A Preliminary Clinical Experience Using Hypothermic Oxygenated Machine Perfusion for Rapid Recovery of Octogenarian Liver Grafts

Rayar, Michel; Maillot, Betty; Bergeat, Damien; Camus, Christophe; Houssel‐Debry, Pauline; Sulpice, Laurent; Meunier, Brigitte; Boudjéma, Karim

doi:10.1177/1526924818817072

Cited by 9 publications

(12 citation statements)

References 3 publications

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“…The protective effect of HMP was observed especially in grafts from DCD donors, whereas only 1 article showed a significant reduction of overall biliary complications in HMP-treated donation after brain death (DBD) donor grafts. (8) Of 13 articles (7,8,(10)(11)(12)(13)(14)(15)(16)(17)(18)21,22) reporting the incidence of biliary complications after HMP, 11 reported the incidence of ischemia-type biliary lesions (ITBLs) as well. (7,(10)(11)(12)(13)(14)(15)(16)(17)(18)21) Nine studies had a control group composed of SCS grafts.…”

Section: What Is the Impact Of Hmp Versus Scs In Terms Of Ischemia-tymentioning

confidence: 99%

“…(8) Of 13 articles (7,8,(10)(11)(12)(13)(14)(15)(16)(17)(18)21,22) reporting the incidence of biliary complications after HMP, 11 reported the incidence of ischemia-type biliary lesions (ITBLs) as well. (7,(10)(11)(12)(13)(14)(15)(16)(17)(18)21) Nine studies had a control group composed of SCS grafts. (8,(10)(11)(12)(13)(14)(15)(16)21) ITBL incidence ranged from 0% to 10% in HMP-treated grafts, and from 0% to 45% after SCS.…”

Section: What Is the Impact Of Hmp Versus Scs In Terms Of Ischemia-tymentioning

confidence: 99%

“…(7,(10)(11)(12)(13)(14)(15)(16)(17)(18)21) Nine studies had a control group composed of SCS grafts. (8,(10)(11)(12)(13)(14)(15)(16)21) ITBL incidence ranged from 0% to 10% in HMP-treated grafts, and from 0% to 45% after SCS. In the SCS group, ITBLs were more frequent in DCD grafts (22% versus 2%) as compared with DBD grafts.…”

Section: What Is the Impact Of Hmp Versus Scs In Terms Of Ischemia-tymentioning

confidence: 99%

“…Unfortunately, the lack of a common definition of biliary complications across studies and follow-up periods shorter than 12 months in most of the articles (7,11,13,14,17,18,21,23,24) limited the strength of the results.…”

Section: What Is the Impact Of Hmp Versus Scs In Terms Of Ischemia-tymentioning

confidence: 99%

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Machine Perfusions in Liver Transplantation: The Evidence‐Based Position Paper of the Italian Society of Organ and Tissue Transplantation

et al. 2020

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The use of machine perfusion (MP) in liver transplantation (LT) is spreading worldwide. However, its efficacy has not been demonstrated, and its proper clinical use has far to go to be widely implemented. The Società Italiana Trapianti d’Organo (SITO) promoted the development of an evidence‐based position paper. A 3‐step approach has been adopted to develop this position paper. First, SITO appointed a chair and a cochair who then assembled a working group with specific experience of MP in LT. The Guideline Development Group framed the clinical questions into a patient, intervention, control, and outcome (PICO) format, extracted and analyzed the available literature, ranked the quality of the evidence, and prepared and graded the recommendations. Recommendations were then discussed by all the members of the SITO and were voted on via the Delphi method by an institutional review board. Finally, they were evaluated and scored by a panel of external reviewers. All available literature was analyzed, and its quality was ranked. A total of 18 recommendations regarding the use and the efficacy of ex situ hypothermic and normothermic machine perfusion and sequential normothermic regional perfusion and ex situ MP were prepared and graded according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) method. A critical and scientific approach is required for the safe implementation of this new technology.

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Section: What Is the Impact Of Hmp Versus Scs In Terms Of Ischemia-tymentioning

confidence: 99%

Section: What Is the Impact Of Hmp Versus Scs In Terms Of Ischemia-tymentioning

confidence: 99%

Section: What Is the Impact Of Hmp Versus Scs In Terms Of Ischemia-tymentioning

confidence: 99%

Section: What Is the Impact Of Hmp Versus Scs In Terms Of Ischemia-tymentioning

confidence: 99%

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Machine Perfusions in Liver Transplantation: The Evidence‐Based Position Paper of the Italian Society of Organ and Tissue Transplantation

et al. 2020

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“…The safety and efficacy of HOPE have also been confirmed. Rayar et al [33] reported two cases of successful liver transplantation using HOPE to preserve ECD livers in their center. In one of the cases, the donor was over 80 years old, with steatosis greater more than 20% and cold ischemia time (CIT) greater than 10 hours.…”

Section: Hypothermic Machine Perfusion (Hmp)mentioning

confidence: 99%

Research progress on hepatic machine perfusion

Gao¹,

He²,

Xia³

et al. 2021

Int. J. Med. Sci.

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Nowadays, liver transplantation is the most effective treatment for end-stage liver disease. However, the increasing imbalance between growing demand for liver transplantation and the shortage of donor pool restricts the development of liver transplantation. How to expand the donor pool is a significant problem to be solved clinically. Many doctors have devoted themselves to marginal grafting, which introduces livers with barely passable quality but a high risk of transplant failure into the donor pool. However, existing common methods of preserving marginal grafts lead to both high risk of postoperative complications and high mortality. The application of machine perfusion allows surgeons to make marginal livers meet the standard criteria for transplant, which shows promising prospect in preserving and repairing donor livers and improving ischemia reperfusion injury. This review summarizes the progress of recent researches on hepatic machine perfusion.

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Chinese expert consensus on organ protection of transplantation (2022 edition)

Wang

et al. 2022

Hepatobiliary & Pancreatic Diseases International

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A Preliminary Clinical Experience Using Hypothermic Oxygenated Machine Perfusion for Rapid Recovery of Octogenarian Liver Grafts

Cited by 9 publications

References 3 publications

Machine Perfusions in Liver Transplantation: The Evidence‐Based Position Paper of the Italian Society of Organ and Tissue Transplantation

Machine Perfusions in Liver Transplantation: The Evidence‐Based Position Paper of the Italian Society of Organ and Tissue Transplantation

Research progress on hepatic machine perfusion

Chinese expert consensus on organ protection of transplantation (2022 edition)

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