Localized adverse events, including natural hazards, epidemiological events, and human conflict, underscore the criticality of quantifying and mapping current population. Building on the spatial interpolation technique previously developed for high-resolution population distribution data (LandScan Global and LandScan USA), we have constructed an empirically informed spatial distribution of projected population of the contiguous United States for 2030 and 2050, depicting one of many possible population futures. Whereas most current large-scale, spatially explicit population projections typically rely on a population gravity model to determine areas of future growth, our projection model departs from these by accounting for multiple components that affect population distribution. Modeled variables, which included land cover, slope, distances to larger cities, and a moving average of current population, were locally adaptive and geographically varying. The resulting weighted surface was used to determine which areas had the greatest likelihood for future population change. Population projections of county level numbers were developed using a modified version of the US Census's projection methodology, with the US Census's official projection as the benchmark. Applications of our model include incorporating multiple various scenario-driven events to produce a range of spatially explicit population futures for suitability modeling, service area planning for governmental agencies, consequence assessment, mitigation planning and implementation, and assessment of spatially vulnerable populations.population projections | population distribution | LandScan | high-resolution population I mpacts, adaptations, and vulnerability of population have come into sharp focus in recent years, particularly in light of concerns around global climate change (1). Whether through increased susceptibility to vector-borne disease (2), food scarcity, or extreme weather events, the general consensus is that large populations will be affected by the impacts of climate change (3). Nearly every climate change model predicts some magnitude of sea level rise (4), and whereas a considerable segment of the world's population lives in close proximity to coastal areas (5-8), rising sea levels increase the risk of storm surge, coastal flooding, and other stormrelated hazards (4, 9). The aforementioned scenarios require the examination of tools and data that are necessary to quantify populations at risk to these predicted adverse events, so that appropriate countermeasures can be taken when attempting to allocate potential resources. Spatially explicit gridded population estimates have repeatedly proven their usefulness for planning needs, including those of public health, the environment, disaster mitigation, preparedness and assistance, and service area planning for local, regional, and national governments.Originally pioneered by Semenov-Tian-Shansky (10) and popularized by Wright (11), dasymetric modeling is a key technique for spatial disaggregatio...