A preliminary investigation on the relationship between gut microbiota and gene expressions in peripheral mononuclear cells of infants with autism spectrum disorders

Inoüe, Ryo; Sakaue, Yuko; Sawai, Chihiro; Sawai, Toshihiro; Ozeki, Motoyuki; Romero-Pérez, Gustavo A.; Tsukahara, Takamitsu

doi:10.1080/09168451.2016.1222267

Cited by 110 publications

(120 citation statements)

References 66 publications

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“…No functional gastrointestinal disorders (FGID) were reported in five articles (De Angelis et al ., ; Inoue et al ., ; Shaaban et al ., ; Berding and Donovan, ; Coretti et al ., ). Although there is a greater prevalence of GI symptoms in ASD (McElhanon et al ., ; Martínez‐González and Andreo‐Martínez, ) there are studies reporting no FGID, as some authors excluded children with ASD and FGID in their studies (De Angelis et al ., ; Strati et al ., ; Berding and Donovan, ).…”

Section: Sample Characteristics and Other Parameters Studiedmentioning

confidence: 99%

“…Phylogenetic map of bacterial populations (Phyla, families, genera and species level) in ASD. Note: [A = Williams et al ., ; B = Gondalia et al ., ; C = Kang et al ., ; D = Wang et al ., ; E = De Angelis et al ., ; F = Son et al ., ; G = Tomova et al ., ; H = Inoue et al ., ; I = Strati et al ., ; J = Iovene et al ., ; K= Luna et al ., ; L = Finegold et al ., ; M = Kushak et al ., ; N = Shaaban et al ., ; O = Gora et al ., ; P = Kang et al ., ; Q = Pulikkan et al ., ; R = Rose et al ., ; S = Coretti et al ., ; T = Zhang et al ., ; U = Berding and Donovan, ]. …”

Section: Dysbiosis Of the Gm In Asdmentioning

confidence: 99%

“…Specifically, children with ASD eating 20 foods or less in their diet had lower intakes of pectin, vitamin C, niacin, vitamin B6, folate and selenium but higher intakes of added sugars (Berding and Donovan, ). Streptococcus was found to be less abundant in duodenal biopsy samples from the second part of the duodenum of American children with ASD compared to their HC group (Kushak et al ., ), in faeces of Chinese (Zhang et al ., ) and Japanese (Inoue et al ., ) children with ASD compared to their HC groups, respectively, and in faeces of Italian children with ASD compared to their HC (Coretti et al ., ) and siblings (De Angelis et al ., ) groups, respectively, with Streptococcus and Enterococcus being the dominant genera of the Bacilli class in the work of De Angelis et al . ().…”

Section: Higher or Lower Abundance Of Gut Microbes In Asdmentioning

confidence: 99%

“…At family level: Rikenellaceae (Berding and Donovan, 2018), Actinomycetaceae, Streptococcaceae and Gemellaceae (Coretti et al, 2018). At genus level: Fusobacterium, Eubacterium, Subdoligranulum, Enterococcus, Turicibacter, presumptive Staphylococcus, presumptive Streptococcus and Lactococcus, and presumptive Enterococcus and Lactobacillus (De Angelis et al, 2013), Alistipes (Strati et al, 2017), Dialister and Bilophila (Strati et al, 2017;Berding and Donovan, 2018), Eggerthella (Coretti et al, 2018), Peptoniphilus, Parvimonas, Bulleida and Escherichia (Zhang et al, 2018), Haemophilus (Kang et al, 2018), Neisseria (Kushak et al, 2017), Coprococcus (Kang et al, 2013;Coretti et al, 2018), Veillonella (Strati et al, 2017;Zhang et al, 2018), Prevotella (De Angelis et al, 2013Kang et al, 2013;Kushak et al, 2017), Streptococcus (De Angelis et al, 2013Inoue et al, 2016;Kushak et al, 2017;Coretti et al, 2018;Zhang et al, 2018), Butyricimonas and Butyrivibrio (Berding and Donovan, 2018), and Devosia (Kushak et al, 2017). At species level: Bacteroides vulgatus, unidentified Bacteroides and Escherichia coli (Kushak et al, 2017), Prevotella copri and Haemophilus parainfluenzae (Kang et al, 2018).…”

Section: High Abundance Of Some Gut Microbes In Asdmentioning

confidence: 99%

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An approach to gut microbiota profile in children with autism spectrum disorder

Andreo-Martínez

García-Martínez

Sánchez-Samper

et al. 2019

Environ Microbiol Rep

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Summary In recent years, there has been an increase in studies on the implications of gut microbiota (GM) on the behaviour of children with autism spectrum disorders (ASD) due to a dysbiosis in GM that can trigger onset, development or progression of ASD through the microbiota–gut–brain axis. The aim of this study is to carry out a systematic review of articles from the last 6 years that analyse GM in children with ASD compared to GM in control groups. Children with ASD showed a higher abundance of Roseburia and Candida genera, and lower abundance of Dialister, Bilophila, Veillonella, Streptococcus, Coprococcus and Prevotella genera. Those differences can be attributed to factors such as different nationalities, nature of control groups, place where the sample was taken, gastrointestinal (GI) problems or bacterial detection methods. It is still too early to define a specific GM profile of children with ASD, and future studies should focus on homogenizing the characteristics of samples and control groups. Furthermore, new multicentre studies should also focus on the impact of GM on GI physiology, neurophysiology and behaviour of children with ASD, and on performing psychometric analyses of the correlation between the severity of ASD behavioural symptoms and GM profiles.

