a dose-dependent manner. Cleaved caspase-9 and cleaved PARP expressions were increased in cells treated with an increasing concentration of EEA, which suggested that EEA induced apoptosis of HNSCC. MMP-2 and MMP-9 were downregulated when cells were administered EEA, while TIMP-1 and TIMP-2 were not affected, which uncovered the mechanisms mediating the EEAinduced inhibition on cell invasion and migration. The animal experiment also suggested that EEA inhibited tumor growth. Our study confirmed the inhibitive effects of EEA on cell proliferation, invasion, and migration of HNSCC in vitro and in vivo, providing the basis for further study of the application of EEA as an effective candidate for cancer treatment.

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“…After taking AC for three months, there was no significant change in liver and renal function indices, blood pressure, triglyceride, and fasting blood glucose levels [ 7 ]. AC has been used in the complementary treatment of cancers, with some clinical test results reported, including colorectal cancer [ 8 ], adenocarcinomas [ 9 ], and lung cancer [ 6 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Antrodia cinnamomea Extraction Waste Supplementation Promotes Thermal Stress Tolerance and Tissue Regeneration Ability of Zebrafish

Chang

Wang

et al. 2020

Molecules

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Antrodia cinnamomea (AC) has been shown to have anti-inflammatory, anti-tumor, and immunomodulation activities. It is estimated that hundreds of metric tons of AC extraction waste (ACEW) are produced per year in Taiwan. This study aims to assess the feasibility of applying ACEW as feed supplement in the aquaculture industry. ACEW significantly inhibited the growth of microorganisms in the water tank, by around 39.4% reduction on the fifth day with feed supplemented of 10% ACEW. The feed conversion efficiency of zebrafish with 10% ACEW supplementation for 30 days was 1.22-fold compared to that of the control. ACEW dramatically improved the tolerances of zebrafish under the heat and cold stresses. When at water temperature extremes of 38 °C or 11 °C, compared to the 100% mortality rate in the control group, the 10% ACEW diet group still had 91.7% and 83.3% survival rates, respectively. In a caudal fin amputation test, the fin recovery of zebrafish was increased from 68.4% to 93% with 10% ACEW diet after 3-week regeneration. ACEW effectively down-regulated the gene expression of TNF-α, IL-1β, IL-6, and IL-10, and up-regulated the gene expression of IL-4/13A. Additionally, the supplement of ACEW in the feed can maintain and prevent the fish’s body weight from dropping too much under enteritis. Taken together, ACEW has beneficial potential in aquaculture.

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A preliminary randomised controlled study of short-term Antrodia cinnamomea treatment combined with chemotherapy for patients with advanced cancer

Cited by 34 publications

References 37 publications

Significance of Medicinal Mushrooms in Integrative Oncology: A Narrative Review

Significance of Medicinal Mushrooms in Integrative Oncology: A Narrative Review

Effect of ethanol extracts of Antrodia cinnamomea on head and neck squamous cell carcinoma cell line

Antrodia cinnamomea Extraction Waste Supplementation Promotes Thermal Stress Tolerance and Tissue Regeneration Ability of Zebrafish

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