A Prediction Error-driven Retrieval Procedure for Destabilizing and Rewriting Maladaptive Reward Memories in Hazardous Drinkers

Das, Ravi; Gale, Grace; Hennessy, Vanessa; Kamboj, Sunjeev K.

doi:10.3791/56097

Cited by 18 publications

(16 citation statements)

References 54 publications

(80 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings were also in line with the evidence from a study, in which re-association of the alcohol cues with aversion upon alcohol memory retrieval yielded reduction in craving for alcohol in hazardous drinkers (Das et al, 2015;Das et al, 2018).…”

Section: Introductionsupporting

confidence: 89%

“…This finding has a critical translational value, as unlike the CPP paradigm, in which exposure to a drug of abuse is short and involuntary (Tzschentke, 2007), operant self-administration procedures are used to model a variety of aspects in addiction (Shaham et al, 2003;Crombag et al, 2008;Everitt et al, 2008;Marchant et al, 2013a;Venniro et al, 2016), including alcohol relapse after prolonged voluntary consumption (Koob, 2000;Burattini et al, 2006;Epstein et al, 2006;Goltseker et al, 2019). Moreover, the retrieval-counterconditioning paradigm is feasible in humans, as it was recently shown that re-association of the alcohol cues with aversion upon alcohol memory reactivation, yielded reduction in alcohol craving in hazardous drinkers (Das et al, 2015;Das et al, 2018).…”

Section: Behavioral Interference With Alcohol Memory Reconsolidation mentioning

confidence: 99%

“…It is established that memory reconsolidation can be disrupted by pharmacological manipulations (Nader et al, 2000;Dunbar and Taylor, 2017b). However, the toxicity or side effects of most relevant pharmacological amnesic agents (mainly protein synthesis inhibitors) (Nader et al, 2000;Dunbar and Taylor, 2017b), facilitated the development of behavioral manipulations to interfere with memory reconsolidation Xue et al, 2012;Millan et al, 2013;Sartor and Aston-Jones, 2014;Das et al, 2015;Luo et al, 2015;Cofresi et al, 2017;Goltseker et al, 2017;Das et al, 2018;Gera et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Disruption of relapse to alcohol seeking by aversive counterconditioning following memory retrieval

Goltseker

Handrus

Barak

2019

Preprint

View full text Add to dashboard Cite

Relapse to alcohol abuse is often caused by exposure to potent alcohol-associated cues. Therefore, disruption of the cue-alcohol memory can prevent relapse. It is believed that memories destabilize and become prone for updating upon their reactivation through retrieval, and then re-stabilize within 6 h during a "reconsolidation" process. We recently showed that relapse to cocaine seeking could be prevented by counterconditioning the cocaine-cues with aversive outcomes following cocaine-memory retrieval, in a place conditioning paradigm. However, to better model addictionrelated behaviors, self-administration models are necessary. Here, we demonstrate that relapse to alcohol seeking can be prevented by aversive counterconditioning conducted during alcoholmemory reconsolidation, in conditioned place preference (CPP) and operant self-administration paradigms, in mice and rats, respectively. We found that the reinstatement of alcohol-CPP was abolished only when aversive counterconditioning with water-flooding was given shortly after alcohol-memory retrieval. Furthermore, rats trained to lever-press for alcohol showed decreased context-induced renewal of alcohol-seeking responding when the lever-pressing was counterconditioned with foot-shocks, shortly, but not 6 h, after memory retrieval. These results 0suggest that aversive counterconditioning can prevent relapse to alcohol seeking only when performed during alcohol-memory reconsolidation, presumably by updating, or replacing, the alcohol memory with aversive information. Also, we found that aversive counterconditioning preceded by alcohol-memory retrieval was characterized by upregulation of brain-derived neurotrophic factor (Bdnf) mRNA expression in the medial prefrontal cortex, suggesting that Bdnf plays a role in the memory updating process. Operant self-administration, Conditioned place preference, BDNFAlcohol place conditioning (days 2-9): Training started 24 h after the Baseline test with one session per day over 8 days, with the sliding door closed. On days 3, 5, 7, and 9, mice were administered with alcohol (1.8 g/kg; i.p.) and immediately confined to the paired compartment for 5 min. On the alternate days (days 2, 4, 6, and 8), mice were administered with saline and were confined to the unpaired compartment for the same duration as on the alcohol-conditioning day.Paired compartments were counterbalanced.Place preference test 1 (day 10): Place preference test was identical to the Baseline stage, and served to index alcohol-CPP (Cunningham et al., 2003). Preference was defined as an increase in the percent of time spent in the alcohol-paired compartment during the Place preference test 1 compared to the Baseline test. Mice that did not show CPP (minimum of 5% change) were excluded from the experiment (3 from Experiment 1; 4 from Experiment 2).Memory retrieval and aversive counterconditioning (days 11-14). Prior to this stage, mice were assigned to different experimental conditions, Retrieval and No Retrieval (matched for CPP scores and sex). Training began 2...

