Lateral saltwater intrusion (LSWI) and vertical saltwater intrusion (VSWI) are the major problems in coastal aquifers. Coastal aquifers are subjected to natural and artificial changes, including sea-level rise, decreasing inland recharge, and overexploitation of production wells' water resources. Therefore, this study investigates the influence of changing the coastal aquifers boundary conditions considering climate changes' effect. Parameters describing the upward saline well parameters based on the abstraction conditions, also, the top layer properties were studied based on the erosion and sediments, irrigation, and drainage conditions. For this purpose, the SEA-WAT model was employed to simulate lateral SWI based on Henry's problem principle. The sensitivity analysis of the mentioned parameters was accomplished considering as a case study the Biscayne aquifer in the Cutler Ridge area near Deering Estate, Florida, USA, where the LSWI and VSWI were also investigated. The results indicate that the boundary conditions, abstraction well parameters, and top layer cost significantly impact aquifer LSWI and water upconing. The simulation results of the Biscayne aquifer for a saline water head of 84.86 cm for 2060 indicate