A preclinical model of binge eating elicited by yo-yo dieting and stressful exposure to food: effect of sibutramine, fluoxetine, topiramate, and midazolam

Cifani, Carlo; Polidori, Carlo; Melotto, Sergio; Ciccocioppo, Roberto; Massi, Maurizio

doi:10.1007/s00213-008-1442-y

Cited by 87 publications

(121 citation statements)

References 50 publications

(72 reference statements)

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“…In the model developed by Cifani et al (2009), BE is elicited by yo-yo dieting and stressful exposure to HPF. In this model, female rats are exposed to repeated cycles of restriction and a stressful procedure characterized by exposure of animals to HPF without the possibility of access to it.…”

Section: Discussionmentioning

confidence: 99%

“…This generated a mildly stressful condition that causes a significant increase in serum corticosterone levels (Cifani et al, 2009). After 15 min, the cup was placed inside the cage of rats of the stress groups, so that HPF became accessible to them.…”

Section: Experiments 4: Binge Eatingmentioning

confidence: 99%

“…Topiramate, used as reference compound for this experimental paradigm (Cifani et al, 2009), was tested in the same rats, 10 days after the end of SB-649868 experiment. Of these 108 animals, 72 were divided into the same four groups (18 animals for each group) described before.…”

Section: Experiments 4a: Effect Of Sb-649868 and Topiramatementioning

confidence: 99%

“…Therefore, this study was aimed at investigating the effect of the dual OX 1 /OX 2 R antagonist SB-649868 (N-[((2S)-1-{[5-(4-fluorophenyl)-2-methyl-1,3-thiazol-4-yl]carbonyl}-2-piperidinyl)methyl]-1-benzofuran-4-carboxamide) (Di Fabio et al, 2011), the selective OX 1 R antagonist GSK1059865 (5-bromo-N-[(2S,5S)-1-(3-fluoro-2-methoxybenzoyl)-5-methylpiperidin-2-yl]methyl-pyridin-2-amine) (Gozzi et al, 2011), and the selective OX 2 R antagonist JNJ-10397049 (N-(2,4-dibromophenyl) (McAtee et al, 2004;Dugovic et al, 2009) in the BE model described by Cifani et al (2009), in which BE episodes for HPF is evoked in female rats by cycles of food restriction/re-feeding and acute stress. The three antagonists were first evaluated in vitro in rat recombinant OX 1 R and OX 2 R to determine their potency and to confirm their selectivity for the two receptor subtypes.…”

Section: Introductionmentioning

confidence: 99%

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Role of Orexin-1 Receptor Mechanisms on Compulsive Food Consumption in a Model of Binge Eating in Female Rats

Piccoli

Bonaventura

Cifani

et al. 2012

Neuropsychopharmacol

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141

102

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Orexins (OX) and their receptors (OXR) modulate feeding, arousal, stress, and drug abuse. Neural systems that motivate and reinforce drug abuse may also underlie compulsive food seeking and intake. Therefore, the effects of GSK1059865, a dual OX 1 /OX 2 R antagonist were evaluated in a binge eating (BE) model in female rats. BE of highly palatable food (HPF) was evoked by three cycles of food restriction followed by stress, elicited by exposing rats to HPF, but preventing them from having access to it for 15 min. Pharmacokinetic assessments of all compounds were obtained under the same experimental conditions used for the behavioral experiments. Topiramate was used as the reference compound as it selectively blocks BE in rats and humans. Dose-related thresholds for sleep-inducing effects of the OXR antagonists were measured using polysomnography in parallel experiments. SB-649868 and GSK1059865, but not JNJ-10397049, selectively reduced BE for HPF without affecting standard food pellet intake, at doses that did not induce sleep. These results indicate, for the first time, a major role of OX 1 R mechanisms in BE, suggesting that selective antagonism at OX 1 R could represent a novel pharmacological treatment for BE and possibly other eating disorders with a compulsive component.