show abstract

Section: Introductionsupporting

confidence: 89%

Section: Behavioral Interference With Alcohol Memory Reconsolidation mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Disruption of relapse to alcohol seeking by aversive counterconditioning following memory retrieval

Goltseker

Handrus

Barak

2019

Preprint

View full text Add to dashboard Cite

show abstract

“…For example, a previous human study used two consecutive days of retrieval-extinction training to decrease craving of abstinent heroin users 14 . Das et al demonstrated that maximizing expectancy violation (prediction error) during memory retrieval before counterconditioning led to a substantial reduction in measures of pre-existing alcohol memories of human hazardous drinkers 15,42 .…”

Section: Discussionmentioning

confidence: 99%

Counterconditioning following memory retrieval diminishes reinstatement of appetitive memories in humans

Gera

Barak

Schönberg

2018

Preprint

View full text Add to dashboard Cite

Appetitive memories play a crucial role in learning and behavior but under certain circumstances become maladaptive and play a vital part in addiction and other psychopathologies. In recent years, scientific research demonstrated the ability of memories to be modified following their reactivation through memory retrieval, in a process termed memory reconsolidation. Several non-pharmacological behavioral manipulations yielded mixed results in their capacity to alter maladaptive memories in humans. Here, aiming to translate promising findings observed in rodents to humans, we constructed a novel three-day procedure to test the efficacy of aversive counterconditioning to alter appetitive memories when given following memory retrieval. On Day1 we used appetitive conditioning to form appetitive memories. On Day2, we retrieved these appetitive memories for half of the participants (Retrieval group). Subsequently, all participants underwent counterconditioning.On Day3, we tried to reinstate Day1 appetitive memories. We observed a significant reduction in the reinstatement of the original appetitive memory when counterconditioning was induced following memory retrieval. We provide here a novel human paradigm that models several memory processes, and demonstrate memory attenuation when counterconditioned after its retrieval. This paradigm can be used to study complex appetitive memory dynamics, e.g., memory reconsolidation, and their underlying brain mechanisms.

show abstract

“…The latter involved some form of expectation violation (e.g. generating an expectation that the participant will experience the US, and then violating this expectation; (Das, Gale, Hennessy, & Kamboj, 2018). Table 1, most studies specified the duration of the retrieval procedures used.…”

Section: Retrieval Proceduresmentioning

confidence: 99%

Modulation of naturalistic maladaptive memories using behavioural and pharmacological reconsolidation-interfering strategies: A systematic review and meta-analysis of clinical and 'sub-clinical' studies

Walsh

Das

Saladin

et al. 2018

Preprint

View full text Add to dashboard Cite

Consolidated memories can undergo enduring modification through retrieval-dependent treatments that modulate reconsolidation. This has been suggested to represent a potentially transformative clinical strategy for weakening or overwriting the maladaptive memories that underlie substance use and anxiety/trauma-related disorders. However, the ability to modulate naturalistic maladaptive memories may be limited by 'boundary conditions' imposed on reconsolidation by the nature of these memories. As such, the true potential of 'reconsolidation therapy' is currently unknown. Here, we report a meta-analyses of behavioural and pharmacological studies examining retrieval-dependent modulation of reward and threat memories in (sub)clinical substance use and anxiety/trauma respectively.Of 4936 publications assessed for eligibility, 7 studies of substance use, and 9 of anxiety (phobia) and trauma-related symptoms were included in the meta-analyses. Overall, the findings were in the predicted direction, with the majority of effect sizes favouring the 'Retrieval + Treatment' condition. However, the magnitude of effects depended upon the nature of the treatment type, with pharmacological interventions (relative to behavioural strategies) showing a clearer beneficial effect in studies of phobia/trauma and post-retrieval behavioural strategies, a (significantly) larger effect in substance use studies. However, high levels of heterogeneity and small sample sizes limit the strength of conclusions that can be drawn at this stage of inquiry. We hope this review will provide an impetus to address these issues in future research.

show abstract

A Prediction Error-driven Retrieval Procedure for Destabilizing and Rewriting Maladaptive Reward Memories in Hazardous Drinkers

Cited by 18 publications

References 54 publications

Disruption of relapse to alcohol seeking by aversive counterconditioning following memory retrieval

Disruption of relapse to alcohol seeking by aversive counterconditioning following memory retrieval

Counterconditioning following memory retrieval diminishes reinstatement of appetitive memories in humans

Modulation of naturalistic maladaptive memories using behavioural and pharmacological reconsolidation-interfering strategies: A systematic review and meta-analysis of clinical and 'sub-clinical' studies

Contact Info

Product

Resources

About