A practical protocol for large‐scale copper‐mediated radioiodination of organoboronic precursors: Radiosynthesis of [123I]KX‐1 for Auger radiotherapy
Dong Zhou,
Wenhua Chu,
Jinbin Xu
Abstract:Nucleophilic copper‐mediated radioiodination (CMRI) of organoboronic precursors with radioiodides is a promising method of radioiodination. The previously reported CMRI has demonstrated its great potential and scope of labeling for the radiosynthesis of radioiodine‐labeled compounds. However, the reported protocols (using a small amount/volume of radioactivity) are practically not reproducible in large‐scale CMRI, in which the radioactivity was usually provided in a bulk alkaline solution. A large amount of wa… Show more
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