A preliminary investigation of chlorinated hydrocarbons and chronic fatigue syndrome

Rh, Dunstan; Donohoe, Mark; Taylor, Warren G.; Tk, Roberts; Murdoch, R. N.; Ja, Watkins; McGregor, Neil

doi:10.5694/j.1326-5377.1995.tb124593.x

Cited by 19 publications

(3 citation statements)

References 15 publications

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“…Studies have been conducted to monitor the levels of toxins in the blood of patients with CFS with a view to determine whether they have any influence of the pathogenesis of disease. Dunstan et al (1995) have shown that the levels of organophosphates in the blood of CFS patients were higher than in control subjects and comparable to that of CFS patients with known chemical exposure. It has been shown that ciguatera fish toxin poisoning can lead to CFS and that immunological and HPA axis abnormalities are observed in these patients at higher frequency than patients suffering from CFS following EBV infection (Racciatti et al, 2001).…”

Section: Toxin Exposurementioning

confidence: 69%

Chronic fatigue syndrome

Devanur

Kerr

2006

Journal of Clinical Virology

131

105

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Section: Toxin Exposurementioning

confidence: 69%

Chronic fatigue syndrome

Devanur

Kerr

2006

Journal of Clinical Virology

131

105

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“…Workers exposed to HCB showed an impaired lytic activity of neutrophils in the presence of Candida albicans and Candida pseudotropicalis (60). It is noteworthy that NK cells seem to have a role in the pathogenesis of chronic fatigue syndrome (CFS) (61) and that patients with CFS showed elevated HCB serum levels (62). The incidence of HCB contamination (> 2.0 ppb) was 45% in a CFS group compared with 21% in a non-CFS control group (p < 0.05) (62).…”

Section: Discussionmentioning

confidence: 99%

Associations of Blood Levels of PCB, HCHs, and HCB with Numbers of Lymphocyte Subpopulations, in Vitro Lymphocyte Response, Plasma Cytokine Levels, and Immunoglobulin Autoantibodies

Daniel¹,

Huber²,

Bauer³

et al. 2001

Environmental Health Perspectives

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“…One study found that patients with unexplained, persistent fatigue had higher levels of DDE (1,1-dichloro-2,2-bis (p-chlorophenyl) ethane-an organochlorine) compared with controls [60]. A study of chlorinated hydrocarbon levels in patients with chronic fatigue syndrome concluded that organochlorines may indeed be involved in the aetiology of ME/CFS [61], and it could be that this involvement of such environmental chemicals is in combination with genetic factors [62]. There have been reports of an outbreak of ME/CFS in Nevada at the same time as an increased incidence of non-Hodgkin's lymphoma [63,64].…”

Section: Occupational Exposuresmentioning

confidence: 99%

The Role of Prevention in Reducing the Economic Impact of ME/CFS in Europe: A Report from the Socioeconomics Working Group of the European Network on ME/CFS (EUROMENE)

et al. 2021

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This report addresses the extent to which there may be scope for preventive programmes for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), and, if so, what economic benefits may accrue from the implementation of such programmes. We consider the economic case for prevention programmes, whether there is scope for preventive programmes for ME/CFS, and what are the health and economic benefits to be derived from the implementation of such programmes. We conclude that there is little scope for primary prevention programmes, given that ME/CFS is attributable to a combination of host and environmental risk factors, with host factors appearing to be most prominent, and that there are few identified modifiable risk factors that could be the focus of such programmes. The exception is in the use of agricultural chemicals, particularly organophosphates, where there is scope for intervention, and where Europe-wide programmes of health education to encourage safe use would be beneficial. There is a need for more research on risk factors for ME/CFS to establish a basis for the development of primary prevention programmes, particularly in respect of occupational risk factors. Secondary prevention offers the greatest scope for intervention, to minimise diagnostic delays associated with prolonged illness, increased severity, and increased costs.

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A preliminary investigation of chlorinated hydrocarbons and chronic fatigue syndrome

Cited by 19 publications

References 15 publications

Chronic fatigue syndrome

Chronic fatigue syndrome

Associations of Blood Levels of PCB, HCHs, and HCB with Numbers of Lymphocyte Subpopulations, in Vitro Lymphocyte Response, Plasma Cytokine Levels, and Immunoglobulin Autoantibodies

The Role of Prevention in Reducing the Economic Impact of ME/CFS in Europe: A Report from the Socioeconomics Working Group of the European Network on ME/CFS (EUROMENE)

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