A Pre-clinical Study of the Response Threshold of Intact and Transected Nerves to Stimulation by Transcutaneous Intense Focused Ultrasound

Case study of an amputee regaining sensation and muscle function in a residual limb after peripheral nerve stimulation by intense focused ultrasound

“…We used intense focused ultrasound (iFU), delivered under realtime ultrasound image guidance, to stimulate at or near the distal tip of major transected nerves in amputated limbs following a previously described protocol [3,4]. In this way we determined the minimum iFU intensity capable of generating a first discernable sensation through use of a ramp-up paradigm that started at low intensity values and increased until we achieved that aim or reached the maximum intensity value of our device.…”