A preliminary evaluation of a positron camera system using weighted decoding of individual crystals

Holte, S.; Eriksson, Lars; Larsson, Jan; Ericson, Tove; Stjernberg, H.; Hansen, P.; Bohm, C.; Kesselberg, M.; Rota, E.; Herzog, Hans; Feinendegen, L. E.

doi:10.1109/23.12821

Cited by 23 publications

(6 citation statements)

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“…With the subsequent transition of PET imaging to primarily 18 F-FDG oncology studies, the benefit of TOF PET with these early scintillators could not help overcome the reduced sensitivity and worse spatial resolution. Hence, the 1990s saw PET system design dominated by Non-TOF scanners primarily using BGO crystals with septa for 2D data acquisition [12,13], or alternately using large NaI(Tl) crystals without septa for fully-3D data acquisition [14,15]. …”

Section: Brief History Of Tof Petmentioning

confidence: 99%

Advances in time-of-flight PET

2016

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This paper provides a review and an update on time-of-flight PET imaging with a focus on PET instrumentation, ranging from hardware design to software algorithms. We first present a short introduction to PET, followed by a description of TOF PET imaging and its history from the early days. Next, we introduce the current state-of-art in TOF PET technology and briefly summarize the benefits of TOF PET imaging. This is followed by a discussion of the various technological advancements in hardware (scintillators, photo-sensors, electronics) and software (image reconstruction) that have led to the current widespread use of TOF PET technology, and future developments that have the potential for further improvements in the TOF imaging performance. We conclude with a discussion of some new research areas that have opened up in PET imaging as a result of having good system timing resolution, ranging from new algorithms for attenuation correction, through efficient system calibration techniques, to potential for new PET system designs.

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Section: Brief History Of Tof Petmentioning

confidence: 99%

Advances in time-of-flight PET

2016

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“…Attenuation correction is based on transmission scans for which a rotating line source is used. The number of registered random and scattered coincidences is drastically reduced by the use of the line source instead of a ring source, which is applied in many other PET scanners (Thompson et al 1986;Holte et al 1988). Due to the line source it is possible to perform transmission scans even after the injection of the radiopharmaceutical without major errors or the need for specific correction procedures (Carroll et al 1983;Carson et al 1988).…”

Section: Livermentioning

confidence: 99%

Quantification of the whole-body distribution of PET radiopharmaceuticals, applied to 3-N-([18F]fluoroethyl)spiperone

et al. 1990

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Using a multi slice whole body PET scanner PC4096-15WB, diagnostic measurements of the cerebral distribution of the D2 receptor ligand 3-N-([18F]fluoroethyl)spiperone were extended to quantify the biodistribution of this PET radiopharmaceutical. As a rotating line source was used for measured attenuation correction, transmission scans could be combined with emission scans even after injection of the tracer. Only 1% of the total administered dose (TAD) was found in the whole brain at 180 min, but the striatum and pituitary were still excellently delineated. Urinary bladder, gall bladder, and liver were the organs with the highest TAD ranging from 6% to 25%. The gall bladder is the critical organ with an absorbed dose of about 200 muGy/MBq followed by the urinary bladder and liver with 83 and 66 muGy/MBq, respectively. In the rest of the body radioactivity was evenly distributed. The total body dose was found to be 11.9 muGy/MBq.

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“…A technique suitable to identify signals from small crystals in PET is a modified form of the Anger technique (Anger, 1963;Burnham et al, 1985), called the blockdetector method (Murayama et al, 1982;Casey & Nutt, 1986;Eriksson et al, 1986;Dahlbom & Hoffman, 1988;Holte et al, 1988). Figure 6(a) shows an example of a detector block with four scintillators directly mounted on two PMT.…”

Section: Block-detector Conceptmentioning

confidence: 99%

“…A number of instruments, positron cameras or PET scanners, with different design parameters have been developed for this purpose. Some are designed to study the distribution of positron emitters in the brain (Cho et al, 1976;Bohm et al, 1978; Hoffman et al, 1982; Bergstrom, 1982;Litton et al, 1984; Kanno et al, 1985), while others are dedicated to other parts of the body (Phelps et al, 1975;Williams et al, 1979;Hoffman et al, 1983;Budinger et al, 1984;Holte et al, 1988). The data obtained are used to reconstruct images describing these distributions.…”

Section: Introductionmentioning

confidence: 99%

Positron emission tomography—a new technique for studies of the central nervous system

Eriksson

Dahlbom

Widén

1990

Journal of Microscopy

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KEY WORDS. Positron emission tomography, positron camera, central nervous system, brain imaging, brain studies. S U M M A R YPositron emission tomography (PET) has become an important tool to study the central nervous system. Examples of such studies are cerebral blood flow and metabolism and determination of receptor characteristics of the brain. In the following the basic principles and the physics behind PET are given. Different aspects are discussed such as detector design, image reconstructions and data analyses. Since quantification is essential in PET, data have to be corrected for absorption, scatter and random coincidences. These corrections and their influence on image data are discussed.A review of state-of-the-art PET research of the brain is given.

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A preliminary evaluation of a positron camera system using weighted decoding of individual crystals

Cited by 23 publications

References 0 publications

Advances in time-of-flight PET

Advances in time-of-flight PET

Quantification of the whole-body distribution of PET radiopharmaceuticals, applied to 3-N-([18F]fluoroethyl)spiperone

Positron emission tomography—a new technique for studies of the central nervous system

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