2023
DOI: 10.1098/rspa.2023.0323
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A predictive model of UV-A-riboflavin crosslinking treatment on porcine corneas

Alessandra Bonfanti,
Anna Pandolfi

Abstract: The crosslinking technique (CXL) is an effective low-risk therapeutic treatment of keratoconus and other ectatic disorders of the human cornea. The effect of corneal CXL is to increase the stiffness of the stroma to prevent the progression of the cornea distortion. Several clinical and experimental studies have shown that the stiffening effects predominantly localize on the anterior portion of the stroma and that the in-depth stiffening distribution is highly dependent on the duration of treatment. Yet, how th… Show more

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