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Section: Discussionmentioning

confidence: 99%

Section: Experiments 4: Binge Eatingmentioning

confidence: 99%

Section: Experiments 4a: Effect Of Sb-649868 and Topiramatementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Role of Orexin-1 Receptor Mechanisms on Compulsive Food Consumption in a Model of Binge Eating in Female Rats

Piccoli

Bonaventura

Cifani

et al. 2012

Neuropsychopharmacol

Self Cite

141

102

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“…Indeed, there is an important interaction between food binging and stress. Binge eating can be triggered by foot shock stress [112,113] or the frustrating presence of an unreachable (but easily visible) palatable treat [114]. Food restriction itself is also stressful and this may promote binge eating [115].…”

Section: Models For Aspects Of Food Addiction-like Behavior and Neuromentioning

confidence: 99%

Towards an Animal Model of Food Addiction

Jong¹,

Vanderschuren²,

Adan³

2012

Obes Facts

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The dramatically increasing prevalence of obesity, associated with potentially life-threatening health problems, including cardiovascular diseases and type II diabetes, poses an enormous public health problem. It has been proposed that the obesity epidemic can be explained by the concept of ‘food addiction’. In this review we focus on possible similarities between binge eating disorder (BED), which is highly prevalent in the obese population, and drug addiction. Indeed, both behavioral and neural similarities between addiction and BED have been demonstrated. Behavioral similarities are reflected in the overlap in DSM-IV criteria for drug addiction with the (suggested) criteria for BED and by food addiction-like behavior in animals after prolonged intermittent access to palatable food. Neural similarities include the overlap in brain regions involved in food and drug craving. Decreased dopamine D2 receptor availability in the striatum has been found in animal models of binge eating, after cocaine self-administration in animals as well as in drug addiction and obesity in humans. To further explore the neurobiological basis of food addiction, it is essential to have an animal model to test the addictive potential of palatable food. A recently developed animal model for drug addiction involves three behavioral characteristics that are based on the DSM-IV criteria: i) extremely high motivation to obtain the drug, ii) difficulty in limiting drug seeking even in periods of explicit non-availability, iii) continuation of drug-seeking despite negative consequences. Indeed, it has been shown that a subgroup of rats, after prolonged cocaine self-administration, scores positive on these three criteria. If food possesses addictive properties, then food-addicted rats should also meet these criteria while searching for and consuming food. In this review we discuss evidence from literature regarding food addiction-like behavior. We also suggest future experiments that could further contribute to our understanding of behavioral and neural commonalities and differences between obesity and drug addiction.

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Estrogenic suppression of binge‐like eating elicited by cyclic food restriction and frustrative‐nonreward stress in female rats

Bonaventura

Lutz

Romano

et al. 2017

Intl J Eating Disorders

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Objective Because binge eating and emotional eating vary through the menstrual cycle in human females, we investigated cyclic changes in binge-like eating in female rats and their control by estrogens. Method Binge-like eating was elicited by three cycles of 4 days of food restriction and 4 days of free feeding followed by a single frustrative nonreward-stress episode (15 min visual and olfactory exposure to a familiar palatable food) immediately before presentation of the palatable food. Results Intact rats showed binge-like eating during the diestrous and proestrous phases of the ovarian cycle, but not during the estrous (peri-ovulatory) phase. Ovariectomized (OVX) rats not treated with estradiol (E2) displayed binge-like eating, whereas E2-treated OVX rats did not. The procedure did not increase signs of anxiety in an open-field test. OVX rats not treated with E2 that were subjected to food restriction and sacrificed immediately after frustrative nonreward had increased numbers of cells expressing phosphorylated extracellular signal-regulated kinases (ERK) in the central nucleus of the amygdala (CeA), paraventricular nucleus of hypothalamus (PVN), and dorsal and ventral bed nucleus of the stria terminalis (BNST) compared with non-restricted or E2-treated rats. Discussion These data suggest that this female rat model is appropriate for mechanistic studies of some aspects of menstrual-cycle effects on emotional and binge eating in human females, that anxiety is not a sufficient cause of binge-like eating, and that the PVN, CeA and BNST may contribute to information processing underlying binge-like eating.

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A preclinical model of binge eating elicited by yo-yo dieting and stressful exposure to food: effect of sibutramine, fluoxetine, topiramate, and midazolam

Abstract: Pharmacological results suggest that this model, in addition to face validity as an isomorphic model of human binge eating, is endowed with good predictive validity.

Cited by 87 publications

References 50 publications

Role of Orexin-1 Receptor Mechanisms on Compulsive Food Consumption in a Model of Binge Eating in Female Rats

Role of Orexin-1 Receptor Mechanisms on Compulsive Food Consumption in a Model of Binge Eating in Female Rats

Towards an Animal Model of Food Addiction

Estrogenic suppression of binge‐like eating elicited by cyclic food restriction and frustrative‐nonreward stress in female rats

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