A prediction model for left ventricular mass in patients at high cardiovascular risk

Meijs, Matthijs F.L.; Vergouwe, Yvonne; Vonken, Evert-Jan; Velthuis, Birgitta K.; Verton, David J.; Graaf, Yolanda van der; Visseren, Frank L.J.; Mali, Willem P.Th.M.; Doevendans, Pieter A.; Bots, Michiel L.

doi:10.1097/hjr.0b013e328332d4bc

Cited by 10 publications

(12 citation statements)

References 43 publications

(62 reference statements)

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“…Furthermore, we confirmed, in a larger sample size, our previous findings of greater LVM in adolescents with T1D with an even shorter disease duration (6). Increased LVM and left ventricular hypertrophy are strong independent predictors of future CVD (25, 26). The relatively favorable cardiac values observed in girls compared to boys in the control group were tempered in T1D.…”

Section: Discussionmentioning

confidence: 99%

Youth with type 1 diabetes have worse strain and less pronounced sex differences in early echocardiographic markers of diabetic cardiomyopathy compared to their normoglycemic peers: A RESistance to InSulin in Type 1 ANd Type 2 diabetes (RESISTANT) Study

Bjornstad

Truong

Pyle

et al. 2016

Journal of Diabetes and its Complications

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Objective Diabetic cardiomyopathy is a major cause of morbidity, but limited data are available on early cardiac abnormalities in type 1 diabetes (T1D). We investigated differences in myocardial strain in adolescents with and without T1D. We hypothesized that adolescents with T1D would have worse strain than their normoglycemic peers, which boys would have worse strain than girls, and that strain would correlate with glycemic control and adipokines. Methods We performed fasting laboratory measures and echocardiograms with speckle tracking to evaluate traditional echocardiographic measures in addition to longitudinal (LS) and circumferential (CS) strain, and in adolescents (15±2 years) with (19 boys; 22 girls) and without (16 boys; 32 girls) type 1 diabetes. Results Compared to controls, adolescents with type 1 diabetes had significantly lower CS (−20.9 vs. −22.7%, p=0.02), but not LS (p=0.83). Boys with T1D had significantly lower LS than girls with T1D (−17.5 vs. −19.7%, p=0.047), adjusted for Tanner stage. The significant sex differences observed in indexed left ventricular mass, left end-diastolic volume, diastolic septal and posterior wall thickness in our controls were lacking in adolescents with T1D. Conclusions Our observations suggest that youth with T1D have worse myocardial strain than normoglycemic peers. In addition, the relatively favorable cardiac profile observed in girls vs. boys in the control group, was attenuated in T1D. These early cardiovascular changes in youth with T1D are concerning and warrant longitudinal and mechanistic studies.

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Section: Discussionmentioning

confidence: 99%

Youth with type 1 diabetes have worse strain and less pronounced sex differences in early echocardiographic markers of diabetic cardiomyopathy compared to their normoglycemic peers: A RESistance to InSulin in Type 1 ANd Type 2 diabetes (RESISTANT) Study

Bjornstad

Truong

Pyle

et al. 2016

Journal of Diabetes and its Complications

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“…An accurate prediction model identifying patients at high risk of LVH in the early stages might be useful in the prevention of cardiovascular events. Until now, only a small number of prediction models for left ventricular mass have been reported 6‐9 . However, most of these models were designed using the Caucasian populations.…”

Section: Introductionmentioning

confidence: 99%

Development of a nomogram for screening the risk of left ventricular hypertrophy in Chinese hypertensive patients

Wang

Gong

et al. 2021

J of Clinical Hypertension

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Hypertension is the leading risk factor for cardiovascular diseases and premature mortality worldwide. 1 Recent global trends showed that the prevalence of hypertension has decreased in high-income countries, but increased in low-and middle-income countries. 2 The Status of Hypertension in China published in 2018 revealed that the prevalence of hypertension in Chinese adults is 23.2% and is gradually rising. 3 Left ventricular hypertrophy (LVH) is a common complication of hypertension and is a key mediator between the risk factors and the cardiovascular events. 4 It has been reported that multiple factors, such as blood pressure level, age, obesity, gender, the severity of hypertension, and dietary salt intake, are involved in the development of LVH. 5

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“…However, this only increases the value of the association of albuminuria with LVM found, as presence of albuminuria is associated with a greater LVM several years later regardless of the course of renal function and albuminuria in the years between. Systolic blood pressure was remeasured at the time of the MRI with no significant changes found compared to the baseline (data not shown) . Also the time between inclusion in SMART and MRI did not have a significant relation to LV mass.…”

Section: Discussionmentioning

confidence: 94%

Presence of albuminuria predicts left ventricular mass in patients with chronic systemic arterial hypertension

Beus

Meijs

Bots³

et al. 2015

Eur J Clin Investigation

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A prediction model for left ventricular mass in patients at high cardiovascular risk

Cited by 10 publications

References 43 publications

Youth with type 1 diabetes have worse strain and less pronounced sex differences in early echocardiographic markers of diabetic cardiomyopathy compared to their normoglycemic peers: A RESistance to InSulin in Type 1 ANd Type 2 diabetes (RESISTANT) Study

Youth with type 1 diabetes have worse strain and less pronounced sex differences in early echocardiographic markers of diabetic cardiomyopathy compared to their normoglycemic peers: A RESistance to InSulin in Type 1 ANd Type 2 diabetes (RESISTANT) Study

Development of a nomogram for screening the risk of left ventricular hypertrophy in Chinese hypertensive patients

Presence of albuminuria predicts left ventricular mass in patients with chronic systemic arterial hypertension

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