A Pregnant Patient with Adrenocortical Carcinoma: Case Report

Abstract

Background: Coexistence of an adrenocortical carcinoma and pregnancy is extremely rare with only 25 described cases so far, and has a poor prognosis. Case Report: We report the case of a 28-year-old patient with adrenocortical carcinoma initially presenting with Cushing‘s syndrome and pre-eclampsia in the 22nd week of gestation, treated in our department. She underwent adrenalectomy, but eventually died from metastatic disease. We focus on existing treatment options and concerns for this rare malignancy during pregnancy. Conclusion: Early diagnosis and surgery are the cornerstones for better outcome.

Effect of mitotane on mouse ovarian follicle development and fertility

“…6B). The results of our experiments are in agreement with recent case reports (Kotteas et al 2012, Tripto-Shkolnik et al 2013 and with an extensive study that included 17 cases of pregnant women affected by ACC, recruited through the multicenter and international databases provided by the European Network for the Study of Adrenal Tumors (ENSAT) (de Corbiere et al 2015). Furthermore, in our mating experiments, we found no malformations or signs of adrenal insufficiency in the offspring of mice treated with MTT, in agreement with the findings of the clinical ENSAT retrospective study (de Corbiere et al 2015).…”

“…Open issues to be addressed are related to impaired primordial follicle reserve and damage to the steroidogenesis machinery in the ovary. Data on this topic are very scarce, except for a few case reports regarding pregnancy in patients with ACC treated with MTT (Kotteas et al 2012, Tripto-Shkolnik et al 2013.…”

Cushing’s syndrome diagnosed after delivery: a case report

“…If an adrenocortical carcinoma is the cause of Cushing's syndrome, fetal prognosis is no different than in cases when Cushing's syndrome is due to an adrenocortical adenoma [34,35]. Early treatment improves prognosis, and its delay could be deleterious [36].…”