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Section: Sample Characteristics and Other Parameters Studiedmentioning

confidence: 99%

Section: Dysbiosis Of the Gm In Asdmentioning

confidence: 99%

Section: Higher or Lower Abundance Of Gut Microbes In Asdmentioning

confidence: 99%

Section: High Abundance Of Some Gut Microbes In Asdmentioning

confidence: 99%

See 2 more Smart Citations

An approach to gut microbiota profile in children with autism spectrum disorder

Andreo-Martínez

García-Martínez

Sánchez-Samper

et al. 2019

Environ Microbiol Rep

View full text Add to dashboard Cite

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“…16S rRNA sequencing using the MiSeq TM system (Illumina, San Diego, CA, USA) was performed according to a previously described method [23]. Briefly, the V3-V4 hypervariable regions of 16S rRNA were PCR-amplified using the universal primers 341F and 805R [24].…”

Section: S Rrna Sequencingmentioning

confidence: 99%

Analysis of endoscopic brush samples identified mucosa-associated dysbiosis in inflammatory bowel disease

et al. 2017

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Background The mucosa-associated gut microbiota directly modulates epithelial and mucosal function. In this study, we investigated the mucosa-associated microbial community in patients with inflammatory bowel disease (IBD), using endoscopic brush samples. Methods A total of 174 mucus samples from 43 patients with ulcerative colitis (UC), 26 with Crohn's disease (CD) and 14 non-IBD controls were obtained by gentle brushing of mucosal surfaces using endoscopic cytology brushes. The gut microbiome was analyzed using 16S rRNA gene sequencing. Results There were no significant differences in microbial structure among different anatomical sites (the ileum, cecum and sigmoid colon) within individuals. There was, however, a significant difference in microbial structure between CD, UC and non-IBD controls. The difference between CD and non-IBD controls was more marked than that between UC patients and non-IBD controls. a-Diversity was significantly lower in UC and CD patients than non-IBD controls. When comparing CD patients with non-IBD controls, the phylum Proteobacteria was significantly increased and the phyla Firmicutes and Bacteroidetes were significantly reduced. These included a significant increase in the genera Escherichia, Ruminococcus (R. gnavus), Cetobacterium, Actinobacillus and Enterococcus, and a significant decrease in the genera Faecalibacterium, Coprococcus, Prevotella and Roseburia. Comparisons between CD and UC patients revealed a greater abundance of the genera Escherichia, Ruminococcus (R. gnavus), Clostridium, Cetobacterium, Peptostreptococcus in CD patients, and the genera Faecalibacterium, Blautia, Bifidobacterium, Roseburia and Citrobacter in UC patients. Conclusions Mucosa-associated dysbiosis was identified in IBD patients. CD and UC may be distinguishable from the mucosa-associated microbial community structure.

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Alteration of the fecal microbiota in Chinese children with autism spectrum disorder

Xie

et al. 2022

Autism Research

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Autism spectrum disorder (ASD) is associated with altered gut microbiota. However, there has been little consensus on the altered bacterial species and studies have had small sample sizes. We aimed to identify the taxonomic composition and evaluate the changes in the fecal microbiota in Chinese children with ASD by using a relatively large sample size. We conducted a case–control study of 101 children with ASD and 103 healthy controls in China. Demographic information and fecal samples were collected, and the V3‐V4 hypervariable regions of the bacterial 16S ribosomal RNA (rRNA) gene were sequenced. The alpha and beta diversities between the two groups were significantly different. After correcting for multiple comparisons, at the phylum level the relative abundances of Actinobacteria and Proteobacteria in the case group were significantly higher than those in the control group. The relative abundance of the Escherichia‐Shigella genus in the case group was significantly higher than that of the control group, and the relative abundance of Blautia and unclassified_f__Lachnospiraceae in the control group were higher than that of the case group. Phylogenetic Investigation of Communities by Reconstruction of Unobserved States analysis showed that children with ASD may have disturbed functional pathways, such as amino acid metabolism, cofactor and vitamin metabolism, and the AMP‐activated protein kinase signaling pathway. This study revealed the characteristics of the intestinal flora of Chinese children with ASD and provided further evidence of gut microbial dysbiosis in ASD. Lay Summary This study characterized the gut microbiota composition of 101 children with ASD and 103 healthy controls in China. The altered gut microbiota may contribute significantly to the risk of ASD, including significant increases in the relative abundances of Actinobacteria, Proteobacteria and Escherichia‐Shigella and significant decrease of Blautia and unclassified_f__Lachnospiraceae. This study provided further evidence of gut microbial dysbiosis in ASD.

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A preliminary investigation on the relationship between gut microbiota and gene expressions in peripheral mononuclear cells of infants with autism spectrum disorders

Cited by 110 publications

References 66 publications

An approach to gut microbiota profile in children with autism spectrum disorder

An approach to gut microbiota profile in children with autism spectrum disorder

Analysis of endoscopic brush samples identified mucosa-associated dysbiosis in inflammatory bowel disease

Alteration of the fecal microbiota in Chinese children with autism spectrum disorder

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