A preliminary investigation of the impact of catechol-O-methyltransferase genotype on the absorption and metabolism of green tea catechins

Miller, Rosalind J.; Jackson, Kim G.; Dadd, Tony; Nicol, Beate; Dick, Joanne L.; Mayes, Andrew E.; Brown, Angela L.; Minihane, Anne Marie

doi:10.1007/s00394-011-0189-0

Cited by 26 publications

(18 citation statements)

References 49 publications

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“…These are in line with intervention trials that report similar inconsistent results regarding the presence of metabolites in urine and plasma [18], [19]. Miller et al [20] examined the effect of COMT genotype on absorption and metabolism of catechins and concluded that different polymorphisms seem to have no large impact. In contrast, Choi et al [21] demonstrated in 660 daily GT drinking subjects that subjects with the low-activity COMT genotype excreted less catechin metabolites via their urine compared with subjects that carried the high-activity genotype.…”

Section: Discussionsupporting

confidence: 68%

“…In contrast, Choi et al [21] demonstrated in 660 daily GT drinking subjects that subjects with the low-activity COMT genotype excreted less catechin metabolites via their urine compared with subjects that carried the high-activity genotype. The absence of an effect in the study of Miller et al [20] was attributed to the low availability of catechins. This was explained by the existence of two different COMT proteins; cytoplasm soluble protein (S-COMT) and membrane bound protein (MB-COMT).…”

Section: Discussionmentioning

confidence: 84%

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The Role of Catechol-O-Methyl Transferase Val(108/158)Met Polymorphism (rs4680) in the Effect of Green Tea on Resting Energy Expenditure and Fat Oxidation: A Pilot Study

et al. 2014

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IntroductionGreen tea(GT) is able to increase energy expenditure(EE) and fat oxidation(FATox) via inhibition of catechol-O-methyl transferase(COMT) by catechins. However, this does not always appear unanimously because of large inter-individual variability. This may be explained by different alleles of the functional COMT Val108/158Met polymorphism that are associated with COMT enzyme activity; high-activity enzyme, COMTH(Val/Val genotype), and low-activity COMTL(Met/Met genotype).MethodsFourteen Caucasian subjects (BMI: 22.2±2.3 kg/m2, age: 21.4±2.2 years) of whom 7 with the COMTH-genotype and 7 with the COMTL-genotype were included in a randomized, cross-over study in which EE and substrate oxidation were measured with a ventilated-hood system after decaffeinated GT and placebo(PL) consumption.ResultsAt baseline, EE, RQ, FATox and carbohydrate oxidation(CHOox) did not differ between groups. Significant interactions were observed between COMT genotypes and treatment for RQ, FATox and CHOox (p<0.05). After GT vs. PL, EE(GT: 62.2 vs. PL: 35.4 kJ.3.5 hrs; p<0.01), RQ(GT: 0.80 vs. PL: 0.83; p<0.01), FATox(GT: 18.3 vs. PL: 15.3 g/d; p<0.001) and CHOox(GT: 18.5 vs. PL: 24.3 g/d; p<0.001) were significantly different for subjects carrying the COMTH genotype, but not for subjects carrying the COMTL genotype (EE, GT: 60.3 vs. PL: 51.7 kJ.3.5 hrs; NS), (RQ, GT: 0.81 vs. PL: 0.81; NS), (FATox, GT: 17.3 vs. PL: 17.0 g/d; NS), (CHOox, GT: 22.1 vs. PL: 21.4 g/d; NS).ConclusionSubjects carrying the COMTH genotype increased energy expenditure and fat-oxidation upon ingestion of green tea catechins vs, placebo, whereas COMTL genotype carriers reacted similarly to GT and PL ingestion. The differences in responses were due to the different responses on PL ingestion, but similar responses to GT ingestion, pointing to different mechanisms. The different alleles of the functional COMT Val108/158Met polymorphism appear to play a role in the inter-individual variability for EE and FATox after GT treatment.Trial RegistrationNederlands Trial register NTR1918

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Section: Discussionsupporting

confidence: 68%

Section: Discussionmentioning

confidence: 84%

The Role of Catechol-O-Methyl Transferase Val(108/158)Met Polymorphism (rs4680) in the Effect of Green Tea on Resting Energy Expenditure and Fat Oxidation: A Pilot Study

et al. 2014

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“…However, other compounds including plasma metabolites of tea polyphenols, such as methylated compounds/phase I-breakdown or gut microbial metabolites (in addition to glucuronidated and sulphated substances), could also be involved. Although EGCG can be methylated 30 , very low 31 , or no methylated (or otherwise metabolised) EGCG 32 was found in human plasma after consumption of a green tea extract or green tea. An inverse association between the degree of urinary flavonoid O-methylation (4OMGA) and FMD after consumption of black tea indicates that methylation of tea flavonoids could rather affect endothelial function 33 .…”

