A preliminary investigation on the effect of extracorporeal shock wave therapy as a treatment for neurogenic heterotopic ossification following traumatic brain injury. Part I: Effects on pain

Reznik, Jacqueline; Biroš, Erik; Sacher, Yaron; Kibrik, O.; Milanese, Steve; Gordon, Susan; Galea, Mary P.

doi:10.1080/02699052.2017.1283059

Cited by 14 publications

(7 citation statements)

References 27 publications

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“…Treatment options for primary or recurrent HO are sparse 13 , and medical therapies for HO are essentially limited to non-steroidal anti-inflammatory drugs and low-dose radiation 11 . Pain precedes HO in sporadic forms 14 – 16 , and even rare genetic forms 17 – 19 , which is often out of proportion to clinical examination. Given these clinical observations, we hypothesized that sensory innervation would play a pathoetiogenic role in trauma-induced HO.…”

Section: Introductionmentioning

confidence: 99%

NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma

et al. 2021

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Pain is a central feature of soft tissue trauma, which under certain contexts, results in aberrant osteochondral differentiation of tissue-specific stem cells. Here, the role of sensory nerve fibers in this abnormal cell fate decision is investigated using a severe extremity injury model in mice. Soft tissue trauma results in NGF (Nerve growth factor) expression, particularly within perivascular cell types. Consequently, NGF-responsive axonal invasion occurs which precedes osteocartilaginous differentiation. Surgical denervation impedes axonal ingrowth, with significant delays in cartilage and bone formation. Likewise, either deletion of Ngf or two complementary methods to inhibit its receptor TrkA (Tropomyosin receptor kinase A) lead to similar delays in axonal invasion and osteochondral differentiation. Mechanistically, single-cell sequencing suggests a shift from TGFβ to FGF signaling activation among pre-chondrogenic cells after denervation. Finally, analysis of human pathologic specimens and databases confirms the relevance of NGF-TrkA signaling in human disease. In sum, NGF-mediated TrkA-expressing axonal ingrowth drives abnormal osteochondral differentiation after soft tissue trauma. NGF-TrkA signaling inhibition may have dual therapeutic use in soft tissue trauma, both as an analgesic and negative regulator of aberrant stem cell differentiation.

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Section: Introductionmentioning

confidence: 99%

NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma

et al. 2021

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“…Single-dose radiotherapy or oral nonsteroidal anti- inflammatory drugs such as indometacin and maintaining joint ROM post-stroke are used as HO prophylaxis and treatment. [ 17 ] Preliminary studies and case reports on the role of extracorporeal shock wave therapy (ESWT) in the treatment of neurogenic HO following traumatic brain injury and spinal cord injury suggest that ESWT may reduce pain and increase ROM of the affected joints;[ 18 - 20 ] however, excisional surgery remains the treatment of choice to restore joint mobility. [ 6 , 21 ] In this case, the contracture of the osteoarthritic left knee may have developed secondary to the neurogenic HO of the hips, as this results in reduced mobility and poor positioning of the patient within bed.…”

Section: Discussionmentioning

confidence: 99%

Post-stroke bilateral heterotopic ossification: An acute problem with long-lasting consequences

2020

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“…A elevação do metabolismo local, provocada pela aplicação das ondas de choque, favorece um aumento da circulação, aumentando a ação de agentes lipolíticos liberados pela indução inflamatória gerada pela ação da TOC. O próprio aumento metabólico favorece um maior consumo energético de modo que se verifica um consumo maior das moléculas de gordura armazenadas na zona de aplicação 14,15 .…”

Section: Discussionunclassified

Efeitos das ondas de choque piezoelétrica na adiposidade localizada

Silva

Borges²,

Silva³

et al. 2019

Cons. Saúde

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Introdução: A terapia de ondas de choque piezoelétrica (TOC) é uma técnica não invasiva que visa a reduzir o tecido adiposo subcutâneo localizado. Objetivos: Investigar os efeitos da terapia ondas de choque piezoelétrica na redução da adiposidade subcutânea localizada. Métodos: Efetuou-se um estudo experimental, com 31 participantes, de 25 a 45 anos, do sexo feminino. Foram realizadas quatro sessões de tratamento, uma vez por semana com parâmetros da OC piezoelétrica. Procedeu-se à aplicação dinâmica na região infraumbilical; e estacionária, na supraumbilical, ambas no lado esquerdo. O lado direito não recebeu aplicação, tornando-se o lado controle. Resultados: Na aplicação da TOC piezoelétrica na forma estacionária, houve maior redução de tecido adiposo do que no modo dinâmico. Conclusão: Pode-se observar que a terapia por OC piezoelétrica promoveu uma redução da adiposidade localizada, com o modelo de equipamento escolhido e na dose proposta neste estudo, constatada nas análises de plicometria e ultrassonografia.

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A preliminary investigation on the effect of extracorporeal shock wave therapy as a treatment for neurogenic heterotopic ossification following traumatic brain injury. Part I: Effects on pain

Cited by 14 publications

References 27 publications

NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma

NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma

Post-stroke bilateral heterotopic ossification: An acute problem with long-lasting consequences

Efeitos das ondas de choque piezoelétrica na adiposidade localizada

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