A Pregnane Derivative and an Anti-plasmodial Labdane Diterpenoid from the Stem Bark of <i>Turraenthus Africanus</i>

Akam, Thomas M.; Tane, Pierre; Wabo, Hippolyte K.; Yong, Joseph N.; Fanso-Free, Samual N. Y.; Connolly, Joseph D.; Evans, Cameron; Farrugia, Louis J.

doi:10.1177/1934578x0600100603

Cited by 6 publications

(5 citation statements)

References 14 publications

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“… 15 In the last few years, WHO has recommended withdrawal of the oral artemisinin-based monotherapies from the market due to the risk of emergence of artemisinin-resistant parasites; 14 , 16 therefore, several new researches have been conducted to find new natural sources of antimalarial drugs. 17 - 21 Based on these investigations, remarkable diversity of new natural products such as coumarin derivatives, 22 , 23 flavonoides, 24 , 25 stilbenes, 26 - 28 sesquiterpenes, 29 , 30 diterpenes, 31 , 32 steroids, 33 alkaloids, 34 - 37 etc. showed antiplasmodial activities in different in vitro assays.…”

Section: Introductionmentioning

confidence: 99%

In vitro antimalarial activity of different extracts of Eremostachys macrophylla Montbr. & Auch.

et al. 2017

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Introduction:The risk of drug resistance and the use of medicinal plants in malaria prevention and treatment have led to the search for new antimalarial compounds with natural origin. Methods:In the current study, six extracts with different polarity from aerial parts and rhizomes of Eremostachys macrophylla Montbr. & Auch., were screened for their antimalarial properties by cell-free β-hematin formation assay. Results: Dichloromethane (DCM) extracts of both parts of plant showed significant antimalarial activities with IC50 values of 0.797 ± 0.016 mg/mL in aerial parts and 0.324 ± 0.039 mg/mL in rhizomes compared to positive control (Chloroquine, IC50 = 0.014 ± 0.003 mg/mL, IC90 = 0.163 ± 0.004 mg/mL). Bioactivity-guided fractionation of the most potent part (DCM extract of rhizomes) by vacuum liquid chromatography (VLC) afforded seven fractions. Sixty percent ethyl acetate/n-hexane fraction showed considerable antimalarial activity with IC50 value of 0.047 ± 0.0003 mg/mL. Conclusion: From 6 extracts with different polarity of E. macrophylla,s aerial parts and rhizomes, the DCM extract of both parts were the most active extract in this assay. The preliminary phytochemical study on the VLC fractions of the most potent part persuades us to focus on purifying the active components of these extracts and to conduct further investigation towards in vivo evaluation.

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Section: Introductionmentioning

confidence: 99%

In vitro antimalarial activity of different extracts of Eremostachys macrophylla Montbr. & Auch.

et al. 2017

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“…Table 3 gives the tested terpenoid compounds presenting low or no activity in vitro against various strains of P. falciparum. 41,58,65,74,78,80,87,89,92,94,105,110,115,117–119,121–140 …”

Section: Introductionmentioning

confidence: 99%

Antimalarial compounds isolated from plants used in traditional medicine

Béro

Frédérich

Quetin-Leclercq

2009

Journal of Pharmacy and Pharmacology

155

100

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“…Table 3 gives the tested terpenoid compounds presenting low or no activity in vitro against various strains of P. falciparum. [41,58,65,74,78,80,87,89,92,94,105,110,115,[117][118][119][121][122][123][124][125][126][127][128][129][130][131][132][133][134][135][136][137][138][139][140] and 0.24 mM, respectively, on NF54, and 1.43, 1.73, 1.88, 1.72 and 1.79, respectively, on ENT30. Four of these alkaloids were further evaluated intraperitoneally for activity against P. berghei in vivo.…”

Section: Diterpenesmentioning

confidence: 97%

Antimalarial compounds isolated from plants used in traditional medicine

2009

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Objectives This review covers the compounds with antiplasmodial activity isolated from plants published from 2005 to the end of 2008, organized according to their phytochemical classes. Details are given for substances with IC50 values 11 mM. Key findings Malaria is a major parasitic disease in many tropical and subtropical regions and is responsible for more than 1 million deaths each year in Africa. The rapid spread of resistance encourages the search for new active compounds. Nature and particularly plants used in traditional medicine are a potential source of new antimalarial drugs as they contain molecules with a great variety of structures and pharmacological activities. Summary A large number of antimalarial compounds with a wide variety of structures have been isolated from plants and can play a role in the development of new antimalarial drugs. Ethnopharmacological approaches appear to be a promising way to find plant metabolites that could be used as templates for designing new derivatives with improved properties.

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A Pregnane Derivative and an Anti-plasmodial Labdane Diterpenoid from the Stem Bark of Turraenthus Africanus

Cited by 6 publications

References 14 publications

In vitro antimalarial activity of different extracts of Eremostachys macrophylla Montbr. & Auch.

In vitro antimalarial activity of different extracts of Eremostachys macrophylla Montbr. & Auch.

Antimalarial compounds isolated from plants used in traditional medicine

Antimalarial compounds isolated from plants used in traditional medicine

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