Section: Discussionmentioning

confidence: 99%

Tea-induced improvement of endothelial function in humans: No role for epigallocatechin gallate (EGCG)

Lorenz

Rauhut

Hofer

et al. 2017

Sci Rep

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Consumption of tea is inversely associated with cardiovascular diseases. However, the active compound(s) responsible for the protective effects of tea are unknown. Although many favorable cardiovascular effects in vitro are mediated by epigallocatechin gallate (EGCG), its contribution to the beneficial effects of tea in vivo remains unresolved. In a randomised crossover study, a single dose of 200 mg EGCG was applied in three different formulas (as green tea beverage, green tea extract (GTE), and isolated EGCG) to 50 healthy men. Flow-mediated dilation (FMD) and endothelial-independent nitro-mediated dilation (NMD) was measured before and two hours after ingestion. Plasma levels of tea compounds were determined after each intervention and correlated with FMD. FMD significantly improved after consumption of green tea containing 200 mg EGCG (p < 0.01). However, GTE and EGCG had no significant effect on FMD. NMD did not significantly differ between interventions. EGCG plasma levels were highest after administration of EGCG and lowest after consumption of green tea. Plasma levels of caffeine increased after green tea consumption. The results show that EGCG is most likely not involved in improvement of flow-mediated dilation by green tea. Instead, other tea compounds, metabolites or combinations thereof may play a role.

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“…It is produced by brewing dried leaves and buds of Camelia sinensis. Green tea consumption has been proposed to have a great variety of beneficial health effects including neuroprotective, anti-carcinogenic, anti-obesogenic, antiatherosclerotic, hypolipidemic, anti-diabetic, antiinflammatory, anti-bacterial, and antiviral [75][76][77]. However, little epidemiological data are available regarding green tea consumption and cognitive function.…”

Section: Green Tea Polyphenols and Secondary Prevention Of Alzhemier mentioning

confidence: 99%

“…A normal brewed cup of green tea with 2.5 g of tea leaves may contain between 130 and 180 mg of EGCG [74]. Besides being the most abundant green tea catechin, EGCG has gathered a lot of attention and is considered the most bioactive tea compound [76].…”

Section: Green Tea Polyphenols and Secondary Prevention Of Alzhemier mentioning

confidence: 99%

Potential Role of (-)-Epigallocatechin-3-Gallate (EGCG) in the Secondary Prevention of Alzheimer Disease

Xicota¹,

Rodríguez-Morató²,

Dierssen³

et al. 2016

CDT

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Medical advances in the last decades have increased the average life expectancy, but also the incidence and prevalence of age-associated neurodegenerative diseases. Alzheimer's disease (AD) is one of the most common neurodegenerative diseases and the most prevalent type of dementia. A plethora of different mechanisms contribute to AD, among which oxidative stress plays a key role in its development and progression. So far, there are no pharmacological treatments available and the current medications are mainly symptomatic. In the last years, dietary polyphenols have gained research attention due to their interesting biological activities, and more specifically their antioxidant properties. (-)- Epigallocatechin-3-gallate (EGCG) is a natural flavanol that has been extensively studied regarding its potential effects in AD. In this review we present the current in vitro and in vivo experimentation regarding the use of EGCG in AD. We also review the complex mechanisms of action of EGCG, not only limited to its antioxidant activity, which may explain its beneficial health effects.

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A preliminary investigation of the impact of catechol-O-methyltransferase genotype on the absorption and metabolism of green tea catechins

Abstract: In conclusion, the COMT Val(158/108)Met does not appear to have a dramatic influence on EGCG absorption and elimination. However, further pharmacokinetic research is needed to substantiate these findings.

Cited by 26 publications

References 49 publications

The Role of Catechol-O-Methyl Transferase Val(108/158)Met Polymorphism (rs4680) in the Effect of Green Tea on Resting Energy Expenditure and Fat Oxidation: A Pilot Study

The Role of Catechol-O-Methyl Transferase Val(108/158)Met Polymorphism (rs4680) in the Effect of Green Tea on Resting Energy Expenditure and Fat Oxidation: A Pilot Study

Tea-induced improvement of endothelial function in humans: No role for epigallocatechin gallate (EGCG)

Potential Role of (-)-Epigallocatechin-3-Gallate (EGCG) in the Secondary Prevention of Alzheimer Disease

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