A practical synthesis of 5‐(chloromethyl)furo[2,3‐b]pyridine, a key intermediate for the HIV protease inhibitor, L‐754,394

Abstract

A practical synthesis of 5‐(chloromethyl)furo[2,3‐b]pyridine (10), the side chain used to incorporate a key pharmacophore of the HIV protease inhibitor, L‐754,394, is described. The synthesis was accomplished in ten steps and in 15% overall yield from commercially available methyl 2‐furoate.

An Efficient One‐Pot Synthesis of Highly Substituted Pyridone Derivatives and Their Antimicrobial and Antifungal Activity

“…Pyridone scaffold is present in a huge number of natural and synthetic biologically active compounds. 2‐Pyridone derivatives and their analogues have attracted considerable interest recently because of their anti‐microbial, anxiety, antitumor, antiviral, anticancer, antituberculosis, and anti‐inflammatory properties . Well‐known drugs amrinone (a) and milrinone (b) used for the treatment of heart failure contains 2‐pyridone moiety in their structure.…”

Synthesis of new 5-arylazo-1-substitutedpyridone dyes with antibacterial activity

“…Pyridine ring represents the main skeleton of numerous bioactive molecules. Recently 2-pyridone and their derivatives take interest due to their anti-inflammatory, antiviral and antiproliferative activities [1][2][3]. Amrinone (I) [4] and Milrinone (II) [5] have been considered as cardiotonic drugs for the treatment of heart failure.…”

Synthesis and Characterization of Some Novel Coumarin Based 2-Pyridone Heterocycles with their Broad Spectrum Antimicrobial Potency

“…Novobiocin and chlorobiocin have reported as antimicrobials containing a coumarin skeleton [13]. Pyridone and their derivatives play a vital role in some biological processes and have significant chemical and pharmacological importance [14,15,16]. 2-Pyridones motifs found to possess useful pharmacological activities, such as analgesic [17], antimalarial [18], anti-HIV [19], phytotoxic [20], and antitumoral [21] properties.…”