A predictive value of quantitative HBsAg for serum HBV DNA level among HBeAg-positive pregnant women

Sun, Kun; Li, Jie; Zhu, Fengcai; Liu, Jianxun; Li, Rongcheng; Zhai, Xiangjun; Li, Yanping; Chang, Zhan-Jun; Nie, Jun; Zhang, Hui

doi:10.1016/j.vaccine.2012.06.036

Cited by 61 publications

(80 citation statements)

References 37 publications

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“…1). It is similar to the study reported by Sun et al (2012) who reported serum HBV DNA levels in pregnant women. This may attribute to changes of HBV DNA load during the natural course of chronic infection.…”

Section: Discussionsupporting

confidence: 92%

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Can hepatitis B virus DNA in semen be predicted by serum levels of hepatitis B virus DNA, HBeAg, and HBsAg in chronically infected men from infertile couples?

Fei

Yang

et al. 2015

Andrology

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SUMMARYHepatitis B virus (HBV) in semen is important for father-to-child transmission of HBV and has adverse effects on sperm quality. However, risk factors associated with HBV in semen remain unclear. Serum HBV DNA and hepatitis B e antigen (HBeAg) levels may pose a risk on HBV in semen. This study aims to examine whether serum HBV DNA, HBeAg, and hepatitis B surface antigen (HBsAg) level were associated with HBV DNA in semen. 151 male patients chronically infected with HBV from infertile couples were included. Serum HBsAg and HBeAg were determined using an electrochemiluminescence immune assay (ECLIA). Serum and seminal plasma HBV DNA were detected by the QIAGEN Real-Time HBV DNA assay. Of 151 patients, 143 (94.7%) were serum HBV DNA-positive and 65 (43.0%) were seminal plasma HBV DNA-positive. Serum HBV DNA and HBeAg level of seminal plasma HBV DNA-positive patients were significantly higher (p < 0.001) as compared with those of seminal plasma HBV DNA-negative patients, HBsAg level of seminal plasma HBV DNA-positive patients was significantly lower (p < 0.001) compared with that of seminal plasma HBV DNA-negative patients. The best serum HBV DNA, HBeAg, and HBsAg value for discriminating between seminal plasma HBV DNA-positive and HBV DNA-negative patients were ≥6.9 log 10 IU/mL (sensitivity 100.0%, specificity 90.7%), >14.8 S/CO (sensitivity 96.9%, specificity 81.5%), and <1791.5 S/CO (sensitivity 81.5%, specificity 81.2%), respectively. The combination of serum HBV DNA and HBeAg had high diagnostic sensitivity (100.0%) and specificity (95.4%) for the presence of HBV DNA in semen. As such, these serum markers especially the combination of HBV DNA and HBeAg are useful predictors of the presence of HBV DNA in semen in HBV chronically infected men from infertile couples.

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Section: Discussionsupporting

confidence: 92%

“…Previous studies had demonstrated that serum HBsAg level could be used as a predictive marker of serum HBV DNA for patients infected with HBV (Su et al, 2010;Sun et al, 2012). As expected, our data show that serum HBV DNA, HBeAg, and HBsAg level could discriminate seminal HBV DNA-positive patients from seminal HBV DNA-negative patients.…”

Section: Discussionsupporting

confidence: 87%

Can hepatitis B virus DNA in semen be predicted by serum levels of hepatitis B virus DNA, HBeAg, and HBsAg in chronically infected men from infertile couples?

Fei

Yang

et al. 2015

Andrology

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show abstract

“…[198][199][200][201] NA prophylaxis could be also useful in the few HBeAg-negative women with high levels of viremia but normal ALT levels. [198][199][200][201] These mothers should be informed that utilising a NA to reduce their viremia levels increase the effectiveness to HBIG and vaccination. LAM, TBV or TDF prophylaxis has been used in this setting during the last trimester of pregnancy.…”

Section: Pregnancy Recommendationsmentioning

confidence: 99%

EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection

Lampertico¹,

Agarwal²,

Berg³

et al. 2017

Journal of Hepatology

4,013

3,081

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“…In a serological survey in China in 2006, HBsAg carrier status was around 7.18% (Liang et al, 2009). In Taiwan, the HBsAg carrier status was found to range from 10 to 20%, whiles in Taipei it was about 5% among infants increasing to 10% by the second birthday (Sun et al, 2012).…”

Section: Preventive Measuresmentioning

confidence: 99%

“…The vertical transmission is influenced by several factors such as maternal levels of HBV-DNA, HBeAg, variations in gene S of hepatitis B virus (HBV), duration of labor, and neonatal immune deficiency (Raniers et al;Shen et al, 2008;Singh et al, 2011;Sun et al, 2012). Gestational age during hepatitis B infection is an important factor affecting infant outcome (Chang, 2007).…”

Section: Transmission Mechanismsmentioning

confidence: 99%

Maternal-child health

Groß¹,

Wydra²

2013

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A predictive value of quantitative HBsAg for serum HBV DNA level among HBeAg-positive pregnant women

Cited by 61 publications

References 37 publications

Can hepatitis B virus DNA in semen be predicted by serum levels of hepatitis B virus DNA, HBeAg, and HBsAg in chronically infected men from infertile couples?

Can hepatitis B virus DNA in semen be predicted by serum levels of hepatitis B virus DNA, HBeAg, and HBsAg in chronically infected men from infertile couples?

EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection

Maternal-child health

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