A preliminary magnetic resonance imaging study of ECT-treated depressed patients

Pande, Atul C.; Grunhaus, Leon; Aisen, Alex M.; Haskett, Roger F.

doi:10.1016/0006-3223(90)90025-w

Cited by 23 publications

(7 citation statements)

References 8 publications

(5 reference statements)

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“…Complications (tachycardia, ECT-changes) were significantly more often noted in patients with concomitant cardiological disorders before ECT-treatment. No changes were detected on CT or MRI pre-to post-treatment Pande et al, 1990). Information on mortality figures after ECTtreatment is sometimes conflicting, some studies reporting lower or comparable mortality rates in ECT-treated patients (Babigian and Guttmacher, 1994;Philibert et al, 1995;O'Leary and Lee, 1996), others reporting higher mortality figures than non-ECT treated patients (Kroessler and Fogel, 1993).…”

Section: B Non-randomised Studiesmentioning

confidence: 93%

The efficacy and safety of ECT in depressed older adults: a literature review

Wurff

Stek

Hoogendijk

et al. 2003

Int J Geriat Psychiatry

117

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Section: B Non-randomised Studiesmentioning

confidence: 93%

The efficacy and safety of ECT in depressed older adults: a literature review

Wurff

Stek

Hoogendijk

et al. 2003

Int J Geriat Psychiatry

117

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“…Hindered by poor resolution (typical slice thickness 5–12 mm, inter slice interval 1–2.5 mm), low field strength (0.08, 1 or 1.5 T), and limited tools for quantification or automated image processing, these studies were primarily focused on disproving the hypothesis that ECT causes brain damage. Structural changes or gross evidence of harmful effects was not found ( Coffey et al, 1988 , Figiel et al, 1989 , Pande et al, 1990 , Puri et al, 1998 ). However, ECT-induced changes in tissue parameters, such as an increase in T1- and T2 relaxation times ( Mander et al, 1987 , Scott et al, 1990 ) were reported.…”

Section: Introductionmentioning

confidence: 99%

The Global ECT-MRI Research Collaboration (GEMRIC): Establishing a multi-site investigation of the neural mechanisms underlying response to electroconvulsive therapy

Oltedal

Bartsch

Sørhaug

et al. 2017

NeuroImage: Clinical

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Major depression, currently the world's primary cause of disability, leads to profound personal suffering and increased risk of suicide. Unfortunately, the success of antidepressant treatment varies amongst individuals and can take weeks to months in those who respond. Electroconvulsive therapy (ECT), generally prescribed for the most severely depressed and when standard treatments fail, produces a more rapid response and remains the most effective intervention for severe depression. Exploring the neurobiological effects of ECT is thus an ideal approach to better understand the mechanisms of successful therapeutic response. Though several recent neuroimaging studies show structural and functional changes associated with ECT, not all brain changes associate with clinical outcome. Larger studies that can address individual differences in clinical and treatment parameters may better target biological factors relating to or predictive of ECT-related therapeutic response. We have thus formed the Global ECT-MRI Research Collaboration (GEMRIC) that aims to combine longitudinal neuroimaging as well as clinical, behavioral and other physiological data across multiple independent sites. Here, we summarize the ECT sample characteristics from currently participating sites, and the common data-repository and standardized image analysis pipeline developed for this initiative. This includes data harmonization across sites and MRI platforms, and a method for obtaining unbiased estimates of structural change based on longitudinal measurements with serial MRI scans. The optimized analysis pipeline, together with the large and heterogeneous combined GEMRIC dataset, will provide new opportunities to elucidate the mechanisms of ECT response and the factors mediating and predictive of clinical outcomes, which may ultimately lead to more effective personalized treatment approaches.

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“…[10][11][12][13][14] Coffey et al, 15 comparing magnetic resonance imaging results of 35 subjects pretreatment to imaging done 2 to 3 days and 6 months after a series, found no acute volumetric changes. [10][11][12][13][14] Coffey et al, 15 comparing magnetic resonance imaging results of 35 subjects pretreatment to imaging done 2 to 3 days and 6 months after a series, found no acute volumetric changes.…”

Section: Discussionmentioning

confidence: 99%

Neuropathological Evaluation of an 84-Year-Old Man After 422 ECT Treatments

Anderson¹,

Wollmann

Dinwiddie

2014

The Journal of ECT

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Concern remains among many that electroconvulsive therapy (ECT) causes "brain damage." This ambiguous term presumably refers to lesions that could, in principle, be observed either grossly or microscopically in postmortem studies, and the assertion that it occurs appears to be based largely on old reports with dubious relevance to modern practice. Fortunately, using modern technique, ECT is so safe that mortality around the time of treatment is extraordinarily rare and as a result there has been little opportunity for postmortem examination of individuals who had recently had ECT. We report a case in which postmortem brain examination was performed roughly a month after the patient's last treatment.

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A preliminary magnetic resonance imaging study of ECT-treated depressed patients

Cited by 23 publications

References 8 publications

The efficacy and safety of ECT in depressed older adults: a literature review

The efficacy and safety of ECT in depressed older adults: a literature review

The Global ECT-MRI Research Collaboration (GEMRIC): Establishing a multi-site investigation of the neural mechanisms underlying response to electroconvulsive therapy

Neuropathological Evaluation of an 84-Year-Old Man After 422 ECT Treatments

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