A Prediction Formula for Double Product in Pregnancy

Abstract

IntrOductIOnPregnancy is the most important and essential physiological adaptation in the body. Overwhelming changes occur virtually in all the systems of the body, modifications in the cardiovascular system are constituent of the same. Systolic and diastolic blood pressures are found to decrease during second trimester. Cardiac output, heart rate and stroke volume tend to increase during pregnancy, thereby reducing the myocardial oxygen demand [1].Myocardial oxygen consumption is relatively high compared to other organs. High oxygen consumption by the myocardium is required for the contraction and relaxation of cardiac muscle. Hence, the myocardial metabolism and function are closely related [2]. These adaptations during pregnancy are usually well tolerated by healthy women. However, there is a threat to those who are with ischemic heart diseases.Acute Myocardial Infarction (AMI) is rare in women of child bearing age. But increase in risk of AMI has been shown from 3-4 fold [3][4][5][6]. Recent advances in reproduction and child bearing by older women are expected to increase the occurrence of AMI [7].

A study on rate pressure product in south Indian pregnant women with anaemia

“…17 A study conducted by Teli et al, showed that there was a statistically significant increase in double product in pregnancy in all trimesters and the rise was more noticed in the third trimester. 18 These findings shows that there is an enhanced stroke volume and heart rate during pregnancy which may lead to increased myocardial oxygen demand. Thus, an increase in RPP is an important marker and a risk predictor of cardiovascular disease.…”