A Practical Synthesis of 2,6-Dicarboxyfluorenone

Abstract

Herein, we report a new and efficient method for the large scale synthesis of 2,6-dicarboxyfluorenone 5 in 95% yield using 0.01 mol% of bis(triphenylphosphine)palladium(II) chloride, (PPh 3 ) 2 PdCl 2 , as a catalyst, starting with the reaction of 2,5-dimethylbromobenzene and 4-bromotoluene to give 2,4,5-trimethylbiphenyl 3, followed by oxidation and then cyclization.

p-Xylene Oxidation to Terephthalic Acid: A Literature Review Oriented toward Process Optimization and Development

“…Oxidation of the methyl group yields a carboxylic or a carbonyl group, which after formation of an aroyl radical is converted to a ketone group via cyclization. This later route has been employed successfully to synthesize 2,6-dicarboxyfluorenone via oxidation of 2,4,5-trimethylbiphenyl to 2,4,5-tricarboxybiphenyl, Figure …”