A Predictive Model of the Effects of Depression, Anxiety, Stress, 6-Minute-Walk Distance, and Social Support on Health-Related Quality of Life in an Adult Pulmonary Hypertension Population

Tartavoulle, Todd

doi:10.1097/nur.0000000000000099

Cited by 14 publications

(17 citation statements)

References 14 publications

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“…One might speculate that as men reported a larger social support and network and more often living with a partner, this might have helped them to access and comprehend information. In addition, women having less social backing is in concordance with a previous study where a diagnosis of PAH, which is a predominantly female disease, caused a reduction in social support [23]. Thus, it is vital that healthcare professionals make an effort to support patients, in the discussions on positive coping strategies include the importance of involving the next of kin in what it means to live with a lifelong disease.…”

Section: Discussionsupporting

confidence: 84%

Information, social support and coping in patients with pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension—A nationwide population-based study

Ivarsson

Rådegran

Hesselstrand

et al. 2017

Patient Education and Counseling

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Section: Discussionsupporting

confidence: 84%

Information, social support and coping in patients with pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension—A nationwide population-based study

Ivarsson

Rådegran

Hesselstrand

et al. 2017

Patient Education and Counseling

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“…This is in line with other studies that found an association of low NYHA class with better HRQoL and high NYHA class with worse HRQoL in PH patients [35,36]. In line with others, we could confirm a correlation between HRQoL and exercise performance [4,5,6]. …”

Section: Discussionsupporting

confidence: 82%

“…Cognitive deficits were found in more than half of PAH patients and mainly presented as worsening in verbal learning, delayed verbal memory, reduced executive function and failed fine motor scores. A decline in cognitive function might also be associated with reduced health-related quality of life (HRQoL), which itself is known to be associated with disease progression [3,4,5,6]. …”

Section: Introductionmentioning

confidence: 99%

Disease-Targeted Treatment Improves Cognitive Function in Patients with Precapillary Pulmonary Hypertension

Somaini¹,

Stamm²,

Müller-Mottet³

et al. 2015

Respiration

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Background: Patients with pulmonary hypertension (PH) may suffer from cognitive deficits that potentially relate to reduced oxygen delivery and cerebral tissue oxygenation (CTO). Objective: To evaluate the hypothesis that cognitive function improves with therapy, along with improved CTO. Methods: Twenty incident patients with arterial or chronic thromboembolic PH had CTO monitoring by near-infrared spectroscopy during diagnostic right heart catheterization. Cognitive tests [Trail Making Tests (TMTs), Victoria Stroop tests and the Five-Point Test (5PT)], the 6-min walk distance (6MWD) test, New York Heart Association (NYHA) class and health-related quality of life (HRQoL) were assessed and repeated after 3 months of disease-targeted medication. Results: At baseline, 45% of PH patients had cognitive deficits. At 3 months, the patients had improved on the TMT A and the Stroop 2 test [37 s (27; 55) versus 30 s (24; 42), p < 0.05, and 18 s (16; 22) versus 16 s (15; 20), p < 0.01], whereas CTO remained unchanged. Arterial oxygen saturation, NYHA class, 6MWD and HRQoL had also improved. Baseline CTO was the strongest predictor of cognitive function, even in multivariate analysis including age, 6MWD and HRQoL. Improvements in cognitive function were not associated with changes in CTO. Conclusions: In patients with PH, 3 months of disease-targeted medication resulted in better cognitive function. Although CTO was the strongest predictor of cognitive function at baseline, it did not change during target therapy. The results of this pilot study should be confirmed in an adequately powered controlled trial.

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“…The differential impact of drug therapy, health provider support or patients' own coping strategies cannot be defined according to our study, but would be helpful and important to know for health care providers in order to offer the best strategy to support their patients in achieving not only better functional capacity and exercise performance, but also less mood disorders. Our data support a transient improvement of mental disorders by modern PH treatment along with improvements in functional class and HRQoL [29,30,31,32]. In an ethnographic study by Kingman et al published in 2014 [33], PH patients were divided into solution seekers and disease-dominated.…”

Section: Discussionmentioning

confidence: 96%

Prevalence of Anxiety and Depression in Pulmonary Hypertension and Changes during Therapy

et al. 2016

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Background: Pulmonary hypertension (PH) leads to reduced health-related quality of life (HRQoL). Objective: To investigate the prevalence and course of anxiety and depression and their association with HRQoL, disease severity and survival in PH. Methods: 131 PH patients (91 pulmonary arterial, 30 chronic thromboembolic, 10 due to lung disease; 84 female, 47 male) had repeated assessments with the Hospital Anxiety and Depression Scale (HADS), HRQoL, six-minute walk distance and WHO functional class during a mean course of 16 ± 12 months. Results: Among the 49 incident and 82 prevalent PH patients, the HADS score was positive in 53%/21% (depression), 51%/24% (anxiety) and 63%/26% (total score) (all p < 0.05). The HADS score was improved at the second assessment in incident patients. The HADS score correlated with HRQoL at all consecutive assessments and with functional class until the third assessment, but not with baseline hemodynamics, age or gender. Conclusion: Mood disorders remain underdiagnosed in PH. The higher prevalence of anxiety/depression in incident versus prevalent patients and the improvement over time may indicate an amelioration of mood disorders after PH diagnosis and treatment.

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A Predictive Model of the Effects of Depression, Anxiety, Stress, 6-Minute-Walk Distance, and Social Support on Health-Related Quality of Life in an Adult Pulmonary Hypertension Population

Cited by 14 publications

References 14 publications

Information, social support and coping in patients with pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension—A nationwide population-based study

Information, social support and coping in patients with pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension—A nationwide population-based study

Disease-Targeted Treatment Improves Cognitive Function in Patients with Precapillary Pulmonary Hypertension

Prevalence of Anxiety and Depression in Pulmonary Hypertension and Changes during Therapy

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