A prediction survival model for out-of-hospital cardiopulmonary resuscitations

Andjelic, Sladjana

doi:10.1016/j.jcrc.2010.06.001

Cited by 18 publications

(12 citation statements)

References 21 publications

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“…On the other hand, the role of β-APP-related amyloidogenic peptides in mediating synaptic disruption has been examined by studying their direct effects on synaptic mechanisms, especially long-term potentiation (LTP). LTP is a neurophysiological model of activity dependent changes in synaptic strength that is believed to underlie information storage ( Kim et al, 2001 ) and memory as one of the basic cognitive functions ( Sladjana, 2011 ). Extensive research about the potential therapeutic effects of antioxidants in the treatment of AD has produced promising results.…”

Section: Introductionmentioning

confidence: 99%

Effect of Gallic Acid on Dementia Type of Alzheimer Disease in Rats: Electrophysiological and Histological Studies

Hajipour

Sarkaki

Farbood

et al. 2016

BCN

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Introduction:To study the effect of gallic acid (GA) on hippocampal long-term potentiation (LTP) and histological changes in animal model of Alzheimer disease (AD) induced by beta-amyloid (Aβ).Methods:Sixty-four adult male Wistar rats (300±20 g) were divided into 8 groups: 1) Control (Cont); 2) AD; 3) Sham; 4–7) AD+GA (50, 100, and 200 mg/kg for 10 days, orally) or vehicle, 8) Cont+GA100, Aβ (1μg/μL in each site) was infused into hippocampus bilaterally. Changes of amplitude and slope of LTP induced in hippocampal dentate gyrus (DG) were evaluated by high frequency stimulation (HFS) of perforant path (PP).Results:Data showed that LTP amplitude and area under curve significantly impaired in AD rats (P<0.001), while significantly improved in AD rats treated with GA (P<0.05, P<0.01).Conclusion:Current findings suggest that GA reduces neural damage and brain amyloid neuropathology and improves cognitive function via free radicals scavenging and inhibiting oligomerization of Aβ but with no effect on healthy rats.

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Section: Introductionmentioning

confidence: 99%

Effect of Gallic Acid on Dementia Type of Alzheimer Disease in Rats: Electrophysiological and Histological Studies

Hajipour

Sarkaki

Farbood

et al. 2016

BCN

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“…Patient-and arrest-specific risk factors for poor outcome following cardiac arrest have been described [12][13][14][15][16][17], but few studies have reported center outcomes adjusted for risk using patient-level data [7,8] or identified in-hospital factors that may explain variation between centers. We sought to develop a risk-adjustment model to evaluate between-center effects of functional outcome at hospital discharge in patients with OHCA who received TTM as an initial step to identify potential in-hospital treatment variation that might explain such differences.…”

Section: Introductionmentioning

confidence: 99%

Variability in functional outcome and treatment practices by treatment center after out-of-hospital cardiac arrest: analysis of International Cardiac Arrest Registry

et al. 2019

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Functional outcomes vary between centers after out-of-hospital cardiac arrest (OHCA) and are partially explained by pre-existing health status and arrest characteristics, while the effects of in-hospital treatments on functional outcome are less understood. We examined variation in functional outcomes by center after adjusting for patient-and arrest-specific characteristics and evaluated how in-hospital management differs between high-and low-performing centers. Methods: Analysis of observational registry data within the International Cardiac Arrest Registry was used to perform a hierarchical model of center-specific risk standardized rates for good outcome, adjusted for demographics, preexisting functional status, and arrest-related factors with treatment center as a random effect variable. We described the variability in treatments and diagnostic tests that may influence outcome at centers with adjusted rates significantly above and below registry average. Results: A total of 3855 patients were admitted to an ICU following cardiac arrest with return of spontaneous circulation. The overall prevalence of good outcome was 11-63% among centers. After adjustment, center-specific risk standardized rates for good functional outcome ranged from 0.47 (0.37-0.58) to 0.20 (0.12-0.26). High-performing centers had faster time to goal temperature, were more likely to have goal temperature of 33 °C, more likely to perform unconscious cardiac catheterization and percutaneous coronary intervention, and had differing prognostication practices than low-performing centers. Conclusions: Center-specific differences in outcomes after OHCA after adjusting for patient-specific factors exist. This variation could partially be explained by in-hospital management differences. Future research should address the contribution of these factors to the differences in outcomes after resuscitation.

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“…Given the direct relationship between the quality of CPR and survival, [4,27,28] CPR training requires appropriate assessment of the skills acquired. Our study shows that classical evaluation by human observation does not have adequate agreement with the more accurate assessment by a dedicated mechanical system.…”

Section: Discussionmentioning

confidence: 99%