A Predictive Approach of the Influence of the Operating Parameters on the Size of Polymer Particles Synthesized in a Simplified Microfluidic System

Serra, Christophe A.; Berton, Nicolas; Bouquey, Michel; Prat, Laurent E.; Hadziioannou, Georges

doi:10.1021/la063289s

Cited by 92 publications

(76 citation statements)

References 44 publications

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“…We note strong differences between the breakup of liquid threads in unbounded conditions (Cramer et al 2004;Ganan-Calvo 1998;Utada et al 2005;Serra et al 2007;Zhang and Stone 1997) and in microconfined geometries (Anna et al 2003;Garstecki et al 2004Garstecki et al , 2005bGarstecki et al , 2005cGarstecki et al , 2006Thorsen et al 2001). For example, Cramer et al (2004) reported that in the case of break-up in co-flow of liquids in unbounded conditions a decrease in the value of interfacial tension between the immiscible phases results in the reduction of droplet size.…”

Section: Introductionmentioning

confidence: 88%

“…We verified that the Weber number, We = qm 2 l/c, was approximately 0.0015*0.40; since We \ 1 the interfacial tension forces dominate inertia and the capillary number forms the correct dimensionless group for the description of the behavior of our system. We note that the capillary numbers of the droplet and continuous phase, Ca i and Ca o , respectively, are related as (Serra et al 2007). For this experiment, the rate-of-flow-controlled breakup model predicts no variation in the volume of the droplets (since the value of Q o /Q i stays constant), while the shearing mechanism predicts the volume to decrease with the capillary number (with the third power of Ca for breakup in unbounded fluids).…”

Section: Volume Of the Dropletsmentioning

confidence: 99%

“…Since the generation of droplets with a predictable and reproducible size and size distribution determines their potential applications (including the synthesis of polymer colloids), several research groups have explored various aspects of the process of emulsification (Seo et al 2005a;Xu et al 2005;Zhang et al 2006;Cygan et al 2005;El-Ali et al 2005;Garstecki et al 2005a;Hudson et al 2005;Jensen and Lee 2004;Khan et al 2004;Song et al 2003;Zheng and Ismagilov 2005;Zheng et al 2003) . It has been observed that the size of droplets is controlled by the design of the microfluidic device (Sugiura et al 2002a, b;Tan et al 2006), the properties of liquids, and the rates of flow of two immiscible phases (Cramer et al 2004;GananCalvo 1998;Ganan-Calvo and Gordillo 2001;Garstecki et al 2004Garstecki et al , 2005aGarstecki et al , 2005bGarstecki et al , 2006Thorsen et al 2001;Serra et al 2007;Tice et al 2003;Ward et al 2005).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Emulsification in a microfluidic flow-focusing device: effect of the viscosities of the liquids

Nie

Seo

et al. 2008

Microfluid Nanofluid

325

236

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We report the results of a comparative study of microfluidic emulsification of liquids with different viscosities. Depending on the properties of the fluids and their rates of flow, emulsification occurred in the dripping and jetting regimes. We studied the characteristic features and typical dependence of the size and of the size distribution of droplets in each regime. For each liquid, we identified a range of hydrodynamic conditions promoting generation of highly monodisperse droplets. Viscosity played an important role in emulsification: highly viscous liquids were emulsified into larger droplets with lower polydispersity. Although it was not possible to provide a unified scaling for the volumes of the droplets, our results suggest that the break-up dynamics of the lower viscosity fluids resembles the rate-of-flow-controlled break-up, as reported earlier for the formation of bubbles in flow-focusing geometries [Garstecki P, Stone HA, Whitesides GM (2005) Phys Rev Lett 94:164501]. The results of this study can be helpful for a rationalized selection of liquids for the controlled formation of droplets with a predetermined size and with a narrow distribution of sizes.

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Section: Introductionmentioning

confidence: 88%

Section: Volume Of the Dropletsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Emulsification in a microfluidic flow-focusing device: effect of the viscosities of the liquids

Nie

Seo

et al. 2008

Microfluid Nanofluid

325

236

View full text Add to dashboard Cite

show abstract

“…17 Once droplets are produced they can be solidified using appropriate reactions. UV photopolymerisation is an effective and convenient way to crosslink droplets produced by microfluidic methods using functionalised polymers, [18][19][20] however, limited studies have been performed with hydrogels 21 and fewer again with synthetic or biosynthetic hydrogels. 22 The production of microspheres by coupling microfluidic droplet formation with UV photopolymerisation is a promising technique for use with biosynthetic hydrogel macromers and particularly for use in cell encapsulation.…”

Section: Introductionmentioning

confidence: 99%

Poly(vinyl alcohol)-heparin biosynthetic microspheres produced by microfluidics and ultraviolet photopolymerisation

et al. 2013

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Biosynthetic microspheres have the potential to address some of the limitations in cell microencapsulation; however, the generation of biosynthetic hydrogel microspheres has not been investigated or applied to cell encapsulation. Droplet microfluidics has the potential to produce more uniform microspheres under conditions compatible with cell encapsulation. Therefore, the aim of this study was to understand the effect of process parameters on biosynthetic microsphere formation, size, and morphology with a co-flow microfluidic method. Poly(vinyl alcohol) (PVA), a synthetic hydrogel and heparin, a glycosaminoglycan were chosen as the hydrogels for this study. A capillary-based microfluidic droplet generation device was used, and by varying the flow rates of both the polymer and oil phases, the viscosity of the continuous oil phase, and the interfacial surface tension, monodisperse spheres were produced from $200 to 800 lm. The size and morphology were unaffected by the addition of heparin. The modulus of spheres was 397 and 335 kPa for PVA and PVA/heparin, respectively, and this was not different from the bulk gel modulus (312 and 365 for PVA and PVA/heparin, respectively). Mammalian cells encapsulated in the spheres had over 90% viability after 24 h in both PVA and PVA/heparin microspheres. After 28 days, viability was still over 90% for PVA-heparin spheres and was significantly higher than in PVA only spheres. The use of biosynthetic hydrogels with microfluidic and UV polymerisation methods offers an improved approach to long-term cell encapsulation. V C 2013 AIP Publishing LLC. [http://dx

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“…The technique can be applied for the two-step synthesis of Au/Ag core/shell nanoparticles with high homogeneity [19] and for the hydrothermal continuous-flow synthesis of ZnO micro-and nanoparticles [20]. On the other hand, the application of microfluidic devices with coaxial arrangements of fluid channels and flow-focusing allows the preparation of different kinds of polymer particles with very high reproducibility [21,22].…”

Section: Introductionmentioning

confidence: 99%

Continuous-Microflow Synthesis and Morphological Characterization of Multiscale Composite Materials Based on Polymer Microparticles and Inorganic Nanoparticles

Kraus¹,

Li²,

Knauer³

et al. 2014

J Flow Chem

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This paper presents a new route to the synthesis of uniform and size-controlled inorganic/organic composite microparticles by means of microreaction technology. Au-nanoparticles in the range of 3 to 14 nm are synthesized by reduction of tetrachloroauric acid, while ZnO-nanoparticles (200-2000 nm) are synthesized in a continuous-flow twostep process using microtube arrangements for microsegmented flow. Both inorganic nanoparticles have a wellcontrolled size and narrow size distribution. Upon surface modification, the nanoparticles are then mixed on one hand with an acrylate-based monomer and, on the other hand, with an aqueous solution of acrylamide. Both solutions were then emulsified into uniform core-shell droplets by means of a capillary-based microfluidic device. Droplet's shell was hardened through UV-induced polymerization, whereas the core led to a hydrogel upon thermal-induced polymerization. Core-shell polymer microparticles (200-300 µm) with inorganic nanoparticles selectively incorporated into the core and the shell are thus obtained as proven by extensive morphological characterizations using electronic and optical microscopies.

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A Predictive Approach of the Influence of the Operating Parameters on the Size of Polymer Particles Synthesized in a Simplified Microfluidic System

Cited by 92 publications

References 44 publications

Emulsification in a microfluidic flow-focusing device: effect of the viscosities of the liquids

Emulsification in a microfluidic flow-focusing device: effect of the viscosities of the liquids

Poly(vinyl alcohol)-heparin biosynthetic microspheres produced by microfluidics and ultraviolet photopolymerisation

Continuous-Microflow Synthesis and Morphological Characterization of Multiscale Composite Materials Based on Polymer Microparticles and Inorganic Nanoparticles

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